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Evaluation of arsenic, cadmium, lead, nickel, and zinc in biological samples (scalp hair, blood, and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients.
Clin Lab 2011; 57(11-12):867-78CL

Abstract

BACKGROUND

The consequence of a deficiency in trace elements has been associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) disease progression and mortality. This study examined the association between high scalp hair and blood arsenic, cadmium, lead, and nickel concentrations and opportunistic infections in hospitalized patients with the acquired immune deficiency syndrome (AIDS).

METHODS

The study was performed on sixty two male HIV+ patients (HIV-1) from different cities of Pakistan. The patients were divided in two groups according to secondary infections (tuberculosis, diarrhea, and high fever). The biological samples (scalp hair, blood, and urine) were collected from AIDS patients, and for comparative study 120 healthy subjects (males) of same age group (31 - 45 years), socio-economic status, localities, and dietary habits were also included. The elements in the biological samples were analyzed by electrothermal atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked using certified reference materials (CRMs) and with values obtained by conventional wet acid digestion method on same CRMs.

RESULTS

The results indicated significantly higher levels of As, Cd, Ni, and Pb in the biological samples (scalp hair, blood, and urine) of male HIV-1 patients, compared with control subjects. It was observed that the high levels of these toxic elements may be predictors for secondary infections in HIV-1 patients. There was a significant increase in mean values of As, Cd, Ni, and Pb in whole blood, scalp hair, and urine samples of three groups of AIDS patients as compared to a controlled healthy male group (p < 0.001).

CONCLUSIONS

These data present guidance to clinicians and other professionals investigating toxicity of As, Cd, Ni, and Pb in biological samples of AIDS patients.

Authors+Show Affiliations

Hassan Imran Afridi, Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22239016

Citation

Afridi, Hassan Imran, et al. "Evaluation of Arsenic, Cadmium, Lead, Nickel, and Zinc in Biological Samples (scalp Hair, Blood, and Urine) of Tuberculosis and Diarrhea Male Human Immunodeficiency Virus Patients." Clinical Laboratory, vol. 57, no. 11-12, 2011, pp. 867-78.
Afridi HI, Kazi TG, Kazi N, et al. Evaluation of arsenic, cadmium, lead, nickel, and zinc in biological samples (scalp hair, blood, and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients. Clin Lab. 2011;57(11-12):867-78.
Afridi, H. I., Kazi, T. G., Kazi, N., Kandhro, G. A., Shah, A. Q., Baig, J. A., ... Shah, F. (2011). Evaluation of arsenic, cadmium, lead, nickel, and zinc in biological samples (scalp hair, blood, and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients. Clinical Laboratory, 57(11-12), pp. 867-78.
Afridi HI, et al. Evaluation of Arsenic, Cadmium, Lead, Nickel, and Zinc in Biological Samples (scalp Hair, Blood, and Urine) of Tuberculosis and Diarrhea Male Human Immunodeficiency Virus Patients. Clin Lab. 2011;57(11-12):867-78. PubMed PMID: 22239016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of arsenic, cadmium, lead, nickel, and zinc in biological samples (scalp hair, blood, and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Kazi,Naveed, AU - Kandhro,Ghulam Abbas, AU - Shah,Abdul Qadir, AU - Baig,Jameel Ahmed, AU - Khan,Sumaira, AU - Kolachi,Nida Fatima, AU - Wadhwa,Sham Kumar, AU - Shah,Faheem, PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2012/2/14/medline SP - 867 EP - 78 JF - Clinical laboratory JO - Clin. Lab. VL - 57 IS - 11-12 N2 - BACKGROUND: The consequence of a deficiency in trace elements has been associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) disease progression and mortality. This study examined the association between high scalp hair and blood arsenic, cadmium, lead, and nickel concentrations and opportunistic infections in hospitalized patients with the acquired immune deficiency syndrome (AIDS). METHODS: The study was performed on sixty two male HIV+ patients (HIV-1) from different cities of Pakistan. The patients were divided in two groups according to secondary infections (tuberculosis, diarrhea, and high fever). The biological samples (scalp hair, blood, and urine) were collected from AIDS patients, and for comparative study 120 healthy subjects (males) of same age group (31 - 45 years), socio-economic status, localities, and dietary habits were also included. The elements in the biological samples were analyzed by electrothermal atomic absorption spectrophotometry, prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked using certified reference materials (CRMs) and with values obtained by conventional wet acid digestion method on same CRMs. RESULTS: The results indicated significantly higher levels of As, Cd, Ni, and Pb in the biological samples (scalp hair, blood, and urine) of male HIV-1 patients, compared with control subjects. It was observed that the high levels of these toxic elements may be predictors for secondary infections in HIV-1 patients. There was a significant increase in mean values of As, Cd, Ni, and Pb in whole blood, scalp hair, and urine samples of three groups of AIDS patients as compared to a controlled healthy male group (p < 0.001). CONCLUSIONS: These data present guidance to clinicians and other professionals investigating toxicity of As, Cd, Ni, and Pb in biological samples of AIDS patients. SN - 1433-6510 UR - https://www.unboundmedicine.com/medline/citation/22239016/Evaluation_of_arsenic_cadmium_lead_nickel_and_zinc_in_biological_samples__scalp_hair_blood_and_urine__of_tuberculosis_and_diarrhea_male_human_immunodeficiency_virus_patients_ L2 - http://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -