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Effect of long-term intermittent supplementation with multiple micronutrients compared with iron-and-folic acid supplementation on Hb and micronutrient status of non-anaemic adolescent schoolgirls in rural Bangladesh.
Br J Nutr. 2012 Oct 28; 108(8):1484-93.BJ

Abstract

The present study examined whether long-term supplementation with once- and twice-weekly multiple micronutrients (MMN-1 and MMN-2) can improve Hb and micronutrient status more than twice-weekly Fe-folic acid (IFA-2) supplementation in non-anaemic adolescent girls in Bangladesh. An equal number of 324 rural schoolgirls aged 11-17 years were given MMN-1 or MMN-2 or IFA-2 supplements for 52 weeks in a randomised, double-blind trial. Blood samples were collected at baseline, and at 26 and 52 weeks of supplementation. The girls receiving IFA-2 supplements were more likely to be anaemic than the girls receiving MMN-2 supplements for 26 weeks (OR 5·1, 95% CI 1·3, 19·5; P = 0·018). All three supplements reduced Fe deficiency effectively. Both the MMN-1 and MMN-2 groups showed significantly greater improvements in vitamins A, B(2) and C status than the girls in the IFA-2 group, as might be expected. Receiving a MMN-1 supplement was found to be less effective than MMN-2 supplement in improving Fe, vitamins A, B(2) and folic acid status. Receiving micronutrient supplements beyond 26 weeks showed little additional benefit in improving micronutrient status. In conclusion, given twice-weekly for 26 weeks, MMN supplements can improve micronutrient status effectively with no significant increase in Hb concentration compared with IFA supplements in non-anaemic Bangladeshi adolescent girls. However, it significantly reduces the risk of anaemia. Before any recommendations can be made, further research, including into cost-effectiveness, is needed to see whether MMN supplementation has any additional longer-term health benefits over that of IFA supplementation in this population.

Authors+Show Affiliations

Department of Family Sciences, College for Women, Kuwait University, Safat 13060, Kuwait. farukahmed116@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22244349

Citation

Ahmed, Faruk, et al. "Effect of Long-term Intermittent Supplementation With Multiple Micronutrients Compared With Iron-and-folic Acid Supplementation On Hb and Micronutrient Status of Non-anaemic Adolescent Schoolgirls in Rural Bangladesh." The British Journal of Nutrition, vol. 108, no. 8, 2012, pp. 1484-93.
Ahmed F, Khan MR, Akhtaruzzaman M, et al. Effect of long-term intermittent supplementation with multiple micronutrients compared with iron-and-folic acid supplementation on Hb and micronutrient status of non-anaemic adolescent schoolgirls in rural Bangladesh. Br J Nutr. 2012;108(8):1484-93.
Ahmed, F., Khan, M. R., Akhtaruzzaman, M., Karim, R., Williams, G., Banu, C. P., Nahar, B., & Darnton-Hill, I. (2012). Effect of long-term intermittent supplementation with multiple micronutrients compared with iron-and-folic acid supplementation on Hb and micronutrient status of non-anaemic adolescent schoolgirls in rural Bangladesh. The British Journal of Nutrition, 108(8), 1484-93. https://doi.org/10.1017/S0007114511006908
Ahmed F, et al. Effect of Long-term Intermittent Supplementation With Multiple Micronutrients Compared With Iron-and-folic Acid Supplementation On Hb and Micronutrient Status of Non-anaemic Adolescent Schoolgirls in Rural Bangladesh. Br J Nutr. 2012 Oct 28;108(8):1484-93. PubMed PMID: 22244349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of long-term intermittent supplementation with multiple micronutrients compared with iron-and-folic acid supplementation on Hb and micronutrient status of non-anaemic adolescent schoolgirls in rural Bangladesh. AU - Ahmed,Faruk, AU - Khan,Moududur R, AU - Akhtaruzzaman,Mohammad, AU - Karim,Rezaul, AU - Williams,Gail, AU - Banu,Cadi P, AU - Nahar,Badrun, AU - Darnton-Hill,Ian, Y1 - 2012/01/16/ PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/12/27/medline SP - 1484 EP - 93 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 108 IS - 8 N2 - The present study examined whether long-term supplementation with once- and twice-weekly multiple micronutrients (MMN-1 and MMN-2) can improve Hb and micronutrient status more than twice-weekly Fe-folic acid (IFA-2) supplementation in non-anaemic adolescent girls in Bangladesh. An equal number of 324 rural schoolgirls aged 11-17 years were given MMN-1 or MMN-2 or IFA-2 supplements for 52 weeks in a randomised, double-blind trial. Blood samples were collected at baseline, and at 26 and 52 weeks of supplementation. The girls receiving IFA-2 supplements were more likely to be anaemic than the girls receiving MMN-2 supplements for 26 weeks (OR 5·1, 95% CI 1·3, 19·5; P = 0·018). All three supplements reduced Fe deficiency effectively. Both the MMN-1 and MMN-2 groups showed significantly greater improvements in vitamins A, B(2) and C status than the girls in the IFA-2 group, as might be expected. Receiving a MMN-1 supplement was found to be less effective than MMN-2 supplement in improving Fe, vitamins A, B(2) and folic acid status. Receiving micronutrient supplements beyond 26 weeks showed little additional benefit in improving micronutrient status. In conclusion, given twice-weekly for 26 weeks, MMN supplements can improve micronutrient status effectively with no significant increase in Hb concentration compared with IFA supplements in non-anaemic Bangladeshi adolescent girls. However, it significantly reduces the risk of anaemia. Before any recommendations can be made, further research, including into cost-effectiveness, is needed to see whether MMN supplementation has any additional longer-term health benefits over that of IFA supplementation in this population. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/22244349/Effect_of_long_term_intermittent_supplementation_with_multiple_micronutrients_compared_with_iron_and_folic_acid_supplementation_on_Hb_and_micronutrient_status_of_non_anaemic_adolescent_schoolgirls_in_rural_Bangladesh_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511006908/type/journal_article DB - PRIME DP - Unbound Medicine ER -