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Evaluation of arsenic, cadmium, lead, and nickel in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A - E) patients and controls.
Clin Lab 2011; 57(11-12):847-57CL

Abstract

BACKGROUND

The aim of present study was to compare the level of arsenic (As), cadmium (Cd), lead (Pb), and nickel (Ni) in biological samples (serum, blood, urine, and scalp hair) of patients suffering from different viral hepatitis (A, B, C, D, and E; n = 521) of both genders, age range 31 - 45 years. For comparative study, 255 age-matched control subjects of both genders residing in the same city were selected as referents.

METHODS

The digests of all biological samples were analysed for Cd, Pb, and Ni by electrothermal atomic absorption spectrometry (ETAAS). The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on the same CRMs.

RESULTS

The results of this study showed that the mean values of As, Cd, Ni, and Pb were higher in blood, serum, and scalp hair samples of hepatitis patients than age-matched control subjects. The urinary levels of these elements were found to be higher in the hepatitis patients than in the age-matched healthy controls (p < 0.001).

CONCLUSIONS

These results are consistent with literature-reported data, confirming that the overload of these toxic elements can directly cause lipid peroxidation and eventually hepatic damage.

Authors+Show Affiliations

Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22239014

Citation

Afridi, Hassan Imran, et al. "Evaluation of Arsenic, Cadmium, Lead, and Nickel in Biological Samples (scalp Hair, Serum, Blood, and Urine) of Pakistani Viral Hepatitis (A - E) Patients and Controls." Clinical Laboratory, vol. 57, no. 11-12, 2011, pp. 847-57.
Afridi HI, Kazi TG, Shah F, et al. Evaluation of arsenic, cadmium, lead, and nickel in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A - E) patients and controls. Clin Lab. 2011;57(11-12):847-57.
Afridi, H. I., Kazi, T. G., Shah, F., Sheikh, H. U., & Kolachi, N. F. (2011). Evaluation of arsenic, cadmium, lead, and nickel in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A - E) patients and controls. Clinical Laboratory, 57(11-12), pp. 847-57.
Afridi HI, et al. Evaluation of Arsenic, Cadmium, Lead, and Nickel in Biological Samples (scalp Hair, Serum, Blood, and Urine) of Pakistani Viral Hepatitis (A - E) Patients and Controls. Clin Lab. 2011;57(11-12):847-57. PubMed PMID: 22239014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of arsenic, cadmium, lead, and nickel in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A - E) patients and controls. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Shah,Faheem, AU - Sheikh,Hafeez-ur-Rehman, AU - Kolachi,Nida Fatima, PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2012/2/14/medline SP - 847 EP - 57 JF - Clinical laboratory JO - Clin. Lab. VL - 57 IS - 11-12 N2 - BACKGROUND: The aim of present study was to compare the level of arsenic (As), cadmium (Cd), lead (Pb), and nickel (Ni) in biological samples (serum, blood, urine, and scalp hair) of patients suffering from different viral hepatitis (A, B, C, D, and E; n = 521) of both genders, age range 31 - 45 years. For comparative study, 255 age-matched control subjects of both genders residing in the same city were selected as referents. METHODS: The digests of all biological samples were analysed for Cd, Pb, and Ni by electrothermal atomic absorption spectrometry (ETAAS). The validity and accuracy of the methodology was checked by using certified reference materials (CRMs) and with those values obtained by conventional wet acid digestion method on the same CRMs. RESULTS: The results of this study showed that the mean values of As, Cd, Ni, and Pb were higher in blood, serum, and scalp hair samples of hepatitis patients than age-matched control subjects. The urinary levels of these elements were found to be higher in the hepatitis patients than in the age-matched healthy controls (p < 0.001). CONCLUSIONS: These results are consistent with literature-reported data, confirming that the overload of these toxic elements can directly cause lipid peroxidation and eventually hepatic damage. SN - 1433-6510 UR - https://www.unboundmedicine.com/medline/citation/22239014/Evaluation_of_arsenic_cadmium_lead_and_nickel_in_biological_samples__scalp_hair_serum_blood_and_urine__of_Pakistani_viral_hepatitis__A___E__patients_and_controls_ L2 - http://www.diseaseinfosearch.org/result/3334 DB - PRIME DP - Unbound Medicine ER -