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Excitotoxic lesions of the medial amygdala attenuate olfactory fear-potentiated startle and conditioned freezing behavior.
Behav Brain Res. 2012 Apr 15; 229(2):427-32.BB

Abstract

Conditioned fear is supported by a distributed network that prominently includes lateral and central amygdaloid nuclei. The role of corticomedial amygdaloid nuclei, including the medial nucleus (MeA), in fear acquisition or expression is not well understood. The present study demonstrates that pre-training excitotoxic lesions directed at the MeA disrupted both fear-potentiated startle (FPS) and conditioned freezing behavior elicited by re-exposure to a discrete olfactory cue. In contrast, such lesions had no effect on baseline startle reactivity or contextual FPS. These findings suggest that the MeA plays an obligatory role in either the acquisition or expression of olfactory conditioned fear, not limited by form of behavioral expression, but is not necessary for contextual conditioned fear.

Authors+Show Affiliations

Department of Psychology, Drew University, 36 Madison Avenue, Madison, NJ 07940, USA. gcousens@drew.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22249137

Citation

Cousens, Graham A., et al. "Excitotoxic Lesions of the Medial Amygdala Attenuate Olfactory Fear-potentiated Startle and Conditioned Freezing Behavior." Behavioural Brain Research, vol. 229, no. 2, 2012, pp. 427-32.
Cousens GA, Kearns A, Laterza F, et al. Excitotoxic lesions of the medial amygdala attenuate olfactory fear-potentiated startle and conditioned freezing behavior. Behav Brain Res. 2012;229(2):427-32.
Cousens, G. A., Kearns, A., Laterza, F., & Tundidor, J. (2012). Excitotoxic lesions of the medial amygdala attenuate olfactory fear-potentiated startle and conditioned freezing behavior. Behavioural Brain Research, 229(2), 427-32. https://doi.org/10.1016/j.bbr.2012.01.011
Cousens GA, et al. Excitotoxic Lesions of the Medial Amygdala Attenuate Olfactory Fear-potentiated Startle and Conditioned Freezing Behavior. Behav Brain Res. 2012 Apr 15;229(2):427-32. PubMed PMID: 22249137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excitotoxic lesions of the medial amygdala attenuate olfactory fear-potentiated startle and conditioned freezing behavior. AU - Cousens,Graham A, AU - Kearns,Amanda, AU - Laterza,Francesco, AU - Tundidor,Jillian, Y1 - 2012/01/12/ PY - 2011/09/13/received PY - 2012/01/03/revised PY - 2012/01/04/accepted PY - 2012/1/18/entrez PY - 2012/1/18/pubmed PY - 2012/7/18/medline SP - 427 EP - 32 JF - Behavioural brain research JO - Behav Brain Res VL - 229 IS - 2 N2 - Conditioned fear is supported by a distributed network that prominently includes lateral and central amygdaloid nuclei. The role of corticomedial amygdaloid nuclei, including the medial nucleus (MeA), in fear acquisition or expression is not well understood. The present study demonstrates that pre-training excitotoxic lesions directed at the MeA disrupted both fear-potentiated startle (FPS) and conditioned freezing behavior elicited by re-exposure to a discrete olfactory cue. In contrast, such lesions had no effect on baseline startle reactivity or contextual FPS. These findings suggest that the MeA plays an obligatory role in either the acquisition or expression of olfactory conditioned fear, not limited by form of behavioral expression, but is not necessary for contextual conditioned fear. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22249137/Excitotoxic_lesions_of_the_medial_amygdala_attenuate_olfactory_fear_potentiated_startle_and_conditioned_freezing_behavior_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00029-0 DB - PRIME DP - Unbound Medicine ER -