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Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes.
J Diabetes. 2012 Sep; 4(3):248-56.JD

Abstract

OBJECTIVES

The aim of the present study was to evaluate the antioxidant potential of embelin in streptozotocin-induced diabetes.

METHODS

Diabetes was induced in rats fasted overnight by the administration of a single dose of streptozotocin, and analyzed for blood, serum, and biological and histological pancreatic tissue parameters in intact control, diabetic, and embelin-treated diabetic rats (n = 9) at the dose levels of 15, 25, and 30 mg/kg/day for 21 days.

RESULTS

Diabetes caused highly significant abnormalities in blood, serum, and pancreatic tissue biochemical parameters. Embelin and glibenclamide administration to diabetic rats caused a highly significant decline in the blood glycated hemoglobin and serum glucose levels and nitric oxide activity, with a concomitant increase in the serum insulin level (P < 0.001). Furthermore, embelin and glibenclamide treatment increased the pancreatic antioxidant enzyme status (superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, glutathione S-transferase, and ascorbic acid), and also decreased the thiobarbituric acid reactive oxygen species contents (P < 0.001). The histoarchitecture of the diabetic rats typically showed a degenerated pancreas with reduced β-cell counts, while embelin treatment was shown to significantly regenerate islet cells.

CONCLUSION

The study proves the potent antioxidant activity of embelin, which has been found to be effective in managing severe hyperglycemia.

Authors+Show Affiliations

Department of Zoology, University of Rajasthan, Jaipur, India. rajnish_gupta1985@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22252046

Citation

Gupta, Rajnish, et al. "Antioxidant Activity and Protection of Pancreatic Β-cells By Embelin in Streptozotocin-induced Diabetes." Journal of Diabetes, vol. 4, no. 3, 2012, pp. 248-56.
Gupta R, Sharma AK, Sharma MC, et al. Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes. J Diabetes. 2012;4(3):248-56.
Gupta, R., Sharma, A. K., Sharma, M. C., & Gupta, R. S. (2012). Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes. Journal of Diabetes, 4(3), 248-56. https://doi.org/10.1111/j.1753-0407.2012.00187.x
Gupta R, et al. Antioxidant Activity and Protection of Pancreatic Β-cells By Embelin in Streptozotocin-induced Diabetes. J Diabetes. 2012;4(3):248-56. PubMed PMID: 22252046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes. AU - Gupta,Rajnish, AU - Sharma,Anil K, AU - Sharma,Mahesh C, AU - Gupta,Radhey S, PY - 2012/1/19/entrez PY - 2012/1/19/pubmed PY - 2013/2/5/medline SP - 248 EP - 56 JF - Journal of diabetes JO - J Diabetes VL - 4 IS - 3 N2 - OBJECTIVES: The aim of the present study was to evaluate the antioxidant potential of embelin in streptozotocin-induced diabetes. METHODS: Diabetes was induced in rats fasted overnight by the administration of a single dose of streptozotocin, and analyzed for blood, serum, and biological and histological pancreatic tissue parameters in intact control, diabetic, and embelin-treated diabetic rats (n = 9) at the dose levels of 15, 25, and 30 mg/kg/day for 21 days. RESULTS: Diabetes caused highly significant abnormalities in blood, serum, and pancreatic tissue biochemical parameters. Embelin and glibenclamide administration to diabetic rats caused a highly significant decline in the blood glycated hemoglobin and serum glucose levels and nitric oxide activity, with a concomitant increase in the serum insulin level (P < 0.001). Furthermore, embelin and glibenclamide treatment increased the pancreatic antioxidant enzyme status (superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, glutathione S-transferase, and ascorbic acid), and also decreased the thiobarbituric acid reactive oxygen species contents (P < 0.001). The histoarchitecture of the diabetic rats typically showed a degenerated pancreas with reduced β-cell counts, while embelin treatment was shown to significantly regenerate islet cells. CONCLUSION: The study proves the potent antioxidant activity of embelin, which has been found to be effective in managing severe hyperglycemia. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/22252046/Antioxidant_activity_and_protection_of_pancreatic_β_cells_by_embelin_in_streptozotocin_induced_diabetes_ L2 - https://doi.org/10.1111/j.1753-0407.2012.00187.x DB - PRIME DP - Unbound Medicine ER -