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Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men.
Hum Exp Toxicol. 2012 Jul; 31(7):652-61.HE

Abstract

Chronic alcohol consumption is a major reason for several human diseases, and alcoholism has been associated with a variety of societal problems. Changes in fatty acid metabolism in alcoholics and its effects leading to membrane damage are largely unknown. Therefore, we aimed to investigate the fatty acid composition of erythrocyte membrane phospholipids in relation with plasma lipid profile and other plasma metabolites in chronic alcoholics in comparison with controls. We systematically measured the levels of glucose, lactate and pyruvate in the blood and free amino acids, free fatty acids, mucoproteins and glycolipids, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein (VLDL) cholesterol and triglycerides (TG) in plasma of chronic alcoholics and controls. Furthermore, we measured fatty acid composition by gas chromatographic analysis. The fatty acid composition clearly revealed certain changes in chronic alcoholic erythrocyte membrane, chiefly increments in C16:0 and a decrease in C22:4 and C22:6 fatty acids besides the presence of unidentified fatty acids, probably C-24 or C-26 fatty acids. In addition, a significant increase in blood lactate, decrease in blood pyruvate and increased levels of free amino acids and free fatty acids, mucoproteins, VLDL cholesterol, TG and HDL-C in chronic alcoholics were observed with no significant change in plasma TC, LDL-C and glycolipids when compared with controls. Alcohol-induced alterations in plasma and erythrocyte membranes of chronic alcoholics in the present study might be an adaptive response to counteract the deleterious effects of alcohol. The implications of our findings warrant further investigation and needs further in-depth study to explore the mechanisms of alcohol-induced membrane changes.

Authors+Show Affiliations

Department of Genetics, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22249389

Citation

Maturu, Paramahamsa, and Nallanchakravarthula Varadacharyulu. "Adaptive Changes in Fatty Acid Profile of Erythrocyte Membrane in Relation to Plasma and Red Cell Metabolic Changes in Chronic Alcoholic Men." Human & Experimental Toxicology, vol. 31, no. 7, 2012, pp. 652-61.
Maturu P, Varadacharyulu N. Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men. Hum Exp Toxicol. 2012;31(7):652-61.
Maturu, P., & Varadacharyulu, N. (2012). Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men. Human & Experimental Toxicology, 31(7), 652-61. https://doi.org/10.1177/0960327111432504
Maturu P, Varadacharyulu N. Adaptive Changes in Fatty Acid Profile of Erythrocyte Membrane in Relation to Plasma and Red Cell Metabolic Changes in Chronic Alcoholic Men. Hum Exp Toxicol. 2012;31(7):652-61. PubMed PMID: 22249389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adaptive changes in fatty acid profile of erythrocyte membrane in relation to plasma and red cell metabolic changes in chronic alcoholic men. AU - Maturu,Paramahamsa, AU - Varadacharyulu,Nallanchakravarthula, Y1 - 2012/01/16/ PY - 2012/1/18/entrez PY - 2012/1/18/pubmed PY - 2012/12/14/medline SP - 652 EP - 61 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 31 IS - 7 N2 - Chronic alcohol consumption is a major reason for several human diseases, and alcoholism has been associated with a variety of societal problems. Changes in fatty acid metabolism in alcoholics and its effects leading to membrane damage are largely unknown. Therefore, we aimed to investigate the fatty acid composition of erythrocyte membrane phospholipids in relation with plasma lipid profile and other plasma metabolites in chronic alcoholics in comparison with controls. We systematically measured the levels of glucose, lactate and pyruvate in the blood and free amino acids, free fatty acids, mucoproteins and glycolipids, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein (VLDL) cholesterol and triglycerides (TG) in plasma of chronic alcoholics and controls. Furthermore, we measured fatty acid composition by gas chromatographic analysis. The fatty acid composition clearly revealed certain changes in chronic alcoholic erythrocyte membrane, chiefly increments in C16:0 and a decrease in C22:4 and C22:6 fatty acids besides the presence of unidentified fatty acids, probably C-24 or C-26 fatty acids. In addition, a significant increase in blood lactate, decrease in blood pyruvate and increased levels of free amino acids and free fatty acids, mucoproteins, VLDL cholesterol, TG and HDL-C in chronic alcoholics were observed with no significant change in plasma TC, LDL-C and glycolipids when compared with controls. Alcohol-induced alterations in plasma and erythrocyte membranes of chronic alcoholics in the present study might be an adaptive response to counteract the deleterious effects of alcohol. The implications of our findings warrant further investigation and needs further in-depth study to explore the mechanisms of alcohol-induced membrane changes. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/22249389/Adaptive_changes_in_fatty_acid_profile_of_erythrocyte_membrane_in_relation_to_plasma_and_red_cell_metabolic_changes_in_chronic_alcoholic_men_ L2 - https://journals.sagepub.com/doi/10.1177/0960327111432504?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -