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Newer knowledge of vitamin D and its metabolites in health and disease.
Clin Orthop Relat Res 1979 Mar-Apr; (139):206-31CO

Abstract

Renewed interest in vitamin D, over the past several years, has resulted in increased knowledge of (1) the metabolic pathways which result in production of an active metabolite, (2) the role of its various metabolities at target tissues, and (3) its interaction with other control systems in the maintenance of calcium/phosphorus homeostasis. Presently, a role for 1, 25-(OH)2 D3 can be identified in the regulation of (1) calcium and phosphorus absorption from the intestine, (2) PTH production, and (3) calcium mobilization from bone (in conjunction with PTH). Several other actions at the kidney, muscle and other organs have been suggested but not proven. In contrast, the actual process of bone mineralization may be dependent, in part, on 25-(OH) D3. Despite these major advances in our knowledge, many gaps remain and controversial data continues unresolved. However, application of this new information to analysis of a wide variety of disease states has resulted in remarkable progress in appreciation of the pathogenesis and appropriate treatment for these diseases. Nonetheless, continued research promises further advances and more precise definition of disease states as well as delineation of the therapeutic role of Vitamin D metabolites in their treatment.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

222525

Citation

Drezner, M K., and J M. Harrelson. "Newer Knowledge of Vitamin D and Its Metabolites in Health and Disease." Clinical Orthopaedics and Related Research, 1979, pp. 206-31.
Drezner MK, Harrelson JM. Newer knowledge of vitamin D and its metabolites in health and disease. Clin Orthop Relat Res. 1979.
Drezner, M. K., & Harrelson, J. M. (1979). Newer knowledge of vitamin D and its metabolites in health and disease. Clinical Orthopaedics and Related Research, (139), pp. 206-31.
Drezner MK, Harrelson JM. Newer Knowledge of Vitamin D and Its Metabolites in Health and Disease. Clin Orthop Relat Res. 1979;(139)206-31. PubMed PMID: 222525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Newer knowledge of vitamin D and its metabolites in health and disease. AU - Drezner,M K, AU - Harrelson,J M, PY - 1979/3/1/pubmed PY - 1979/3/1/medline PY - 1979/3/1/entrez SP - 206 EP - 31 JF - Clinical orthopaedics and related research JO - Clin. Orthop. Relat. Res. IS - 139 N2 - Renewed interest in vitamin D, over the past several years, has resulted in increased knowledge of (1) the metabolic pathways which result in production of an active metabolite, (2) the role of its various metabolities at target tissues, and (3) its interaction with other control systems in the maintenance of calcium/phosphorus homeostasis. Presently, a role for 1, 25-(OH)2 D3 can be identified in the regulation of (1) calcium and phosphorus absorption from the intestine, (2) PTH production, and (3) calcium mobilization from bone (in conjunction with PTH). Several other actions at the kidney, muscle and other organs have been suggested but not proven. In contrast, the actual process of bone mineralization may be dependent, in part, on 25-(OH) D3. Despite these major advances in our knowledge, many gaps remain and controversial data continues unresolved. However, application of this new information to analysis of a wide variety of disease states has resulted in remarkable progress in appreciation of the pathogenesis and appropriate treatment for these diseases. Nonetheless, continued research promises further advances and more precise definition of disease states as well as delineation of the therapeutic role of Vitamin D metabolites in their treatment. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/222525/Newer_knowledge_of_vitamin_D_and_its_metabolites_in_health_and_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=222525.ui DB - PRIME DP - Unbound Medicine ER -