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Fast disintegrating tablets: Opportunity in drug delivery system.
J Adv Pharm Technol Res. 2011 Oct; 2(4):223-35.JA

Abstract

Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray drying and use of disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and dissolution are also discussed.

Authors+Show Affiliations

Department of Pharmaceutics, B. S. Anangpuria Institute of Pharmacy, Alampur, Faridabad, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22247889

Citation

Parkash, Ved, et al. "Fast Disintegrating Tablets: Opportunity in Drug Delivery System." Journal of Advanced Pharmaceutical Technology & Research, vol. 2, no. 4, 2011, pp. 223-35.
Parkash V, Maan S, Deepika , et al. Fast disintegrating tablets: Opportunity in drug delivery system. J Adv Pharm Technol Res. 2011;2(4):223-35.
Parkash, V., Maan, S., Deepika, ., Yadav, S. K., Hemlata, ., & Jogpal, V. (2011). Fast disintegrating tablets: Opportunity in drug delivery system. Journal of Advanced Pharmaceutical Technology & Research, 2(4), 223-35. https://doi.org/10.4103/2231-4040.90877
Parkash V, et al. Fast Disintegrating Tablets: Opportunity in Drug Delivery System. J Adv Pharm Technol Res. 2011;2(4):223-35. PubMed PMID: 22247889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast disintegrating tablets: Opportunity in drug delivery system. AU - Parkash,Ved, AU - Maan,Saurabh, AU - Deepika,, AU - Yadav,Shiv Kumar, AU - Hemlata,, AU - Jogpal,Vikas, PY - 2012/1/17/entrez PY - 2012/1/17/pubmed PY - 2012/1/17/medline KW - Fast dissolving tablets KW - freeze drying KW - spray drying KW - taste masking SP - 223 EP - 35 JF - Journal of advanced pharmaceutical technology & research JO - J Adv Pharm Technol Res VL - 2 IS - 4 N2 - Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray drying and use of disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and dissolution are also discussed. SN - 0976-2094 UR - https://www.unboundmedicine.com/medline/citation/22247889/Fast_disintegrating_tablets:_Opportunity_in_drug_delivery_system_ L2 - http://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=4;spage=223;epage=235;aulast=Parkash DB - PRIME DP - Unbound Medicine ER -
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