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The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children.
Saudi J Gastroenterol 2012 Jan-Feb; 18(1):44-9SJ

Abstract

BACKGROUND/AIM

To study the prevalence of metabolic syndrome (MS), insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in overweight/obese children with clinical hepatomegaly and/or raised alanine aminotransferase (ALT).

PATIENTS AND METHODS

Thirty-three overweight and obese children, aged 2-13 years, presenting with hepatomegaly and/or raised ALT, were studied for the prevalence of MS, IR and NAFLD. Laboratory analysis included fasting blood glucose, serum insulin, serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and liver biochemical profile, in addition to liver ultrasound and liver biopsy.

RESULTS

Twenty patients (60.6%) were labeled with MS. IR was present in 16 (48.4%). Fifteen (44%) patients had biopsy-proven NAFLD. Patients with MS were more likely to have NAFLD by biopsy (P=0.001). Children with NAFLD had significantly higher body mass index, waist circumference, ALT, total cholesterol, LDL-c, TG, fasting insulin, and lower HDL-c compared to patients with normal liver histology (P< 0.05) and fitted more with the criteria of MS (80% vs. 44%). IR was significantly more common among NAFLD patients (73% vs. 28%).

CONCLUSION

There is a close association between obesity, MS, IR and NAFLD. Obese children with clinical or biochemical hepatic abnormalities are prone to suffer from MS, IR and NAFLD.

Authors+Show Affiliations

Department of Pediatrics, Cairo University, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22249092

Citation

El-Koofy, Nehal M., et al. "The Association of Metabolic Syndrome, Insulin Resistance and Non-alcoholic Fatty Liver Disease in Overweight/obese Children." Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, vol. 18, no. 1, 2012, pp. 44-9.
El-Koofy NM, Anwar GM, El-Raziky MS, et al. The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children. Saudi J Gastroenterol. 2012;18(1):44-9.
El-Koofy, N. M., Anwar, G. M., El-Raziky, M. S., El-Hennawy, A. M., El-Mougy, F. M., El-Karaksy, H. M., ... Helmy, H. M. (2012). The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children. Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 18(1), pp. 44-9. doi:10.4103/1319-3767.91738.
El-Koofy NM, et al. The Association of Metabolic Syndrome, Insulin Resistance and Non-alcoholic Fatty Liver Disease in Overweight/obese Children. Saudi J Gastroenterol. 2012;18(1):44-9. PubMed PMID: 22249092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children. AU - El-Koofy,Nehal M, AU - Anwar,Ghada M, AU - El-Raziky,Mona S, AU - El-Hennawy,Ahmad M, AU - El-Mougy,Fatma M, AU - El-Karaksy,Hanaa M, AU - Hassanin,Fetouh M, AU - Helmy,Heba M, PY - 2012/1/18/entrez PY - 2012/1/18/pubmed PY - 2012/7/20/medline SP - 44 EP - 9 JF - Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association JO - Saudi J Gastroenterol VL - 18 IS - 1 N2 - BACKGROUND/AIM: To study the prevalence of metabolic syndrome (MS), insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in overweight/obese children with clinical hepatomegaly and/or raised alanine aminotransferase (ALT). PATIENTS AND METHODS: Thirty-three overweight and obese children, aged 2-13 years, presenting with hepatomegaly and/or raised ALT, were studied for the prevalence of MS, IR and NAFLD. Laboratory analysis included fasting blood glucose, serum insulin, serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and liver biochemical profile, in addition to liver ultrasound and liver biopsy. RESULTS: Twenty patients (60.6%) were labeled with MS. IR was present in 16 (48.4%). Fifteen (44%) patients had biopsy-proven NAFLD. Patients with MS were more likely to have NAFLD by biopsy (P=0.001). Children with NAFLD had significantly higher body mass index, waist circumference, ALT, total cholesterol, LDL-c, TG, fasting insulin, and lower HDL-c compared to patients with normal liver histology (P< 0.05) and fitted more with the criteria of MS (80% vs. 44%). IR was significantly more common among NAFLD patients (73% vs. 28%). CONCLUSION: There is a close association between obesity, MS, IR and NAFLD. Obese children with clinical or biochemical hepatic abnormalities are prone to suffer from MS, IR and NAFLD. SN - 1998-4049 UR - https://www.unboundmedicine.com/medline/citation/22249092/The_association_of_metabolic_syndrome_insulin_resistance_and_non_alcoholic_fatty_liver_disease_in_overweight/obese_children_ L2 - http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=1;spage=44;epage=49;aulast=El-Koofy DB - PRIME DP - Unbound Medicine ER -