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Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications.
J Psychiatr Res 2012; 46(4):451-5JP

Abstract

Adult Attention Deficit Hyperactivity Disorder (A-ADHD) is one of the psychiatric disorders which awareness is growing. The exact causes of A-ADHD are still unknown. In addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in its etiology. In our study, we aimed to evaluate the oxidative status of A-ADHD patients and investigate whether oxidative metabolites can be used as diagnostic tools or not in A-ADHD. Blood samples were taken from enrolled 50 A-ADHD patients and 31 controls in appropriate way and Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups and ROC curve was drawn in order to evaluate diagnostic performances. Patients' TAS, TOS and OSI were significantly higher than controls. There was not a significant difference between comorbid cases and only A-ADHD patients in terms of measured values. A-ADHD can be predicted for TOS over 9.8575 μmol H(2)O(2) Eqv./L level with 86% positive predictive value and %100 negative predictive value. In A-ADHD, oxidative balance is impaired. High antioxidant levels may be compensatory against the oxidant increase. Oxidative parameters may be used in A-ADHD diagnosis.

Authors+Show Affiliations

Harran University, Faculty of Medicine, Psychiatry Dept., Yenisehir Kampus, 63300 Sanliurfa, Turkey. drselek@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22257388

Citation

Selek, Salih, et al. "Evaluation of Total Oxidative Status in Adult Attention Deficit Hyperactivity Disorder and Its Diagnostic Implications." Journal of Psychiatric Research, vol. 46, no. 4, 2012, pp. 451-5.
Selek S, Bulut M, Ocak AR, et al. Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications. J Psychiatr Res. 2012;46(4):451-5.
Selek, S., Bulut, M., Ocak, A. R., Kalenderoğlu, A., & Savaş, H. A. (2012). Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications. Journal of Psychiatric Research, 46(4), pp. 451-5. doi:10.1016/j.jpsychires.2011.12.007.
Selek S, et al. Evaluation of Total Oxidative Status in Adult Attention Deficit Hyperactivity Disorder and Its Diagnostic Implications. J Psychiatr Res. 2012;46(4):451-5. PubMed PMID: 22257388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications. AU - Selek,Salih, AU - Bulut,Mahmut, AU - Ocak,Ali Rıza, AU - Kalenderoğlu,Aysun, AU - Savaş,Haluk A, Y1 - 2012/01/17/ PY - 2011/08/02/received PY - 2011/12/20/revised PY - 2011/12/23/accepted PY - 2012/1/20/entrez PY - 2012/1/20/pubmed PY - 2012/7/21/medline SP - 451 EP - 5 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 46 IS - 4 N2 - Adult Attention Deficit Hyperactivity Disorder (A-ADHD) is one of the psychiatric disorders which awareness is growing. The exact causes of A-ADHD are still unknown. In addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in its etiology. In our study, we aimed to evaluate the oxidative status of A-ADHD patients and investigate whether oxidative metabolites can be used as diagnostic tools or not in A-ADHD. Blood samples were taken from enrolled 50 A-ADHD patients and 31 controls in appropriate way and Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups and ROC curve was drawn in order to evaluate diagnostic performances. Patients' TAS, TOS and OSI were significantly higher than controls. There was not a significant difference between comorbid cases and only A-ADHD patients in terms of measured values. A-ADHD can be predicted for TOS over 9.8575 μmol H(2)O(2) Eqv./L level with 86% positive predictive value and %100 negative predictive value. In A-ADHD, oxidative balance is impaired. High antioxidant levels may be compensatory against the oxidant increase. Oxidative parameters may be used in A-ADHD diagnosis. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/22257388/Evaluation_of_total_oxidative_status_in_adult_attention_deficit_hyperactivity_disorder_and_its_diagnostic_implications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(11)00289-5 DB - PRIME DP - Unbound Medicine ER -