Tags

Type your tag names separated by a space and hit enter

Tissue-specific assimilation, depuration and toxicity of nickel in Mytilus edulis.
Environ Pollut. 2012 Mar; 162:406-12.EP

Abstract

The tissue-specific accumulation and time-dependent depuration of radioactive (63)Ni by the byssus, gut, foot, gills, kidney, adductor muscle and faeces of Mytilus edulis has been investigated using a pulse-chase technique. The rate and extent of depuration of (63)Ni varied between tissues and, after 168 h, the concentration factors and assimilation efficiencies ranged from 1 to 35 L kg(-1) and 5%-13%, respectively. Mussels were also exposed to a range of environmentally-realistic concentrations of dissolved Ni, prior to the analysis of biological endpoints. The clearance rate was concentration-dependent and at the highest concentration decreased by 30%. Neutral red retention (NRR) assays indicated a cytotoxic response and DNA strand breaks were observed in the haemocytes. The association of DNA damage with that of physiological and cytotoxic effects suggests that Ni exerts a significant impact on Mytilus edulis at cellular and genetic levels.

Authors+Show Affiliations

Marine Institute, Portland Square, University of Plymouth, Plymouth, United Kingdom. gmillward@plymouth.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22243892

Citation

Millward, Geoffrey E., et al. "Tissue-specific Assimilation, Depuration and Toxicity of Nickel in Mytilus Edulis." Environmental Pollution (Barking, Essex : 1987), vol. 162, 2012, pp. 406-12.
Millward GE, Kadam S, Jha AN. Tissue-specific assimilation, depuration and toxicity of nickel in Mytilus edulis. Environ Pollut. 2012;162:406-12.
Millward, G. E., Kadam, S., & Jha, A. N. (2012). Tissue-specific assimilation, depuration and toxicity of nickel in Mytilus edulis. Environmental Pollution (Barking, Essex : 1987), 162, 406-12. https://doi.org/10.1016/j.envpol.2011.11.034
Millward GE, Kadam S, Jha AN. Tissue-specific Assimilation, Depuration and Toxicity of Nickel in Mytilus Edulis. Environ Pollut. 2012;162:406-12. PubMed PMID: 22243892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue-specific assimilation, depuration and toxicity of nickel in Mytilus edulis. AU - Millward,Geoffrey E, AU - Kadam,Sandeep, AU - Jha,Awadhesh N, Y1 - 2011/12/28/ PY - 2011/07/14/received PY - 2011/11/18/revised PY - 2011/11/24/accepted PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/5/5/medline SP - 406 EP - 12 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 162 N2 - The tissue-specific accumulation and time-dependent depuration of radioactive (63)Ni by the byssus, gut, foot, gills, kidney, adductor muscle and faeces of Mytilus edulis has been investigated using a pulse-chase technique. The rate and extent of depuration of (63)Ni varied between tissues and, after 168 h, the concentration factors and assimilation efficiencies ranged from 1 to 35 L kg(-1) and 5%-13%, respectively. Mussels were also exposed to a range of environmentally-realistic concentrations of dissolved Ni, prior to the analysis of biological endpoints. The clearance rate was concentration-dependent and at the highest concentration decreased by 30%. Neutral red retention (NRR) assays indicated a cytotoxic response and DNA strand breaks were observed in the haemocytes. The association of DNA damage with that of physiological and cytotoxic effects suggests that Ni exerts a significant impact on Mytilus edulis at cellular and genetic levels. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/22243892/Tissue_specific_assimilation_depuration_and_toxicity_of_nickel_in_Mytilus_edulis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(11)00651-8 DB - PRIME DP - Unbound Medicine ER -