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Effect of switching from telmisartan, valsartan, olmesartan, or losartan to candesartan on morning hypertension.
Clin Exp Hypertens. 2012; 34(2):86-91.CE

Abstract

The Candesartan Cooperative Research of Therapy Design for Early Morning Hypertension in CHIBA was designed to investigate whether switching from angiotensin II receptor blockers (ARBs) except candesartan to candesartan might be effective in Japanese patients with morning hypertension. Seventy-eight mild to moderate hypertensive patients, who were treated with the standard doses of ARBs except candesartan (losartan, 50 mg; valsartan, 80 mg; telmisartan, 40 mg; or olmesartan, 20 mg), were entered into 12-week treatment period with candesartan 8 mg according to a multicenter, open-label design. Morning and office blood pressures (BPs) were significantly reduced (morning, -10.1 ± 10.5/-4.5 ± 8.4 mm Hg; office, -13.1 ± 17.3/-6.2 ± 11.3 mm Hg) after medication change. Target BPs (morning BPs ≤ 135/85 mm Hg and office BPs ≤ 140/90 mm Hg) achievement rates were 42.9% in the morning and 64.3% at office. No adverse events were recognized in all patients. Candesartan treatment significantly reduced the morning and office BPs compared with other ARBs in Japanese patients with morning hypertension.

Authors+Show Affiliations

Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

22251314

Citation

Hasegawa, Hiroshi, et al. "Effect of Switching From Telmisartan, Valsartan, Olmesartan, or Losartan to Candesartan On Morning Hypertension." Clinical and Experimental Hypertension (New York, N.Y. : 1993), vol. 34, no. 2, 2012, pp. 86-91.
Hasegawa H, Takano H, Kameda Y, et al. Effect of switching from telmisartan, valsartan, olmesartan, or losartan to candesartan on morning hypertension. Clin Exp Hypertens. 2012;34(2):86-91.
Hasegawa, H., Takano, H., Kameda, Y., Kubota, A., Kobayashi, Y., & Komuro, I. (2012). Effect of switching from telmisartan, valsartan, olmesartan, or losartan to candesartan on morning hypertension. Clinical and Experimental Hypertension (New York, N.Y. : 1993), 34(2), 86-91. https://doi.org/10.3109/10641963.2011.628729
Hasegawa H, et al. Effect of Switching From Telmisartan, Valsartan, Olmesartan, or Losartan to Candesartan On Morning Hypertension. Clin Exp Hypertens. 2012;34(2):86-91. PubMed PMID: 22251314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of switching from telmisartan, valsartan, olmesartan, or losartan to candesartan on morning hypertension. AU - Hasegawa,Hiroshi, AU - Takano,Hiroyuki, AU - Kameda,Yoshihito, AU - Kubota,Akihiko, AU - Kobayashi,Yoshio, AU - Komuro,Issei, Y1 - 2012/01/17/ PY - 2012/1/19/entrez PY - 2012/1/19/pubmed PY - 2012/8/10/medline SP - 86 EP - 91 JF - Clinical and experimental hypertension (New York, N.Y. : 1993) JO - Clin Exp Hypertens VL - 34 IS - 2 N2 - The Candesartan Cooperative Research of Therapy Design for Early Morning Hypertension in CHIBA was designed to investigate whether switching from angiotensin II receptor blockers (ARBs) except candesartan to candesartan might be effective in Japanese patients with morning hypertension. Seventy-eight mild to moderate hypertensive patients, who were treated with the standard doses of ARBs except candesartan (losartan, 50 mg; valsartan, 80 mg; telmisartan, 40 mg; or olmesartan, 20 mg), were entered into 12-week treatment period with candesartan 8 mg according to a multicenter, open-label design. Morning and office blood pressures (BPs) were significantly reduced (morning, -10.1 ± 10.5/-4.5 ± 8.4 mm Hg; office, -13.1 ± 17.3/-6.2 ± 11.3 mm Hg) after medication change. Target BPs (morning BPs ≤ 135/85 mm Hg and office BPs ≤ 140/90 mm Hg) achievement rates were 42.9% in the morning and 64.3% at office. No adverse events were recognized in all patients. Candesartan treatment significantly reduced the morning and office BPs compared with other ARBs in Japanese patients with morning hypertension. SN - 1525-6006 UR - https://www.unboundmedicine.com/medline/citation/22251314/Effect_of_switching_from_telmisartan_valsartan_olmesartan_or_losartan_to_candesartan_on_morning_hypertension_ L2 - https://www.tandfonline.com/doi/full/10.3109/10641963.2011.628729 DB - PRIME DP - Unbound Medicine ER -