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Cationic ruthenium(II) catalysts for oxidative C-H/N-H bond functionalizations of anilines with removable directing group: synthesis of indoles in water.
Org Lett. 2012 Feb 03; 14(3):764-7.OL

Abstract

Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ackermann L
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de
Lygin AV
No affiliation info available

MeSH

Aniline CompoundsCatalysisCationsIndolesMolecular StructureOxidation-ReductionRutheniumWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22242646

Citation

Ackermann, Lutz, and Alexander V. Lygin. "Cationic ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines With Removable Directing Group: Synthesis of Indoles in Water." Organic Letters, vol. 14, no. 3, 2012, pp. 764-7.
Ackermann L, Lygin AV. Cationic ruthenium(II) catalysts for oxidative C-H/N-H bond functionalizations of anilines with removable directing group: synthesis of indoles in water. Org Lett. 2012;14(3):764-7.
Ackermann, L., & Lygin, A. V. (2012). Cationic ruthenium(II) catalysts for oxidative C-H/N-H bond functionalizations of anilines with removable directing group: synthesis of indoles in water. Organic Letters, 14(3), 764-7. https://doi.org/10.1021/ol203309y
Ackermann L, Lygin AV. Cationic ruthenium(II) Catalysts for Oxidative C-H/N-H Bond Functionalizations of Anilines With Removable Directing Group: Synthesis of Indoles in Water. Org Lett. 2012 Feb 3;14(3):764-7. PubMed PMID: 22242646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cationic ruthenium(II) catalysts for oxidative C-H/N-H bond functionalizations of anilines with removable directing group: synthesis of indoles in water. AU - Ackermann,Lutz, AU - Lygin,Alexander V, Y1 - 2012/01/13/ PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/5/5/medline SP - 764 EP - 7 JF - Organic letters JO - Org Lett VL - 14 IS - 3 N2 - Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/22242646/Cationic_ruthenium_II__catalysts_for_oxidative_C_H/N_H_bond_functionalizations_of_anilines_with_removable_directing_group:_synthesis_of_indoles_in_water_ L2 - https://doi.org/10.1021/ol203309y DB - PRIME DP - Unbound Medicine ER -