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Berry fruit enhances beneficial signaling in the brain.
J Agric Food Chem. 2012 Jun 13; 60(23):5709-15.JA

Abstract

Increased lifespans have led to population aging and brought attention to healthcare concerns associated with old age. A growing body of preclinical and clinical research has identified neurological benefits associated with the consumption of berry fruits. In addition to their now well-known antioxidant effects, dietary supplementation with berry fruits also has direct effects on the brain. Intake of these fruits may help to prevent age-related neurodegeneration and resulting changes in cognitive and motor function. In cell and animal models, berry fruits mediate signaling pathways involved in inflammation and cell survival in addition to enhancing neuroplasticity, neurotransmission, and calcium buffering, all of which lead to attenuation of age- and pathology-related deficits in behavior. Recent clinical trials have extended these antioxidant, anti-inflammatory, and cognition-sparing effects to humans. This paper reviews recent evidence for the beneficial signaling effects of berry fruits on the brain and behavior.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University , 711 Washington Street, Boston, Massachusetts 02111, United States.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22264107

Citation

Miller, Marshall G., and Barbara Shukitt-Hale. "Berry Fruit Enhances Beneficial Signaling in the Brain." Journal of Agricultural and Food Chemistry, vol. 60, no. 23, 2012, pp. 5709-15.
Miller MG, Shukitt-Hale B. Berry fruit enhances beneficial signaling in the brain. J Agric Food Chem. 2012;60(23):5709-15.
Miller, M. G., & Shukitt-Hale, B. (2012). Berry fruit enhances beneficial signaling in the brain. Journal of Agricultural and Food Chemistry, 60(23), 5709-15. https://doi.org/10.1021/jf2036033
Miller MG, Shukitt-Hale B. Berry Fruit Enhances Beneficial Signaling in the Brain. J Agric Food Chem. 2012 Jun 13;60(23):5709-15. PubMed PMID: 22264107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Berry fruit enhances beneficial signaling in the brain. AU - Miller,Marshall G, AU - Shukitt-Hale,Barbara, Y1 - 2012/02/03/ PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2014/7/19/medline SP - 5709 EP - 15 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 60 IS - 23 N2 - Increased lifespans have led to population aging and brought attention to healthcare concerns associated with old age. A growing body of preclinical and clinical research has identified neurological benefits associated with the consumption of berry fruits. In addition to their now well-known antioxidant effects, dietary supplementation with berry fruits also has direct effects on the brain. Intake of these fruits may help to prevent age-related neurodegeneration and resulting changes in cognitive and motor function. In cell and animal models, berry fruits mediate signaling pathways involved in inflammation and cell survival in addition to enhancing neuroplasticity, neurotransmission, and calcium buffering, all of which lead to attenuation of age- and pathology-related deficits in behavior. Recent clinical trials have extended these antioxidant, anti-inflammatory, and cognition-sparing effects to humans. This paper reviews recent evidence for the beneficial signaling effects of berry fruits on the brain and behavior. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/22264107/Berry_fruit_enhances_beneficial_signaling_in_the_brain_ L2 - https://doi.org/10.1021/jf2036033 DB - PRIME DP - Unbound Medicine ER -