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Viral causes of unexplained anterior uveitis in Thailand.
Eye (Lond). 2012 Apr; 26(4):529-34.E

Abstract

AIMS

To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU).

METHODS

Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by real-time polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus.

RESULTS

Viral uveitis determined by either real-time PCR and/or GWC was documented in 20 out of 30 patients (67%). Of 30 paired samples tested by both methods for HSV, CMV, and VZV, 15 showed positive results (CMV (10), HSV (4), and VZV (1)). Real-time PCR was positive in 8/15 (53%), whereas GWC was positive in 10/15 (67%). Out of 10 CMV-positive patients, four had endotheliitis, two had Posner-Schlossman syndrome, and one Fuchs heterochromic uveitis syndrome (FHUS). Five out of 21 (24%) samples tested by GWC for Rubella virus were positive, three of which exhibited clinical features of FHUS.

CONCLUSIONS

Our results indicate that CMV is a major cause of AU in Thailand and show that FHUS can be caused by both CMV and Rubella virus.

Authors+Show Affiliations

Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22241022

Citation

Kongyai, N, et al. "Viral Causes of Unexplained Anterior Uveitis in Thailand." Eye (London, England), vol. 26, no. 4, 2012, pp. 529-34.
Kongyai N, Sirirungsi W, Pathanapitoon K, et al. Viral causes of unexplained anterior uveitis in Thailand. Eye (Lond). 2012;26(4):529-34.
Kongyai, N., Sirirungsi, W., Pathanapitoon, K., Tananuvat, N., Kunavisarut, P., Leechanachai, P., de Groot-Mijnes, J. D., & Rothova, A. (2012). Viral causes of unexplained anterior uveitis in Thailand. Eye (London, England), 26(4), 529-34. https://doi.org/10.1038/eye.2011.363
Kongyai N, et al. Viral Causes of Unexplained Anterior Uveitis in Thailand. Eye (Lond). 2012;26(4):529-34. PubMed PMID: 22241022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Viral causes of unexplained anterior uveitis in Thailand. AU - Kongyai,N, AU - Sirirungsi,W, AU - Pathanapitoon,K, AU - Tananuvat,N, AU - Kunavisarut,P, AU - Leechanachai,P, AU - de Groot-Mijnes,J D F, AU - Rothova,A, Y1 - 2012/01/13/ PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2012/6/6/medline SP - 529 EP - 34 JF - Eye (London, England) JO - Eye (Lond) VL - 26 IS - 4 N2 - AIMS: To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU). METHODS: Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by real-time polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. RESULTS: Viral uveitis determined by either real-time PCR and/or GWC was documented in 20 out of 30 patients (67%). Of 30 paired samples tested by both methods for HSV, CMV, and VZV, 15 showed positive results (CMV (10), HSV (4), and VZV (1)). Real-time PCR was positive in 8/15 (53%), whereas GWC was positive in 10/15 (67%). Out of 10 CMV-positive patients, four had endotheliitis, two had Posner-Schlossman syndrome, and one Fuchs heterochromic uveitis syndrome (FHUS). Five out of 21 (24%) samples tested by GWC for Rubella virus were positive, three of which exhibited clinical features of FHUS. CONCLUSIONS: Our results indicate that CMV is a major cause of AU in Thailand and show that FHUS can be caused by both CMV and Rubella virus. SN - 1476-5454 UR - https://www.unboundmedicine.com/medline/citation/22241022/Viral_causes_of_unexplained_anterior_uveitis_in_Thailand_ L2 - http://dx.doi.org/10.1038/eye.2011.363 DB - PRIME DP - Unbound Medicine ER -