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On the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis.
Ann N Y Acad Sci. 2011 Aug; 1230:E1-E10.AN

Abstract

Haemophilus ducreyi and Klebsiella (Calymmatobacterium) granulomatis are sexually transmitted bacteria that cause characteristic, persisting ulceration on external genitals called chancroid and granuloma inguinale, respectively. Those ulcers are endemic in developing countries or exist, as does granuloma inguinale, only in some geographic "hot spots."H. ducreyi is placed in the genus Haemophilus (family Pasteurellacae); however, this phylogenetic position is not obvious. The multiple ways in which the bacterium may be adapted to its econiche through specialized nutrient acquisitions; defenses against the immune system; and virulence factors that increase attachment, fitness, and persistence within genital tissue are discussed below. The analysis of K. granulomatis phylogeny demonstrated a high degree of identity with other Klebsiella species, and the name K. granulomatis comb. nov. was proposed. Because of the difficulty in growing this bacterium on artificial media, its characteristics have not been sufficiently defined. More studies are needed to understand bacterial genetics related to the pathogenesis and evolution of K. granulomatis.

Authors+Show Affiliations

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. teresa.lagergard@microbio.gu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22239475

Citation

Lagergård, Teresa, et al. "On the Evolution of the Sexually Transmitted Bacteria Haemophilus Ducreyi and Klebsiella Granulomatis." Annals of the New York Academy of Sciences, vol. 1230, 2011, pp. E1-E10.
Lagergård T, Bölin I, Lindholm L. On the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis. Ann N Y Acad Sci. 2011;1230:E1-E10.
Lagergård, T., Bölin, I., & Lindholm, L. (2011). On the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis. Annals of the New York Academy of Sciences, 1230, E1-E10. https://doi.org/10.1111/j.1749-6632.2011.06193.x
Lagergård T, Bölin I, Lindholm L. On the Evolution of the Sexually Transmitted Bacteria Haemophilus Ducreyi and Klebsiella Granulomatis. Ann N Y Acad Sci. 2011;1230:E1-E10. PubMed PMID: 22239475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the evolution of the sexually transmitted bacteria Haemophilus ducreyi and Klebsiella granulomatis. AU - Lagergård,Teresa, AU - Bölin,Ingrid, AU - Lindholm,Leif, PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2012/3/6/medline SP - E1 EP - E10 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1230 N2 - Haemophilus ducreyi and Klebsiella (Calymmatobacterium) granulomatis are sexually transmitted bacteria that cause characteristic, persisting ulceration on external genitals called chancroid and granuloma inguinale, respectively. Those ulcers are endemic in developing countries or exist, as does granuloma inguinale, only in some geographic "hot spots."H. ducreyi is placed in the genus Haemophilus (family Pasteurellacae); however, this phylogenetic position is not obvious. The multiple ways in which the bacterium may be adapted to its econiche through specialized nutrient acquisitions; defenses against the immune system; and virulence factors that increase attachment, fitness, and persistence within genital tissue are discussed below. The analysis of K. granulomatis phylogeny demonstrated a high degree of identity with other Klebsiella species, and the name K. granulomatis comb. nov. was proposed. Because of the difficulty in growing this bacterium on artificial media, its characteristics have not been sufficiently defined. More studies are needed to understand bacterial genetics related to the pathogenesis and evolution of K. granulomatis. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/22239475/On_the_evolution_of_the_sexually_transmitted_bacteria_Haemophilus_ducreyi_and_Klebsiella_granulomatis. L2 - https://doi.org/10.1111/j.1749-6632.2011.06193.x DB - PRIME DP - Unbound Medicine ER -