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Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies.
Ann Oncol 2012; 23(6):1394-402AO

Abstract

BACKGROUND

Evidence from case-control studies suggest that dietary fiber may be inversely related to breast cancer risk, but it is unclear if this is supported by prospective data. We conducted a systematic review and meta-analysis of the evidence from prospective studies.

METHODS

PubMed was searched for prospective studies of fiber intake and breast cancer risk until 31st August 2011. Random effects models were used to estimate summary relative risks (RRs).

RESULTS

Sixteen prospective studies were included. The summary RR for the highest versus the lowest intake was 0.93 [95% confidence interval (CI) 0.89-0.98, I(2) = 0%] for dietary fiber, 0.95 (95% CI 0.86-1.06, I(2) = 4%) for fruit fiber, 0.99 (95% CI 0.92-1.07, I(2) = 1%) for vegetable fiber, 0.96 (95% CI 0.90-1.02, I(2) = 5%) for cereal fiber, 0.91 (95% CI 0.84-0.99, I(2) = 7%) for soluble fiber and 0.95 (95% CI 0.89-1.02, I(2) = 0%) for insoluble fiber. The summary RR per 10 g/day of dietary fiber was 0.95 (95% CI 0.91-0.98, I(2) = 0%, P(heterogeneity) = 0.82). In stratified analyses, the inverse association was only observed among studies with a large range (≥13 g/day) or high level of intake (≥25 g/day).

CONCLUSION

In this meta-analysis of prospective studies, there was an inverse association between dietary fiber intake and breast cancer risk.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Imperial College, London, UK. d.aune@imperial.ac.uk

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22234738

Citation

Aune, D, et al. "Dietary Fiber and Breast Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 6, 2012, pp. 1394-402.
Aune D, Chan DS, Greenwood DC, et al. Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. Ann Oncol. 2012;23(6):1394-402.
Aune, D., Chan, D. S., Greenwood, D. C., Vieira, A. R., Rosenblatt, D. A., Vieira, R., & Norat, T. (2012). Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(6), pp. 1394-402. doi:10.1093/annonc/mdr589.
Aune D, et al. Dietary Fiber and Breast Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies. Ann Oncol. 2012;23(6):1394-402. PubMed PMID: 22234738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. AU - Aune,D, AU - Chan,D S M, AU - Greenwood,D C, AU - Vieira,A R, AU - Rosenblatt,D A Navarro, AU - Vieira,R, AU - Norat,T, Y1 - 2012/01/10/ PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/9/21/medline SP - 1394 EP - 402 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 6 N2 - BACKGROUND: Evidence from case-control studies suggest that dietary fiber may be inversely related to breast cancer risk, but it is unclear if this is supported by prospective data. We conducted a systematic review and meta-analysis of the evidence from prospective studies. METHODS: PubMed was searched for prospective studies of fiber intake and breast cancer risk until 31st August 2011. Random effects models were used to estimate summary relative risks (RRs). RESULTS: Sixteen prospective studies were included. The summary RR for the highest versus the lowest intake was 0.93 [95% confidence interval (CI) 0.89-0.98, I(2) = 0%] for dietary fiber, 0.95 (95% CI 0.86-1.06, I(2) = 4%) for fruit fiber, 0.99 (95% CI 0.92-1.07, I(2) = 1%) for vegetable fiber, 0.96 (95% CI 0.90-1.02, I(2) = 5%) for cereal fiber, 0.91 (95% CI 0.84-0.99, I(2) = 7%) for soluble fiber and 0.95 (95% CI 0.89-1.02, I(2) = 0%) for insoluble fiber. The summary RR per 10 g/day of dietary fiber was 0.95 (95% CI 0.91-0.98, I(2) = 0%, P(heterogeneity) = 0.82). In stratified analyses, the inverse association was only observed among studies with a large range (≥13 g/day) or high level of intake (≥25 g/day). CONCLUSION: In this meta-analysis of prospective studies, there was an inverse association between dietary fiber intake and breast cancer risk. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22234738/Dietary_fiber_and_breast_cancer_risk:_a_systematic_review_and_meta_analysis_of_prospective_studies_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr589 DB - PRIME DP - Unbound Medicine ER -