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CTRP family: linking immunity to metabolism.
Trends Endocrinol Metab. 2012 Apr; 23(4):194-204.TE

Abstract

It is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic diseases such as visceral obesity and type 2 diabetes are characterized by high levels of proinflammatory cytokines. Metabolism and immunity are linked by proteins of dual function. Adiponectin, a member of the C1q/TNF-related protein (CTRP) family, has attracted much interest because of its anti-inflammatory and insulin-sensitizing effects. To date, 15 additional CTRP family members have been identified that might also play a role in metabolism and immunity. This review focuses on the biochemistry and pleiotropic physiological functions of CTRPs as new molecular mediators connecting inflammatory and metabolic diseases.

Authors+Show Affiliations

Department of Internal Medicine I, Regensburg University Medical Center, D-93042 Regensburg, Germany. andreas.schaeffler@klinik.uni-regensburg.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22261190

Citation

Schäffler, Andreas, and Christa Buechler. "CTRP Family: Linking Immunity to Metabolism." Trends in Endocrinology and Metabolism: TEM, vol. 23, no. 4, 2012, pp. 194-204.
Schäffler A, Buechler C. CTRP family: linking immunity to metabolism. Trends Endocrinol Metab. 2012;23(4):194-204.
Schäffler, A., & Buechler, C. (2012). CTRP family: linking immunity to metabolism. Trends in Endocrinology and Metabolism: TEM, 23(4), 194-204. https://doi.org/10.1016/j.tem.2011.12.003
Schäffler A, Buechler C. CTRP Family: Linking Immunity to Metabolism. Trends Endocrinol Metab. 2012;23(4):194-204. PubMed PMID: 22261190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CTRP family: linking immunity to metabolism. AU - Schäffler,Andreas, AU - Buechler,Christa, Y1 - 2012/01/17/ PY - 2011/08/16/received PY - 2011/12/09/revised PY - 2011/12/13/accepted PY - 2012/1/21/entrez PY - 2012/1/21/pubmed PY - 2012/7/21/medline SP - 194 EP - 204 JF - Trends in endocrinology and metabolism: TEM JO - Trends Endocrinol Metab VL - 23 IS - 4 N2 - It is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic diseases such as visceral obesity and type 2 diabetes are characterized by high levels of proinflammatory cytokines. Metabolism and immunity are linked by proteins of dual function. Adiponectin, a member of the C1q/TNF-related protein (CTRP) family, has attracted much interest because of its anti-inflammatory and insulin-sensitizing effects. To date, 15 additional CTRP family members have been identified that might also play a role in metabolism and immunity. This review focuses on the biochemistry and pleiotropic physiological functions of CTRPs as new molecular mediators connecting inflammatory and metabolic diseases. SN - 1879-3061 UR - https://www.unboundmedicine.com/medline/citation/22261190/CTRP_family:_linking_immunity_to_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-2760(11)00191-3 DB - PRIME DP - Unbound Medicine ER -