Tags

Type your tag names separated by a space and hit enter

Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats.
Thromb Res. 2012 Jul; 130(1):75-80.TR

Abstract

OBJECTIVE

This study was designed to investigate the possible antiplatelet effect of aqueous whole-plant C. aronia syn: Azarolus (L) extract using Wistar albino rats as a model.

MATERIALS AND METHODS

Forty-two male albino Wistar rats weighing 200 to 250 g were divided into seven groups with six rats in each group. Group 1 served as the control and received equal volumes of distilled water. Groups 2-6 served as the experimental groups and were given C. aronia extract at doses of 100, 200, 500, 1,000, and 2,000 mg/kg, while group 7 served as a positive control and was given aspirin (25mg/kg). All the doses were administered orally once a day and the treatment was continued for seven days. In all groups, at the end of the experimental procedure, blood samples were obtained for platelet function measurements, including PFA-100, thromboxane B2 levels, platelet count, and haematocrit. The bleeding time was determined using a modified tail cutting method described previously.

RESULTS

The aqueous C. aronia syn. Azarolus (L) extract significantly altered the bleeding time and the closure time, as determined by the PFA-100 and thromboxane B2 levels, suggesting significant platelet function inhibition. These effects were observed with C. aronia doses between 100 - 500 mg/kg, which yielded thromboxane B2 levels of 1,000 mg/kg, whereas the higher dose (2,000 mg/kg) produced opposite effects on these parameters.

CONCLUSION

C. aronia syn. Azarolus (L) aqueous extract has antiplatelet effects in Wistar albino rats.

Authors+Show Affiliations

Department of Cardiology, King Khalid University, Abha, Saudi Arabia. asshalghamdi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22261477

Citation

Shatoor, Abdullah S., et al. "Effect of Hawthorn (Crataegus Aronia Syn. Azarolus (L)) On Platelet Function in Albino Wistar Rats." Thrombosis Research, vol. 130, no. 1, 2012, pp. 75-80.
Shatoor AS, Soliman H, Al-Hashem F, et al. Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. Thromb Res. 2012;130(1):75-80.
Shatoor, A. S., Soliman, H., Al-Hashem, F., Gamal, B. E., Othman, A., & El-Menshawy, N. (2012). Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. Thrombosis Research, 130(1), 75-80. https://doi.org/10.1016/j.thromres.2012.01.001
Shatoor AS, et al. Effect of Hawthorn (Crataegus Aronia Syn. Azarolus (L)) On Platelet Function in Albino Wistar Rats. Thromb Res. 2012;130(1):75-80. PubMed PMID: 22261477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. AU - Shatoor,Abdullah S, AU - Soliman,Hesham, AU - Al-Hashem,Fahaid, AU - Gamal,Basiouny El-, AU - Othman,Adel, AU - El-Menshawy,Nadia, Y1 - 2012/01/17/ PY - 2011/08/23/received PY - 2011/12/30/revised PY - 2012/01/02/accepted PY - 2012/1/21/entrez PY - 2012/1/21/pubmed PY - 2012/10/2/medline SP - 75 EP - 80 JF - Thrombosis research JO - Thromb Res VL - 130 IS - 1 N2 - OBJECTIVE: This study was designed to investigate the possible antiplatelet effect of aqueous whole-plant C. aronia syn: Azarolus (L) extract using Wistar albino rats as a model. MATERIALS AND METHODS: Forty-two male albino Wistar rats weighing 200 to 250 g were divided into seven groups with six rats in each group. Group 1 served as the control and received equal volumes of distilled water. Groups 2-6 served as the experimental groups and were given C. aronia extract at doses of 100, 200, 500, 1,000, and 2,000 mg/kg, while group 7 served as a positive control and was given aspirin (25mg/kg). All the doses were administered orally once a day and the treatment was continued for seven days. In all groups, at the end of the experimental procedure, blood samples were obtained for platelet function measurements, including PFA-100, thromboxane B2 levels, platelet count, and haematocrit. The bleeding time was determined using a modified tail cutting method described previously. RESULTS: The aqueous C. aronia syn. Azarolus (L) extract significantly altered the bleeding time and the closure time, as determined by the PFA-100 and thromboxane B2 levels, suggesting significant platelet function inhibition. These effects were observed with C. aronia doses between 100 - 500 mg/kg, which yielded thromboxane B2 levels of 1,000 mg/kg, whereas the higher dose (2,000 mg/kg) produced opposite effects on these parameters. CONCLUSION: C. aronia syn. Azarolus (L) aqueous extract has antiplatelet effects in Wistar albino rats. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/22261477/Effect_of_Hawthorn__Crataegus_aronia_syn__Azarolus__L___on_platelet_function_in_albino_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(12)00005-9 DB - PRIME DP - Unbound Medicine ER -