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Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome.
Int J Psychophysiol. 2012 Apr; 84(1):39-44.IJ

Abstract

OBJECTIVE

In this study, we investigated levels and relative ratios of adrenal hormones (including cortisol, dehydroepiandrosterone [DHEA], and DHEA-sulfate [DHEA-S]) and their psychophysiological correlates under acute psychosocial stress in individuals with irritable bowel syndrome (IBS).

METHODS

Fifty-three college students participated in the study (male: 42, female: 11; mean age: 22.64years), including 13 individuals with IBS (IBS group) and 40 individuals without IBS (control group). The participants were exposed to a standardized laboratory stressor, which included delivering a speech and performing a mental arithmetic task. We measured subjective stress levels and salivary cortisol, DHEA, and DHEA-S levels at relevant time points before, during, and after the tasks.

RESULTS

DHEA-S level and the DHEA-S/DHEA ratio in the IBS group were significantly lower than those in the control group, and the cortisol/DHEA-S ratio in the IBS group was higher than that in the control group throughout the experiment. In the IBS group, the appraisal of a threat was positively correlated with cortisol levels (r=0.61), and the appraisal of controllability was negatively correlated with cortisol levels (r=-0.64) and with the cortisol/DHEA ratio (r=-0.71). The control group showed a significant positive correlation between the appraisal of threat and cortisol levels (r=0.32).

CONCLUSION

The present study indicates that individuals with IBS had lower DHEA-S levels, and that their stressful cognitive appraisals under acute psychosocial stress caused the effects of cortisol to dominate. This adrenal hormone response may be involved in exacerbating abdominal symptoms in individuals with IBS.

Authors+Show Affiliations

Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya-ku, Tokyo Japan. nagisa618@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22251450

Citation

Sugaya, Nagisa, et al. "Adrenal Hormone Response and Psychophysiological Correlates Under Psychosocial Stress in Individuals With Irritable Bowel Syndrome." International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology, vol. 84, no. 1, 2012, pp. 39-44.
Sugaya N, Izawa S, Kimura K, et al. Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome. Int J Psychophysiol. 2012;84(1):39-44.
Sugaya, N., Izawa, S., Kimura, K., Ogawa, N., Yamada, K. C., Shirotsuki, K., Mikami, I., Hirata, K., Nagano, Y., Nomura, S., & Shimada, H. (2012). Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome. International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology, 84(1), 39-44. https://doi.org/10.1016/j.ijpsycho.2012.01.006
Sugaya N, et al. Adrenal Hormone Response and Psychophysiological Correlates Under Psychosocial Stress in Individuals With Irritable Bowel Syndrome. Int J Psychophysiol. 2012;84(1):39-44. PubMed PMID: 22251450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome. AU - Sugaya,Nagisa, AU - Izawa,Shuhei, AU - Kimura,Kenta, AU - Ogawa,Namiko, AU - Yamada,Kosuke C, AU - Shirotsuki,Kentaro, AU - Mikami,Ikuyo, AU - Hirata,Kanako, AU - Nagano,Yuichiro, AU - Nomura,Shinobu, AU - Shimada,Hironori, Y1 - 2012/01/16/ PY - 2011/10/12/received PY - 2011/12/21/revised PY - 2012/01/04/accepted PY - 2012/1/19/entrez PY - 2012/1/19/pubmed PY - 2013/2/5/medline SP - 39 EP - 44 JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology JO - Int J Psychophysiol VL - 84 IS - 1 N2 - OBJECTIVE: In this study, we investigated levels and relative ratios of adrenal hormones (including cortisol, dehydroepiandrosterone [DHEA], and DHEA-sulfate [DHEA-S]) and their psychophysiological correlates under acute psychosocial stress in individuals with irritable bowel syndrome (IBS). METHODS: Fifty-three college students participated in the study (male: 42, female: 11; mean age: 22.64years), including 13 individuals with IBS (IBS group) and 40 individuals without IBS (control group). The participants were exposed to a standardized laboratory stressor, which included delivering a speech and performing a mental arithmetic task. We measured subjective stress levels and salivary cortisol, DHEA, and DHEA-S levels at relevant time points before, during, and after the tasks. RESULTS: DHEA-S level and the DHEA-S/DHEA ratio in the IBS group were significantly lower than those in the control group, and the cortisol/DHEA-S ratio in the IBS group was higher than that in the control group throughout the experiment. In the IBS group, the appraisal of a threat was positively correlated with cortisol levels (r=0.61), and the appraisal of controllability was negatively correlated with cortisol levels (r=-0.64) and with the cortisol/DHEA ratio (r=-0.71). The control group showed a significant positive correlation between the appraisal of threat and cortisol levels (r=0.32). CONCLUSION: The present study indicates that individuals with IBS had lower DHEA-S levels, and that their stressful cognitive appraisals under acute psychosocial stress caused the effects of cortisol to dominate. This adrenal hormone response may be involved in exacerbating abdominal symptoms in individuals with IBS. SN - 1872-7697 UR - https://www.unboundmedicine.com/medline/citation/22251450/Adrenal_hormone_response_and_psychophysiological_correlates_under_psychosocial_stress_in_individuals_with_irritable_bowel_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-8760(12)00008-6 DB - PRIME DP - Unbound Medicine ER -