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Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol.
Fitoterapia. 2012 Apr; 83(3):508-12.F

Abstract

Lippia sidoides Cham. (Verbenaceae) is used in the folk medicine as topical antiseptic in skin and mucous membranes and its therapeutic effect is attributed to the thymol presence. The objective of this work was to verify the chemical composition and antibiotic modifying activity of the essential oil extracted from the leaves of L. sidoides and its major component thymol. The essential oil was obtained by hydrodistillation and analyzed by GC/MS. The synergistic activity was evaluated using gaseous contact method. The essential oil was obtained (yield of 1.06%) and the GC/MS analysis identified the main constituents: thymol (84.9%) and p-cymene (5.33%). The antibiotic modifying activity was verified using the minimal inhibitory dose method and gaseous contact. It verified the interference of essential oil and thymol against all tested aminoglycosides. There were no statistical differences between the activity of the essential oil and thymol against Pseudomonas aeruginosa, indicating this to be the responsible composition for such activity. However, the oil was shown more effective when compared to the thymol against Staphylococcus aureus. The essential oil of L. sidoides and its major component thymol influence the activity of aminoglycosides and may be used as adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.

Links

Publisher Full Text
linkinghub.elsevier.com
linkinghub.elsevier.com

Authors+Show Affiliations

Veras HN
Laboratório de Pesquisa em Produtos Naturais, Universidade Regional do Cariri, Crato-CE, Brazil.
Rodrigues FF
No affiliation info available
Colares AV
No affiliation info available
Menezes IR
No affiliation info available
Coutinho HD
No affiliation info available
Botelho MA
No affiliation info available
Costa JG
No affiliation info available

MeSH

AminoglycosidesAnti-Bacterial AgentsCymenesDrug SynergismLippiaMonoterpenesOils, VolatilePlant ExtractsPlant LeavesPseudomonas aeruginosaRespiratory Tract DiseasesStaphylococcus aureusThymol

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22245085

Citation

Veras, Helenicy N H., et al. "Synergistic Antibiotic Activity of Volatile Compounds From the Essential Oil of Lippia Sidoides and Thymol." Fitoterapia, vol. 83, no. 3, 2012, pp. 508-12.
Veras HN, Rodrigues FF, Colares AV, et al. Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol. Fitoterapia. 2012;83(3):508-12.
Veras, H. N., Rodrigues, F. F., Colares, A. V., Menezes, I. R., Coutinho, H. D., Botelho, M. A., & Costa, J. G. (2012). Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol. Fitoterapia, 83(3), 508-12. https://doi.org/10.1016/j.fitote.2011.12.024
Veras HN, et al. Synergistic Antibiotic Activity of Volatile Compounds From the Essential Oil of Lippia Sidoides and Thymol. Fitoterapia. 2012;83(3):508-12. PubMed PMID: 22245085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol. AU - Veras,Helenicy N H, AU - Rodrigues,Fabíola F G, AU - Colares,Aracélio V, AU - Menezes,Irwin R A, AU - Coutinho,Henrique D M, AU - Botelho,Marco A, AU - Costa,José G M, Y1 - 2012/01/08/ PY - 2011/09/23/received PY - 2011/12/17/revised PY - 2011/12/28/accepted PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/9/5/medline SP - 508 EP - 12 JF - Fitoterapia JO - Fitoterapia VL - 83 IS - 3 N2 - Lippia sidoides Cham. (Verbenaceae) is used in the folk medicine as topical antiseptic in skin and mucous membranes and its therapeutic effect is attributed to the thymol presence. The objective of this work was to verify the chemical composition and antibiotic modifying activity of the essential oil extracted from the leaves of L. sidoides and its major component thymol. The essential oil was obtained by hydrodistillation and analyzed by GC/MS. The synergistic activity was evaluated using gaseous contact method. The essential oil was obtained (yield of 1.06%) and the GC/MS analysis identified the main constituents: thymol (84.9%) and p-cymene (5.33%). The antibiotic modifying activity was verified using the minimal inhibitory dose method and gaseous contact. It verified the interference of essential oil and thymol against all tested aminoglycosides. There were no statistical differences between the activity of the essential oil and thymol against Pseudomonas aeruginosa, indicating this to be the responsible composition for such activity. However, the oil was shown more effective when compared to the thymol against Staphylococcus aureus. The essential oil of L. sidoides and its major component thymol influence the activity of aminoglycosides and may be used as adjuvant in antibiotic therapy against respiratory tract bacterial pathogens. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/22245085/Synergistic_antibiotic_activity_of_volatile_compounds_from_the_essential_oil_of_Lippia_sidoides_and_thymol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(12)00007-X DB - PRIME DP - Unbound Medicine ER -