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The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery.
Am J Ophthalmol. 2012 Apr; 153(4):698-704, 704.e1.AJ

Abstract

PURPOSE

To evaluate the prognostic value of the cone outer segment tips (COST) and other features using spectral-domain optical coherence tomography (SD-OCT) in patients undergoing epiretinal membrane (ERM) surgery.

DESIGN

Retrospective observational case series.

METHODS

Fifty eyes of 49 patients that underwent vitrectomy for idiopathic ERM were studied. Best-corrected visual acuity (BCVA) and SD-OCT images were examined preoperatively and at 1 and 6 months postoperatively. The SD-OCT features evaluated included central foveal thickness (CFT) and the status and defect diameter of the external limiting membrane (ELM), the photoreceptor inner/outer segment (IS/OS) junction, and the COST line. The associations between SD-OCT parameters and BCVA were analyzed.

RESULTS

There was no ELM disruption found, and thus the eyes were categorized into 3 groups: Group A, with a continuous IS/OS and COST line; Group B, with a continuous IS/OS but disrupted COST line; and Group C, with a disrupted IS/OS and COST line. At 6 months, Group A showed a significantly better BCVA than Group B (P<.005), and poorer BCVA was noted in Group C (P=.034). Defect diameters of IS/OS and COST line were also significantly correlated with BCVA postoperatively. The BCVA at 6 months was better in order of Group A, B, and C as assigned at baseline (P<.05) or 1 month (P<.001). There was no significant correlation between CFT and BCVA.

CONCLUSIONS

The status of the COST line, in conjunction with the IS/OS junction, is a useful prognostic factor after ERM surgery.

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Authors+Show Affiliations

Shimozono M
Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Oishi A
No affiliation info available
Hata M
No affiliation info available
Matsuki T
No affiliation info available
Ito S
No affiliation info available
Ishida K
No affiliation info available
Kurimoto Y
No affiliation info available

MeSH

AgedAged, 80 and overCataract ExtractionEpiretinal MembraneFemaleHumansMaleMiddle AgedPrognosisRetinal Cone Photoreceptor CellsRetinal Photoreceptor Cell Outer SegmentRetrospective StudiesTomography, Optical CoherenceVisual AcuityVitrectomy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22245463

Citation

Shimozono, Masataka, et al. "The Significance of Cone Outer Segment Tips as a Prognostic Factor in Epiretinal Membrane Surgery." American Journal of Ophthalmology, vol. 153, no. 4, 2012, pp. 698-704, 704.e1.
Shimozono M, Oishi A, Hata M, et al. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. Am J Ophthalmol. 2012;153(4):698-704, 704.e1.
Shimozono, M., Oishi, A., Hata, M., Matsuki, T., Ito, S., Ishida, K., & Kurimoto, Y. (2012). The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. American Journal of Ophthalmology, 153(4), 698-704, e1. https://doi.org/10.1016/j.ajo.2011.09.011
Shimozono M, et al. The Significance of Cone Outer Segment Tips as a Prognostic Factor in Epiretinal Membrane Surgery. Am J Ophthalmol. 2012;153(4):698-704, 704.e1. PubMed PMID: 22245463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. AU - Shimozono,Masataka, AU - Oishi,Akio, AU - Hata,Masayuki, AU - Matsuki,Takaaki, AU - Ito,Shinichiro, AU - Ishida,Kazuhiro, AU - Kurimoto,Yasuo, Y1 - 2012/01/14/ PY - 2011/06/02/received PY - 2011/09/09/revised PY - 2011/09/11/accepted PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/5/10/medline SP - 698-704, 704.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 153 IS - 4 N2 - PURPOSE: To evaluate the prognostic value of the cone outer segment tips (COST) and other features using spectral-domain optical coherence tomography (SD-OCT) in patients undergoing epiretinal membrane (ERM) surgery. DESIGN: Retrospective observational case series. METHODS: Fifty eyes of 49 patients that underwent vitrectomy for idiopathic ERM were studied. Best-corrected visual acuity (BCVA) and SD-OCT images were examined preoperatively and at 1 and 6 months postoperatively. The SD-OCT features evaluated included central foveal thickness (CFT) and the status and defect diameter of the external limiting membrane (ELM), the photoreceptor inner/outer segment (IS/OS) junction, and the COST line. The associations between SD-OCT parameters and BCVA were analyzed. RESULTS: There was no ELM disruption found, and thus the eyes were categorized into 3 groups: Group A, with a continuous IS/OS and COST line; Group B, with a continuous IS/OS but disrupted COST line; and Group C, with a disrupted IS/OS and COST line. At 6 months, Group A showed a significantly better BCVA than Group B (P<.005), and poorer BCVA was noted in Group C (P=.034). Defect diameters of IS/OS and COST line were also significantly correlated with BCVA postoperatively. The BCVA at 6 months was better in order of Group A, B, and C as assigned at baseline (P<.05) or 1 month (P<.001). There was no significant correlation between CFT and BCVA. CONCLUSIONS: The status of the COST line, in conjunction with the IS/OS junction, is a useful prognostic factor after ERM surgery. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/22245463/The_significance_of_cone_outer_segment_tips_as_a_prognostic_factor_in_epiretinal_membrane_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(11)00719-7 DB - PRIME DP - Unbound Medicine ER -