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Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder.
Psychiatry Clin Neurosci. 2012 Feb; 66(1):53-63.PC

Abstract

AIM

To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficit-hyperactivity disorder (ADHD).

METHODS

A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver's satisfaction rate, treatment adherence, and frequency of adverse effects.

RESULTS

According to the SNAP-IV-C scores, the remission rate was 30.72%, and the recovery rate was 16.38%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD.

CONCLUSION

OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment.

Authors+Show Affiliations

Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22250610

Citation

Tzang, Ruu-Fen, et al. "Naturalistic Exploration of the Effect of Osmotic Release Oral System-methylphenidate On Remission Rate and Functional Improvement in Taiwanese Children With Attention-deficit-hyperactivity Disorder." Psychiatry and Clinical Neurosciences, vol. 66, no. 1, 2012, pp. 53-63.
Tzang RF, Wang YC, Yeh CB, et al. Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder. Psychiatry Clin Neurosci. 2012;66(1):53-63.
Tzang, R. F., Wang, Y. C., Yeh, C. B., Hsu, C. D., Liang, H. Y., Yang, P. C., Liu, H. J., Huang, Y. S., Cheng, H., Hsu, Y. C., Liu, S. I., Pan, C. H., Huang, Y. F., Huang, C. F., Wu, Y. Y., Huang, Y. H., Liu, H. C., & Chang, H. L. (2012). Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder. Psychiatry and Clinical Neurosciences, 66(1), 53-63. https://doi.org/10.1111/j.1440-1819.2011.02289.x
Tzang RF, et al. Naturalistic Exploration of the Effect of Osmotic Release Oral System-methylphenidate On Remission Rate and Functional Improvement in Taiwanese Children With Attention-deficit-hyperactivity Disorder. Psychiatry Clin Neurosci. 2012;66(1):53-63. PubMed PMID: 22250610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder. AU - Tzang,Ruu-Fen, AU - Wang,Ya-Ching, AU - Yeh,Chin-Bin, AU - Hsu,Cheng-Dien, AU - Liang,Hsin-Yi, AU - Yang,Pin-Chen, AU - Liu,Hung-Jen, AU - Huang,Yu-Shu, AU - Cheng,Helen, AU - Hsu,Ya-Chen, AU - Liu,Shen-Ing, AU - Pan,Chia-Ho, AU - Huang,Ya-Fen, AU - Huang,Chi-Fen, AU - Wu,Yu-Yu, AU - Huang,Yu-Hsin, AU - Liu,Hui-Ching, AU - Chang,Hsueh-Ling, PY - 2012/1/19/entrez PY - 2012/1/19/pubmed PY - 2012/5/19/medline SP - 53 EP - 63 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin Neurosci VL - 66 IS - 1 N2 - AIM: To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficit-hyperactivity disorder (ADHD). METHODS: A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver's satisfaction rate, treatment adherence, and frequency of adverse effects. RESULTS: According to the SNAP-IV-C scores, the remission rate was 30.72%, and the recovery rate was 16.38%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD. CONCLUSION: OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment. SN - 1440-1819 UR - https://www.unboundmedicine.com/medline/citation/22250610/Naturalistic_exploration_of_the_effect_of_osmotic_release_oral_system_methylphenidate_on_remission_rate_and_functional_improvement_in_Taiwanese_children_with_attention_deficit_hyperactivity_disorder_ L2 - https://doi.org/10.1111/j.1440-1819.2011.02289.x DB - PRIME DP - Unbound Medicine ER -