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Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea.
Clin Lab. 2011; 57(11-12):959-67.CL

Abstract

BACKGROUND

Human enteroviruses (HEVs) are a major cause of herpangina, HFMD (hand, foot, and mouth disease), and other neurological diseases in Seoul, Korea.

METHODS

A total of 56 specimens from hospitalized patients collected from February to December 2009 (37 females and 19 males) in Seoul were tested for HEV from stool, throat swab, and vesicle swab samples taken from patients with herpangina or HFMD using cell culture and RT-PCR in 2009. By the 1D gene, encoding the VP1 capsid protein, seven different HEV genotypes were detected with Coxsackievirus A2, A4, A5, A9, A16 (CA), Coxsackievirus B1 (CB), and Enterovirus 71 (EV71). The most prevalent genotype was CA16 (6, 10.7%), followed by CA2 (4, 7.1%), CA5 (4, 7.1%), EV71 (2, 3.6%), CA4 (1, 1.8%), CA9 (1, 1.8%), and CB1 (1, 1.8%). The 1D gene sequences of two EV71 strains were closely related with one another (98.5% nucleotide similarity) and belonged to the C4 genotype.

CONCLUSIONS

It is important to continuously survey the genetic characteristics of EV71 and CA16 from patients, which will provide useful data that aids in our understanding of HFMD infections in Seoul, Korea and may contribute to future control.

Authors+Show Affiliations

Seoul Metropolitan Government Research Institute of Public Health and Environment, Virus Team, 202-3, Yangjae-Dong, Seocho-Gu, Seoul 137-734, Republic of Korea. sanghun93@seoul.go.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22239028

Citation

Park, S H., et al. "Detection and Characterization of Enterovirus Associated With Herpangina and Hand, Foot, and Mouth Disease in Seoul, Korea." Clinical Laboratory, vol. 57, no. 11-12, 2011, pp. 959-67.
Park SH, Choi SS, Oh SA, et al. Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. Clin Lab. 2011;57(11-12):959-67.
Park, S. H., Choi, S. S., Oh, S. A., Kim, C. K., Cho, S. J., Lee, J. H., Ryu, S. H., Pak, S. H., Jung, S. K., Lee, J. I., Park, G. Y., Choi, S. M., Chae, Y. Z., Kang, B. H., Cheon, D. S., & Kim, H. S. (2011). Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. Clinical Laboratory, 57(11-12), 959-67.
Park SH, et al. Detection and Characterization of Enterovirus Associated With Herpangina and Hand, Foot, and Mouth Disease in Seoul, Korea. Clin Lab. 2011;57(11-12):959-67. PubMed PMID: 22239028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. AU - Park,S H, AU - Choi,S S, AU - Oh,S A, AU - Kim,C K, AU - Cho,S J, AU - Lee,J H, AU - Ryu,S H, AU - Pak,S H, AU - Jung,S K, AU - Lee,J I, AU - Park,G Y, AU - Choi,S M, AU - Chae,Y Z, AU - Kang,B H, AU - Cheon,D S, AU - Kim,H S, PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2012/2/14/medline SP - 959 EP - 67 JF - Clinical laboratory JO - Clin Lab VL - 57 IS - 11-12 N2 - BACKGROUND: Human enteroviruses (HEVs) are a major cause of herpangina, HFMD (hand, foot, and mouth disease), and other neurological diseases in Seoul, Korea. METHODS: A total of 56 specimens from hospitalized patients collected from February to December 2009 (37 females and 19 males) in Seoul were tested for HEV from stool, throat swab, and vesicle swab samples taken from patients with herpangina or HFMD using cell culture and RT-PCR in 2009. By the 1D gene, encoding the VP1 capsid protein, seven different HEV genotypes were detected with Coxsackievirus A2, A4, A5, A9, A16 (CA), Coxsackievirus B1 (CB), and Enterovirus 71 (EV71). The most prevalent genotype was CA16 (6, 10.7%), followed by CA2 (4, 7.1%), CA5 (4, 7.1%), EV71 (2, 3.6%), CA4 (1, 1.8%), CA9 (1, 1.8%), and CB1 (1, 1.8%). The 1D gene sequences of two EV71 strains were closely related with one another (98.5% nucleotide similarity) and belonged to the C4 genotype. CONCLUSIONS: It is important to continuously survey the genetic characteristics of EV71 and CA16 from patients, which will provide useful data that aids in our understanding of HFMD infections in Seoul, Korea and may contribute to future control. SN - 1433-6510 UR - https://www.unboundmedicine.com/medline/citation/22239028/Detection_and_characterization_of_enterovirus_associated_with_herpangina_and_hand_foot_and_mouth_disease_in_Seoul_Korea_ L2 - https://antibodies.cancer.gov/detail/CPTC-MS4A1-1 DB - PRIME DP - Unbound Medicine ER -