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Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day.
Nutrients. 2011 Jan; 3(1):49-62.N

Abstract

Primary prevention of most folate-responsive neural tube defects (NTDs) may not require 400 μg folic acid/day but may be achieved by attaining a high maternal folate status. Using RBC folate ≥906 nmol/L as a marker for NTD risk reduction, the study aimed to determine the change in blood folate concentrations in reproductive age women in response to long-term folic acid supplementation at 400 µg/day and 140 µg/day (dose designed to mimic the average daily folic acid intake received from New Zealand's proposed mandatory bread fortification program). Participants were randomly assigned to a daily folic acid supplement of 140 µg (n = 49), 400 µg (n = 48) or placebo (n = 47) for 40 weeks. RBC folate concentrations were measured at baseline, and after 6, 12, 29 and 40 weeks. At 40 weeks, the overall prevalence of having a RBC folate <906 nmol/L decreased to 18% and 35% in the 400 µg and 140 µg groups, respectively, while remaining relatively unchanged at 58% in the placebo group. After 40 weeks, there was no evidence of a difference in RBC folate between the two treatment groups (P = 0.340), nor was there evidence of a difference in the odds of a RBC folate <906 nmol/L (P = 0.078). In conclusion, the average daily intake of folic acid received from the proposed fortification program would increase RBC folate concentrations in reproductive age women to levels associated with a low risk of NTDs.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand. hurni473@student.otago.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22254076

Citation

Hursthouse, Nicola A., et al. "Folate Status of Reproductive Age Women and Neural Tube Defect Risk: the Effect of Long-term Folic Acid Supplementation at Doses of 140 Μg and 400 Μg Per Day." Nutrients, vol. 3, no. 1, 2011, pp. 49-62.
Hursthouse NA, Gray AR, Miller JC, et al. Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day. Nutrients. 2011;3(1):49-62.
Hursthouse, N. A., Gray, A. R., Miller, J. C., Rose, M. C., & Houghton, L. A. (2011). Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day. Nutrients, 3(1), 49-62. https://doi.org/10.3390/nu3010049
Hursthouse NA, et al. Folate Status of Reproductive Age Women and Neural Tube Defect Risk: the Effect of Long-term Folic Acid Supplementation at Doses of 140 Μg and 400 Μg Per Day. Nutrients. 2011;3(1):49-62. PubMed PMID: 22254076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day. AU - Hursthouse,Nicola A, AU - Gray,Andrew R, AU - Miller,Jody C, AU - Rose,Meredith C, AU - Houghton,Lisa A, Y1 - 2011/01/10/ PY - 2010/11/22/received PY - 2010/12/13/revised PY - 2011/01/07/accepted PY - 2012/1/19/entrez PY - 2012/1/19/pubmed PY - 2012/5/1/medline KW - neural tube defects KW - blood folate status KW - folic acid fortification KW - supplementation SP - 49 EP - 62 JF - Nutrients JO - Nutrients VL - 3 IS - 1 N2 - Primary prevention of most folate-responsive neural tube defects (NTDs) may not require 400 μg folic acid/day but may be achieved by attaining a high maternal folate status. Using RBC folate ≥906 nmol/L as a marker for NTD risk reduction, the study aimed to determine the change in blood folate concentrations in reproductive age women in response to long-term folic acid supplementation at 400 µg/day and 140 µg/day (dose designed to mimic the average daily folic acid intake received from New Zealand's proposed mandatory bread fortification program). Participants were randomly assigned to a daily folic acid supplement of 140 µg (n = 49), 400 µg (n = 48) or placebo (n = 47) for 40 weeks. RBC folate concentrations were measured at baseline, and after 6, 12, 29 and 40 weeks. At 40 weeks, the overall prevalence of having a RBC folate <906 nmol/L decreased to 18% and 35% in the 400 µg and 140 µg groups, respectively, while remaining relatively unchanged at 58% in the placebo group. After 40 weeks, there was no evidence of a difference in RBC folate between the two treatment groups (P = 0.340), nor was there evidence of a difference in the odds of a RBC folate <906 nmol/L (P = 0.078). In conclusion, the average daily intake of folic acid received from the proposed fortification program would increase RBC folate concentrations in reproductive age women to levels associated with a low risk of NTDs. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/22254076/Folate_status_of_reproductive_age_women_and_neural_tube_defect_risk:_the_effect_of_long_term_folic_acid_supplementation_at_doses_of_140_µg_and_400_µg_per_day_ L2 - https://www.mdpi.com/resolver?pii=nutrients-03-00049 DB - PRIME DP - Unbound Medicine ER -