Tags

Type your tag names separated by a space and hit enter

Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity.
Nutrients. 2010 10; 2(10):1048-59.N

Abstract

It has been suggested that the dietary intake of antioxidant supplements could be a useful strategy to reduce the incidence of diseases associated with oxidative stress. The aim of present work is to study the possibility to obtain compounds with antioxidant activity from wine wastes using water as solvent. Results have shown that it is possible to obtain flavan-3-ol compounds from wine wastes both from V. vinifera (cv. Cabernet Sauvignon and Merlot) and V. labrusca (cv. Bordo and Isabella) species. The main phenolic compounds found in the extracts were catechin and epicatechin, followed by procyanidin B3, procyanidin B1, procyanidin B2, gallic acid, epigallocatechin, and procyanidin B4. All flavan-3-ol extracts showed significant in vitro and in vivo activities. It was found that the extracts were able to prevent lipid and protein oxidative damage in the cerebral cortex, cerebellum and hippocampus tissues of rats. Although further studies are necessary, these flavan-3-ol extracts show potential to be used to reduce the incidence of degenerative diseases associated with oxidative stress.

Authors+Show Affiliations

Instituto de Biotecnologia, Universidade de Caxias do Sul, 95070560 Caxias do Sul, RS, Brazil. gustavo.scola@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22253995

Citation

Scola, Gustavo, et al. "Flavan-3-ol Compounds From Wine Wastes With in Vitro and in Vivo Antioxidant Activity." Nutrients, vol. 2, no. 10, 2010, pp. 1048-59.
Scola G, Conte D, Spada PW, et al. Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity. Nutrients. 2010;2(10):1048-59.
Scola, G., Conte, D., Spada, P. W., Dani, C., Vanderlinde, R., Funchal, C., & Salvador, M. (2010). Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity. Nutrients, 2(10), 1048-59. https://doi.org/10.3390/nu2101048
Scola G, et al. Flavan-3-ol Compounds From Wine Wastes With in Vitro and in Vivo Antioxidant Activity. Nutrients. 2010;2(10):1048-59. PubMed PMID: 22253995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity. AU - Scola,Gustavo, AU - Conte,Danusa, AU - Spada,Patrícia Wilmsen Dalla-Santa, AU - Dani,Caroline, AU - Vanderlinde,Regina, AU - Funchal,Claudia, AU - Salvador,Mirian, Y1 - 2010/10/11/ PY - 2010/09/08/received PY - 2010/09/28/revised PY - 2010/09/30/accepted PY - 2012/1/19/entrez PY - 2010/10/1/pubmed PY - 2012/4/10/medline KW - V. labrusca KW - V. vinifera KW - antioxidant KW - aqueous wine waste extracts KW - phenolic content SP - 1048 EP - 59 JF - Nutrients JO - Nutrients VL - 2 IS - 10 N2 - It has been suggested that the dietary intake of antioxidant supplements could be a useful strategy to reduce the incidence of diseases associated with oxidative stress. The aim of present work is to study the possibility to obtain compounds with antioxidant activity from wine wastes using water as solvent. Results have shown that it is possible to obtain flavan-3-ol compounds from wine wastes both from V. vinifera (cv. Cabernet Sauvignon and Merlot) and V. labrusca (cv. Bordo and Isabella) species. The main phenolic compounds found in the extracts were catechin and epicatechin, followed by procyanidin B3, procyanidin B1, procyanidin B2, gallic acid, epigallocatechin, and procyanidin B4. All flavan-3-ol extracts showed significant in vitro and in vivo activities. It was found that the extracts were able to prevent lipid and protein oxidative damage in the cerebral cortex, cerebellum and hippocampus tissues of rats. Although further studies are necessary, these flavan-3-ol extracts show potential to be used to reduce the incidence of degenerative diseases associated with oxidative stress. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/22253995/Flavan_3_ol_compounds_from_wine_wastes_with_in_vitro_and_in_vivo_antioxidant_activity_ L2 - https://www.mdpi.com/resolver?pii=nu2101048 DB - PRIME DP - Unbound Medicine ER -