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Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome.
J Perinatol 2012; 32(10):770-6JP

Abstract

OBJECTIVE

To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS).

STUDY DESIGN

Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women.

RESULT

Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P<0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal-placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not.

CONCLUSION

A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Kaiser Permanente Oakland Medical Center, Oakland, CA 94612, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22261835

Citation

Yamamoto, M, et al. "Risk of Preterm Delivery in Non-diabetic Women With Polycystic Ovarian Syndrome." Journal of Perinatology : Official Journal of the California Perinatal Association, vol. 32, no. 10, 2012, pp. 770-6.
Yamamoto M, Feigenbaum SL, Crites Y, et al. Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome. J Perinatol. 2012;32(10):770-6.
Yamamoto, M., Feigenbaum, S. L., Crites, Y., Escobar, G. J., Yang, J., Ferrara, A., & Lo, J. C. (2012). Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome. Journal of Perinatology : Official Journal of the California Perinatal Association, 32(10), pp. 770-6. doi:10.1038/jp.2011.194.
Yamamoto M, et al. Risk of Preterm Delivery in Non-diabetic Women With Polycystic Ovarian Syndrome. J Perinatol. 2012;32(10):770-6. PubMed PMID: 22261835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome. AU - Yamamoto,M, AU - Feigenbaum,S L, AU - Crites,Y, AU - Escobar,G J, AU - Yang,J, AU - Ferrara,A, AU - Lo,J C, Y1 - 2012/01/19/ PY - 2012/1/21/entrez PY - 2012/1/21/pubmed PY - 2013/4/4/medline SP - 770 EP - 6 JF - Journal of perinatology : official journal of the California Perinatal Association JO - J Perinatol VL - 32 IS - 10 N2 - OBJECTIVE: To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS). STUDY DESIGN: Retrospective cohort study comparing preterm delivery rate among non-diabetic PCOS and non-PCOS women with singleton pregnancy. Multivariable logistic regression was used to identify predictors of preterm delivery among PCOS women. RESULT: Among 908 PCOS women with singleton pregnancy, 12.9% delivered preterm compared with 7.4% among non-PCOS women (P<0.01). Causes of preterm delivery among PCOS women included preterm labor (41%), cervical insufficiency (11%), hypertensive complications (20%), preterm premature rupture of membranes (15%), fetal-placental concerns (9%) and intrauterine fetal demise (5%). Maternal age, race/ethnicity and nulliparity were significant predictors of preterm delivery in PCOS, whereas body mass index and fertility medications were not. CONCLUSION: A higher proportion of PCOS women delivered preterm (12.9%) compared with non-PCOS women, with the majority of cases due to spontaneous preterm birth. Future studies should explore etiologies and strategies to improve pregnancy outcomes in PCOS. SN - 1476-5543 UR - https://www.unboundmedicine.com/medline/citation/22261835/Risk_of_preterm_delivery_in_non_diabetic_women_with_polycystic_ovarian_syndrome_ L2 - http://dx.doi.org/10.1038/jp.2011.194 DB - PRIME DP - Unbound Medicine ER -