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Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin.
Photochem Photobiol. 2012 May-Jun; 88(3):748-52.PP

Abstract

The present study aimed to evaluate the photoprotective effects of cosmetic formulations containing a dispersion of liposome with magnesium ascorbyl phosphate (MAP), alpha-lipoic acid (ALA) and kinetin, as well as their effects on the hydration and viscoelastic skin properties. The photoprotection was determined in vitro (antioxidant activity) and in vivo on UV-irradiated hairless mouse skin. The hydration effects were performed with the application of the formulations under study on the forearm of human volunteers and skin conditions were analyzed before and after a single application and daily applications during 4 weeks in terms of transepidermal water loss (TEWL), skin moisture and viscoelastic properties. The raw material under study possessed free-radical scavenging activity and the formulation with it protected hairless mouse skin barrier function against UV damage. After 4 weeks of application on human skin, the formulation under study enhanced stratum corneum skin moisture and also showed hydration effects in deeper layers of the skin. Thus, it can be concluded that the cosmetic formulation containing a dispersion of liposome with MAP, ALA and kinetin under study showed photoprotective effects in skin barrier function as well as pronounced hydration effects on human skin, which suggests that this dispersion has potential antiaging effects.

Authors+Show Affiliations

Departamento de Ciências Farmacêuticas da Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil. pmcampos@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22236139

Citation

Campos, Patrícia Maria Berardo Gonçalves Maia, et al. "Efficacy of Cosmetic Formulations Containing Dispersion of Liposome With Magnesium Ascorbyl Phosphate, Alpha-lipoic Acid and Kinetin." Photochemistry and Photobiology, vol. 88, no. 3, 2012, pp. 748-52.
Campos PM, de Camargo Júnior FB, de Andrade JP, et al. Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. Photochem Photobiol. 2012;88(3):748-52.
Campos, P. M., de Camargo Júnior, F. B., de Andrade, J. P., & Gaspar, L. R. (2012). Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. Photochemistry and Photobiology, 88(3), 748-52. https://doi.org/10.1111/j.1751-1097.2012.01086.x
Campos PM, et al. Efficacy of Cosmetic Formulations Containing Dispersion of Liposome With Magnesium Ascorbyl Phosphate, Alpha-lipoic Acid and Kinetin. Photochem Photobiol. 2012 May-Jun;88(3):748-52. PubMed PMID: 22236139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. AU - Campos,Patrícia Maria Berardo Gonçalves Maia, AU - de Camargo Júnior,Flávio Bueno, AU - de Andrade,Jirrah Pedro, AU - Gaspar,Lorena Rigo, Y1 - 2012/02/09/ PY - 2012/1/13/entrez PY - 2012/1/13/pubmed PY - 2012/8/23/medline SP - 748 EP - 52 JF - Photochemistry and photobiology JO - Photochem. Photobiol. VL - 88 IS - 3 N2 - The present study aimed to evaluate the photoprotective effects of cosmetic formulations containing a dispersion of liposome with magnesium ascorbyl phosphate (MAP), alpha-lipoic acid (ALA) and kinetin, as well as their effects on the hydration and viscoelastic skin properties. The photoprotection was determined in vitro (antioxidant activity) and in vivo on UV-irradiated hairless mouse skin. The hydration effects were performed with the application of the formulations under study on the forearm of human volunteers and skin conditions were analyzed before and after a single application and daily applications during 4 weeks in terms of transepidermal water loss (TEWL), skin moisture and viscoelastic properties. The raw material under study possessed free-radical scavenging activity and the formulation with it protected hairless mouse skin barrier function against UV damage. After 4 weeks of application on human skin, the formulation under study enhanced stratum corneum skin moisture and also showed hydration effects in deeper layers of the skin. Thus, it can be concluded that the cosmetic formulation containing a dispersion of liposome with MAP, ALA and kinetin under study showed photoprotective effects in skin barrier function as well as pronounced hydration effects on human skin, which suggests that this dispersion has potential antiaging effects. SN - 1751-1097 UR - https://www.unboundmedicine.com/medline/citation/22236139/Efficacy_of_cosmetic_formulations_containing_dispersion_of_liposome_with_magnesium_ascorbyl_phosphate_alpha_lipoic_acid_and_kinetin_ L2 - https://doi.org/10.1111/j.1751-1097.2012.01086.x DB - PRIME DP - Unbound Medicine ER -