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The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients.
Curr Opin Clin Nutr Metab Care. 2012 Mar; 15(2):151-60.CO

Abstract

PURPOSE OF REVIEW

Hyperglycemia, hypoglycemia and increased glycemic variability are independently associated with increased risk of mortality in critically ill patients. The purpose of this review is to evaluate the evidence from interventional trials of intensive insulin therapy, as well as observational cohort studies, relating premorbid diabetic status and these three domains of glycemic control to mortality.

RECENT FINDINGS

Hyperglycemia has a stronger association with mortality in critically ill patients without diabetes than in those with diabetes. Hypoglycemia is independently associated with increased risk of mortality in both populations. Limited data suggest that increased glycemic variability may have a stronger association with mortality in patients without diabetes than in those with diabetes.

SUMMARY

Premorbid diabetic status impacts the relationship of the three domains of glycemic control to risk of mortality in critically ill patients. The data presented in this review are hypothesis generating; future trials of IIT in the critically ill should stratify management and outcomes by premorbid diabetic status.

Authors+Show Affiliations

Division of Critical Care, Stamford Hospital, Columbia University College of Physicians and Surgeons, Stamford, Connecticut 06902, USA. jkrinsley@stamhealth.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22234163

Citation

Krinsley, James S., et al. "The Impact of Premorbid Diabetic Status On the Relationship Between the Three Domains of Glycemic Control and Mortality in Critically Ill Patients." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 15, no. 2, 2012, pp. 151-60.
Krinsley JS, Meyfroidt G, van den Berghe G, et al. The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients. Curr Opin Clin Nutr Metab Care. 2012;15(2):151-60.
Krinsley, J. S., Meyfroidt, G., van den Berghe, G., Egi, M., & Bellomo, R. (2012). The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients. Current Opinion in Clinical Nutrition and Metabolic Care, 15(2), 151-60. https://doi.org/10.1097/MCO.0b013e32834f0009
Krinsley JS, et al. The Impact of Premorbid Diabetic Status On the Relationship Between the Three Domains of Glycemic Control and Mortality in Critically Ill Patients. Curr Opin Clin Nutr Metab Care. 2012;15(2):151-60. PubMed PMID: 22234163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of premorbid diabetic status on the relationship between the three domains of glycemic control and mortality in critically ill patients. AU - Krinsley,James S, AU - Meyfroidt,Geert, AU - van den Berghe,Greet, AU - Egi,Mori, AU - Bellomo,Rinaldo, PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/5/31/medline SP - 151 EP - 60 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 15 IS - 2 N2 - PURPOSE OF REVIEW: Hyperglycemia, hypoglycemia and increased glycemic variability are independently associated with increased risk of mortality in critically ill patients. The purpose of this review is to evaluate the evidence from interventional trials of intensive insulin therapy, as well as observational cohort studies, relating premorbid diabetic status and these three domains of glycemic control to mortality. RECENT FINDINGS: Hyperglycemia has a stronger association with mortality in critically ill patients without diabetes than in those with diabetes. Hypoglycemia is independently associated with increased risk of mortality in both populations. Limited data suggest that increased glycemic variability may have a stronger association with mortality in patients without diabetes than in those with diabetes. SUMMARY: Premorbid diabetic status impacts the relationship of the three domains of glycemic control to risk of mortality in critically ill patients. The data presented in this review are hypothesis generating; future trials of IIT in the critically ill should stratify management and outcomes by premorbid diabetic status. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/22234163/The_impact_of_premorbid_diabetic_status_on_the_relationship_between_the_three_domains_of_glycemic_control_and_mortality_in_critically_ill_patients_ L2 - https://doi.org/10.1097/MCO.0b013e32834f0009 DB - PRIME DP - Unbound Medicine ER -