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Ubiquitin and assembly of export competent mRNP.
Biochim Biophys Acta. 2012 Jun; 1819(6):521-30.BB

Abstract

The production of mature and export competent mRNP (mRNA ribonucleoprotein) complexes depends on a series of highly coordinated processing reactions. RNA polymerase II (RNAPII) plays a central role in this process by mediating the sequential recruitment of mRNA maturation and export factors to transcribing genes, thereby establishing a strong functional link between transcription and export through nuclear pore complexes (NPC). Growing evidence indicates that post-translational modifications participate in the dynamic association of processing and export factors with mRNAs ensuring that the transitions and rearrangements undergone by the mRNP occur at the right time and place. This review mainly focuses on the role of ubiquitin conjugation in controlling mRNP assembly and quality control from transcription down to export through the NPC. It emphasizes the central role of ubiquitylation in organizing the chronology of events along this highly dynamic pathway. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.

Authors+Show Affiliations

Institut Jacques Monod, Université Paris Diderot, CNRS, Bâtiment Buffon, 15 rue Hélène Brion, 75205 Paris Cedex 13, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22240387

Citation

Babour, Anna, et al. "Ubiquitin and Assembly of Export Competent MRNP." Biochimica Et Biophysica Acta, vol. 1819, no. 6, 2012, pp. 521-30.
Babour A, Dargemont C, Stutz F. Ubiquitin and assembly of export competent mRNP. Biochim Biophys Acta. 2012;1819(6):521-30.
Babour, A., Dargemont, C., & Stutz, F. (2012). Ubiquitin and assembly of export competent mRNP. Biochimica Et Biophysica Acta, 1819(6), 521-30. https://doi.org/10.1016/j.bbagrm.2011.12.006
Babour A, Dargemont C, Stutz F. Ubiquitin and Assembly of Export Competent MRNP. Biochim Biophys Acta. 2012;1819(6):521-30. PubMed PMID: 22240387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ubiquitin and assembly of export competent mRNP. AU - Babour,Anna, AU - Dargemont,Catherine, AU - Stutz,Françoise, Y1 - 2012/01/03/ PY - 2011/11/11/received PY - 2011/12/20/revised PY - 2011/12/22/accepted PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2013/4/27/medline SP - 521 EP - 30 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1819 IS - 6 N2 - The production of mature and export competent mRNP (mRNA ribonucleoprotein) complexes depends on a series of highly coordinated processing reactions. RNA polymerase II (RNAPII) plays a central role in this process by mediating the sequential recruitment of mRNA maturation and export factors to transcribing genes, thereby establishing a strong functional link between transcription and export through nuclear pore complexes (NPC). Growing evidence indicates that post-translational modifications participate in the dynamic association of processing and export factors with mRNAs ensuring that the transitions and rearrangements undergone by the mRNP occur at the right time and place. This review mainly focuses on the role of ubiquitin conjugation in controlling mRNP assembly and quality control from transcription down to export through the NPC. It emphasizes the central role of ubiquitylation in organizing the chronology of events along this highly dynamic pathway. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/22240387/Ubiquitin_and_assembly_of_export_competent_mRNP_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1874-9399(11)00232-X DB - PRIME DP - Unbound Medicine ER -