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APOL1 and kidney disease.
Curr Opin Nephrol Hypertens 2012; 21(2):179-82CO

Abstract

PURPOSE OF REVIEW

We review recent work on the genetic basis of kidney disease in African Americans and its relationship to variation in the APOL1 gene.

RECENT FINDINGS

People of recent African ancestry develop kidney disease at rates 4-5 times higher than most other groups. This observation holds for kidney disease attributed to hypertension, as well as focal segmental glomerulosclerosis (FSGS), and HIV-associated nephropathy (HIVAN). Recent work suggests that the high risk for all of these forms of kidney disease in African Americans is conferred by the same genetic risk factors, specifically two coding sequence variants in the APOL1 gene.

SUMMARY

Future studies aimed at understanding the clinical implications of APOL1 genotype in the setting of HIV infection, proteinuria, and hypertension-associated kidney disease will help clarify how these recent findings should influence a nephrologist's decisions about patient care. Studies exploring the cellular and molecular mechanisms of APOL1-associated disease may lead to new methods of treatment.

Authors+Show Affiliations

Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. mpollak@bidmc.harvard.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22257798

Citation

Pollak, Martin R., et al. "APOL1 and Kidney Disease." Current Opinion in Nephrology and Hypertension, vol. 21, no. 2, 2012, pp. 179-82.
Pollak MR, Genovese G, Friedman DJ. APOL1 and kidney disease. Curr Opin Nephrol Hypertens. 2012;21(2):179-82.
Pollak, M. R., Genovese, G., & Friedman, D. J. (2012). APOL1 and kidney disease. Current Opinion in Nephrology and Hypertension, 21(2), pp. 179-82. doi:10.1097/MNH.0b013e32835012ab.
Pollak MR, Genovese G, Friedman DJ. APOL1 and Kidney Disease. Curr Opin Nephrol Hypertens. 2012;21(2):179-82. PubMed PMID: 22257798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - APOL1 and kidney disease. AU - Pollak,Martin R, AU - Genovese,Giulio, AU - Friedman,David J, PY - 2012/1/20/entrez PY - 2012/1/20/pubmed PY - 2012/6/5/medline SP - 179 EP - 82 JF - Current opinion in nephrology and hypertension JO - Curr. Opin. Nephrol. Hypertens. VL - 21 IS - 2 N2 - PURPOSE OF REVIEW: We review recent work on the genetic basis of kidney disease in African Americans and its relationship to variation in the APOL1 gene. RECENT FINDINGS: People of recent African ancestry develop kidney disease at rates 4-5 times higher than most other groups. This observation holds for kidney disease attributed to hypertension, as well as focal segmental glomerulosclerosis (FSGS), and HIV-associated nephropathy (HIVAN). Recent work suggests that the high risk for all of these forms of kidney disease in African Americans is conferred by the same genetic risk factors, specifically two coding sequence variants in the APOL1 gene. SUMMARY: Future studies aimed at understanding the clinical implications of APOL1 genotype in the setting of HIV infection, proteinuria, and hypertension-associated kidney disease will help clarify how these recent findings should influence a nephrologist's decisions about patient care. Studies exploring the cellular and molecular mechanisms of APOL1-associated disease may lead to new methods of treatment. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/22257798/APOL1_and_kidney_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=22257798 DB - PRIME DP - Unbound Medicine ER -