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Population data of 21 non-CODIS STR loci in Han population of northern China.
Int J Legal Med. 2012 Jul; 126(4):659-64.IJ

Abstract

Allele frequencies and forensic statistics of 21 autosomal short tandem repeat loci (i.e., D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500) were estimated in Han population from northern China (n = 220). Significant deviation from Hardy-Weinberg equilibrium was detected only for D22S1045. The observed heterozygosity, the expected heterozygosity, the discrimination power, the probability of paternity exclusion in trios, the probability of paternity exclusion in duos and the polymorphic information content ranged from 0.591 to 0.836, 0.594 to 0.830, 0.762 to 0.948, 0.341 to 0.659, 0.189 to 0.487 and 0.535 to 0.807, respectively. Triallelic patterns were observed at D19S433 and D10S1435. Mutations occurred at D22ATA63, D10S1248, D19S433 and D14S1434 loci with all single-step mutations. The expected mutation rates of these four loci are 0.0042 with 95% confidence interval [0.0001, 0.0232] in a total of 238 meioses. Our results show that these 21 non-CODIS STR loci are highly polymorphic and can be useful for human identification and kinship analysis in Northern Han population in China.

Authors+Show Affiliations

Shanghai Key Laboratory of Forensic Medicine, Shanghai, 200063, PR China. yuanliwcy@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22245836

Citation

Yuan, Li, et al. "Population Data of 21 non-CODIS STR Loci in Han Population of Northern China." International Journal of Legal Medicine, vol. 126, no. 4, 2012, pp. 659-64.
Yuan L, Ge J, Lu D, et al. Population data of 21 non-CODIS STR loci in Han population of northern China. Int J Legal Med. 2012;126(4):659-64.
Yuan, L., Ge, J., Lu, D., & Yang, X. (2012). Population data of 21 non-CODIS STR loci in Han population of northern China. International Journal of Legal Medicine, 126(4), 659-64. https://doi.org/10.1007/s00414-011-0664-4
Yuan L, et al. Population Data of 21 non-CODIS STR Loci in Han Population of Northern China. Int J Legal Med. 2012;126(4):659-64. PubMed PMID: 22245836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Population data of 21 non-CODIS STR loci in Han population of northern China. AU - Yuan,Li, AU - Ge,Jianye, AU - Lu,Di, AU - Yang,Xue, Y1 - 2012/01/13/ PY - 2011/10/27/received PY - 2011/12/27/accepted PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/12/10/medline SP - 659 EP - 64 JF - International journal of legal medicine JO - Int J Legal Med VL - 126 IS - 4 N2 - Allele frequencies and forensic statistics of 21 autosomal short tandem repeat loci (i.e., D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D19S433, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435 and D5S2500) were estimated in Han population from northern China (n = 220). Significant deviation from Hardy-Weinberg equilibrium was detected only for D22S1045. The observed heterozygosity, the expected heterozygosity, the discrimination power, the probability of paternity exclusion in trios, the probability of paternity exclusion in duos and the polymorphic information content ranged from 0.591 to 0.836, 0.594 to 0.830, 0.762 to 0.948, 0.341 to 0.659, 0.189 to 0.487 and 0.535 to 0.807, respectively. Triallelic patterns were observed at D19S433 and D10S1435. Mutations occurred at D22ATA63, D10S1248, D19S433 and D14S1434 loci with all single-step mutations. The expected mutation rates of these four loci are 0.0042 with 95% confidence interval [0.0001, 0.0232] in a total of 238 meioses. Our results show that these 21 non-CODIS STR loci are highly polymorphic and can be useful for human identification and kinship analysis in Northern Han population in China. SN - 1437-1596 UR - https://www.unboundmedicine.com/medline/citation/22245836/Population_data_of_21_non_CODIS_STR_loci_in_Han_population_of_northern_China_ L2 - https://dx.doi.org/10.1007/s00414-011-0664-4 DB - PRIME DP - Unbound Medicine ER -