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[Interactions of insulin and estrogen in the regulation of cell proliferation and carcinogenesis].
Orv Hetil. 2012 Jan 29; 153(4):125-36.OH

Abstract

Equilibrium of sexual steroids and metabolic processes has close correlations. Insulin is a potent regulator of human sexual steroid hormone production and modulates their signals at receptor level. Insulin resistance and excessive insulin production provoke hyperandrogenism and estrogen deficiency in women resulting not only in anovulatory dysfunction but also a high risk for cardiovascular diseases and cancer. Physiologic functions of all female organs have higher estrogen demand as compared with men. In healthy women estrogen predominance against androgens is a favor in their reproductive period, which means a strong defense against insulin resistance and its complications. However, in postmenopausal cases the increasing prevalence of insulin resistance and type-2 diabetes associated with estrogen deficiency and androgen excess, result in a gender specific higher risk for precancerous lesions and cancer as compared with men. Estrogen has beneficial effect on the energy metabolism, glucose homeostasis and on the lipid metabolism of liver and of peripheral tissues as well. A moderate or severe decrease in serum estrogen level enhances the prevalence of insulin resistant states. In premenopausal women long or irregular menstrual cycles are predictors for the risk of insulin resistance and type-2 diabetes. Moreover, in postmenopausal estrogen deficient cases elevated fasting glucose, increased body weight and abdominal fat deposition are often observed progressively with age in correlation with an impaired glucose tolerance. In the rare cases of estrogen deficient men severe type-2 diabetes seems to be a characteristic complication. Upon becoming familiar with the cancer risk of insulin resistance and estrogen deficiency, there would be plenty of possibilities for primary cancer prevention. In patients with cancer the treatment of hormonal and metabolic disturbances may become effective adjuvant therapy.

Authors+Show Affiliations

Országos Onkológiai Intézet Sebészeti és Molekuláris Tumorpatológiai Osztály Budapest Ráth György u. subazdr@gmail.comNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

hun

PubMed ID

22257509

Citation

Suba, Zsuzsanna, and Miklós Kásler. "[Interactions of Insulin and Estrogen in the Regulation of Cell Proliferation and Carcinogenesis]." Orvosi Hetilap, vol. 153, no. 4, 2012, pp. 125-36.
Suba Z, Kásler M. [Interactions of insulin and estrogen in the regulation of cell proliferation and carcinogenesis]. Orv Hetil. 2012;153(4):125-36.
Suba, Z., & Kásler, M. (2012). [Interactions of insulin and estrogen in the regulation of cell proliferation and carcinogenesis]. Orvosi Hetilap, 153(4), 125-36. https://doi.org/10.1556/OH.2012.29287
Suba Z, Kásler M. [Interactions of Insulin and Estrogen in the Regulation of Cell Proliferation and Carcinogenesis]. Orv Hetil. 2012 Jan 29;153(4):125-36. PubMed PMID: 22257509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Interactions of insulin and estrogen in the regulation of cell proliferation and carcinogenesis]. AU - Suba,Zsuzsanna, AU - Kásler,Miklós, PY - 2012/1/20/entrez PY - 2012/1/20/pubmed PY - 2012/3/1/medline SP - 125 EP - 36 JF - Orvosi hetilap JO - Orv Hetil VL - 153 IS - 4 N2 - Equilibrium of sexual steroids and metabolic processes has close correlations. Insulin is a potent regulator of human sexual steroid hormone production and modulates their signals at receptor level. Insulin resistance and excessive insulin production provoke hyperandrogenism and estrogen deficiency in women resulting not only in anovulatory dysfunction but also a high risk for cardiovascular diseases and cancer. Physiologic functions of all female organs have higher estrogen demand as compared with men. In healthy women estrogen predominance against androgens is a favor in their reproductive period, which means a strong defense against insulin resistance and its complications. However, in postmenopausal cases the increasing prevalence of insulin resistance and type-2 diabetes associated with estrogen deficiency and androgen excess, result in a gender specific higher risk for precancerous lesions and cancer as compared with men. Estrogen has beneficial effect on the energy metabolism, glucose homeostasis and on the lipid metabolism of liver and of peripheral tissues as well. A moderate or severe decrease in serum estrogen level enhances the prevalence of insulin resistant states. In premenopausal women long or irregular menstrual cycles are predictors for the risk of insulin resistance and type-2 diabetes. Moreover, in postmenopausal estrogen deficient cases elevated fasting glucose, increased body weight and abdominal fat deposition are often observed progressively with age in correlation with an impaired glucose tolerance. In the rare cases of estrogen deficient men severe type-2 diabetes seems to be a characteristic complication. Upon becoming familiar with the cancer risk of insulin resistance and estrogen deficiency, there would be plenty of possibilities for primary cancer prevention. In patients with cancer the treatment of hormonal and metabolic disturbances may become effective adjuvant therapy. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/22257509/[Interactions_of_insulin_and_estrogen_in_the_regulation_of_cell_proliferation_and_carcinogenesis]_ L2 - http://www.akademiai.com/doi/full/10.1556/OH.2012.29287?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -