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Racial disparities in Hodgkin's lymphoma: a comprehensive population-based analysis.
Ann Oncol 2012; 23(8):2128-37AO

Abstract

BACKGROUND

Racial disparity has been investigated in a number of cancers; however, there remains a comparative paucity of data in Hodgkin's lymphoma (HL).

PATIENTS AND METHODS

We examined time-, age-, and gender-specific incidence, disease characteristics, and survival across and within races for adolescent/adult HL (age 10-79 years) diagnosed during 1992-2007 in the SEER 13 registries.

RESULTS

A total of 15 662 HL cases were identified [11,211 non-Hispanic whites, 2067 Hispanics, 1662 blacks, and 722 Asian/Pacific Islanders (A/PI)]. Similar to whites, A/PIs had bimodal age-specific incidence, while blacks and Hispanics did not. Further, HL was significantly more common in Hispanics versus whites age>65 years (7.0/1×10(6) versus 4.5/1×10(6), respectively, P<0.01). By place of birth, US-born Hispanics and A/PIs age 20-39 years had higher incidence of HL versus their foreign-born counterparts (P<0.05), however, rates converged age>40 years. Interestingly, from 1992-1997 to 2003-2007, A/PI incidence rates increased >50% (P<0.001). Moreover, this increase was restricted to US-born A/PI. We also identified a number of disease-related differences based on race. Finally, 5-, 10-, and 15-year overall survival rates were inferior for blacks and Hispanics compared with whites (P<0.005 and P<0.001, respectively) and A/PI (P<0.018 and P<0.001, respectively). These differences persisted on multivariate analysis.

CONCLUSION

Collectively, we identified multiple racial disparities, including survival, in adolescent/adult HL.

Authors+Show Affiliations

Division of Hematology/Oncology, The University of Massachusetts Medical School and the UMass Memorial Cancer Center, Worcester, MA 01655, USA. andrew.evens@umassmed.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22241896

Citation

Evens, A M., et al. "Racial Disparities in Hodgkin's Lymphoma: a Comprehensive Population-based Analysis." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 8, 2012, pp. 2128-37.
Evens AM, Antillón M, Aschebrook-Kilfoy B, et al. Racial disparities in Hodgkin's lymphoma: a comprehensive population-based analysis. Ann Oncol. 2012;23(8):2128-37.
Evens, A. M., Antillón, M., Aschebrook-Kilfoy, B., & Chiu, B. C. (2012). Racial disparities in Hodgkin's lymphoma: a comprehensive population-based analysis. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(8), pp. 2128-37. doi:10.1093/annonc/mdr578.
Evens AM, et al. Racial Disparities in Hodgkin's Lymphoma: a Comprehensive Population-based Analysis. Ann Oncol. 2012;23(8):2128-37. PubMed PMID: 22241896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial disparities in Hodgkin's lymphoma: a comprehensive population-based analysis. AU - Evens,A M, AU - Antillón,M, AU - Aschebrook-Kilfoy,B, AU - Chiu,B C-H, Y1 - 2012/01/11/ PY - 2012/1/14/entrez PY - 2012/1/14/pubmed PY - 2012/12/10/medline SP - 2128 EP - 37 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 8 N2 - BACKGROUND: Racial disparity has been investigated in a number of cancers; however, there remains a comparative paucity of data in Hodgkin's lymphoma (HL). PATIENTS AND METHODS: We examined time-, age-, and gender-specific incidence, disease characteristics, and survival across and within races for adolescent/adult HL (age 10-79 years) diagnosed during 1992-2007 in the SEER 13 registries. RESULTS: A total of 15 662 HL cases were identified [11,211 non-Hispanic whites, 2067 Hispanics, 1662 blacks, and 722 Asian/Pacific Islanders (A/PI)]. Similar to whites, A/PIs had bimodal age-specific incidence, while blacks and Hispanics did not. Further, HL was significantly more common in Hispanics versus whites age>65 years (7.0/1×10(6) versus 4.5/1×10(6), respectively, P<0.01). By place of birth, US-born Hispanics and A/PIs age 20-39 years had higher incidence of HL versus their foreign-born counterparts (P<0.05), however, rates converged age>40 years. Interestingly, from 1992-1997 to 2003-2007, A/PI incidence rates increased >50% (P<0.001). Moreover, this increase was restricted to US-born A/PI. We also identified a number of disease-related differences based on race. Finally, 5-, 10-, and 15-year overall survival rates were inferior for blacks and Hispanics compared with whites (P<0.005 and P<0.001, respectively) and A/PI (P<0.018 and P<0.001, respectively). These differences persisted on multivariate analysis. CONCLUSION: Collectively, we identified multiple racial disparities, including survival, in adolescent/adult HL. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22241896/Racial_disparities_in_Hodgkin's_lymphoma:_a_comprehensive_population_based_analysis_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr578 DB - PRIME DP - Unbound Medicine ER -