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Necrotizing periodontal diseases in HIV-infected Brazilian patients: a clinical and microbiologic descriptive study.
Quintessence Int. 2012 Jan; 43(1):71-82.QI

Abstract

OBJECTIVE

Nowadays, necrotizing periodontal diseases have a low prevalence; however, a better understanding of the etiopathogenesis of these diseases is necessary for determining more adequate preventive and therapeutic strategies.

METHOD AND MATERIALS

From a pool of 1,232 HIV-infected patients, 15 presented with necrotizing periodontal diseases, which were evaluated by full-mouth periodontal clinical measurements. Subgingival biofilm samples were collected from necrotizing lesions of six of these individuals. The presence and levels of 47 bacterial species were determined by checkerboard DNA-DNA hybridization.

RESULTS

All 15 patients (10 had severe immunodeficiency) had been infected sexually. Thirteen patients were taking antiretroviral medication (66.7% undergoing highly active antiretroviral therapy). Regarding necrotizing periodontal diseases, necrotizing ulcerative gingivitis (60%) was more prevalent than necrotizing ulcerative periodontitis (40%). The frequency of supragingival biofilm and bleeding on probing ranged from 11.5% to 59.2% and 3.0% to 54.0%, respectively, whereas the mean probing depth and clinical attachment level were between 1.48 and 2.61 mm and 1.30 and 2.62 mm, respectively. Species detected in high prevalence and/or counts in necrotizing lesions included Treponema denticola, Eikenella corrodens, Dialister pneumosintes, Enterococcus faecalis, Streptococcus intermedius, Aggregatibacter actinomycetemcomitans, and Campylobacter rectus. In contrast, Parvimonas micra, Prevotella melaninogenica, Fusobacterium nucleatum, Eubacterium nodatum, and Helicobacter pylori were observed in the lowest mean prevalence and/or counts.

CONCLUSION

Necrotizing periodontal disease lesions in HIV-infected patients present a microbiota with high prevalence and/or counts of classical periodontal pathogens, in particular T denticola, as well as species not commonly considered as periodontal pathogens, such as E faecalis and D pneumosintes. In addition, these individuals with necrotizing periodontal disease frequently display severe immunodeficiency and AIDS-defining diseases such as tuberculosis.

Authors+Show Affiliations

Department of Periodontology, Brazilian Navy, Rio de Janeiro, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22259811

Citation

Ramos, Meyrelane Pereira de Almeida, et al. "Necrotizing Periodontal Diseases in HIV-infected Brazilian Patients: a Clinical and Microbiologic Descriptive Study." Quintessence International (Berlin, Germany : 1985), vol. 43, no. 1, 2012, pp. 71-82.
Ramos MP, Ferreira SM, Silva-Boghossian CM, et al. Necrotizing periodontal diseases in HIV-infected Brazilian patients: a clinical and microbiologic descriptive study. Quintessence Int. 2012;43(1):71-82.
Ramos, M. P., Ferreira, S. M., Silva-Boghossian, C. M., Souto, R., Colombo, A. P., Noce, C. W., & Gonçalves, L. S. (2012). Necrotizing periodontal diseases in HIV-infected Brazilian patients: a clinical and microbiologic descriptive study. Quintessence International (Berlin, Germany : 1985), 43(1), 71-82.
Ramos MP, et al. Necrotizing Periodontal Diseases in HIV-infected Brazilian Patients: a Clinical and Microbiologic Descriptive Study. Quintessence Int. 2012;43(1):71-82. PubMed PMID: 22259811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrotizing periodontal diseases in HIV-infected Brazilian patients: a clinical and microbiologic descriptive study. AU - Ramos,Meyrelane Pereira de Almeida, AU - Ferreira,Sonia Maria Soares, AU - Silva-Boghossian,Carina M, AU - Souto,Renata, AU - Colombo,Ana Paula, AU - Noce,Cesar Werneck, AU - Gonçalves,Lucio de Souza, PY - 2012/1/20/entrez PY - 2012/1/20/pubmed PY - 2012/6/12/medline SP - 71 EP - 82 JF - Quintessence international (Berlin, Germany : 1985) JO - Quintessence Int VL - 43 IS - 1 N2 - OBJECTIVE: Nowadays, necrotizing periodontal diseases have a low prevalence; however, a better understanding of the etiopathogenesis of these diseases is necessary for determining more adequate preventive and therapeutic strategies. METHOD AND MATERIALS: From a pool of 1,232 HIV-infected patients, 15 presented with necrotizing periodontal diseases, which were evaluated by full-mouth periodontal clinical measurements. Subgingival biofilm samples were collected from necrotizing lesions of six of these individuals. The presence and levels of 47 bacterial species were determined by checkerboard DNA-DNA hybridization. RESULTS: All 15 patients (10 had severe immunodeficiency) had been infected sexually. Thirteen patients were taking antiretroviral medication (66.7% undergoing highly active antiretroviral therapy). Regarding necrotizing periodontal diseases, necrotizing ulcerative gingivitis (60%) was more prevalent than necrotizing ulcerative periodontitis (40%). The frequency of supragingival biofilm and bleeding on probing ranged from 11.5% to 59.2% and 3.0% to 54.0%, respectively, whereas the mean probing depth and clinical attachment level were between 1.48 and 2.61 mm and 1.30 and 2.62 mm, respectively. Species detected in high prevalence and/or counts in necrotizing lesions included Treponema denticola, Eikenella corrodens, Dialister pneumosintes, Enterococcus faecalis, Streptococcus intermedius, Aggregatibacter actinomycetemcomitans, and Campylobacter rectus. In contrast, Parvimonas micra, Prevotella melaninogenica, Fusobacterium nucleatum, Eubacterium nodatum, and Helicobacter pylori were observed in the lowest mean prevalence and/or counts. CONCLUSION: Necrotizing periodontal disease lesions in HIV-infected patients present a microbiota with high prevalence and/or counts of classical periodontal pathogens, in particular T denticola, as well as species not commonly considered as periodontal pathogens, such as E faecalis and D pneumosintes. In addition, these individuals with necrotizing periodontal disease frequently display severe immunodeficiency and AIDS-defining diseases such as tuberculosis. SN - 1936-7163 UR - https://www.unboundmedicine.com/medline/citation/22259811/Necrotizing_periodontal_diseases_in_HIV_infected_Brazilian_patients:_a_clinical_and_microbiologic_descriptive_study_ L2 - https://qi.quintessenz.de/index.php?doc=abstract&abstractID=22496/ DB - PRIME DP - Unbound Medicine ER -