Tags

Type your tag names separated by a space and hit enter

Plasma triglyceride levels increase the risk for recurrent vascular events independent of LDL-cholesterol or nonHDL-cholesterol.
Int J Cardiol. 2013 Jul 31; 167(2):403-8.IJ

Abstract

BACKGROUND

Plasma triglyceride (TG) levels are known to confer an increased risk of vascular disease in healthy populations, but data in high-risk patients are scarce. In this study we evaluated the risk on recurrent vascular events conferred by increased plasma TG levels in patients with various clinical manifestations of vascular disease.

METHODS

Prospective cohort study of 5731 patients with clinically manifest vascular disease.

RESULTS

First new vascular events (myocardial infarction, ischemic stroke, vascular death) occurred in 782 subjects during a median follow-up of 4.9 years (interquartile range 2.5-8.1 years). Patients in the highest plasma TG quintile (>2.24 mmol/L) had a higher risk for recurrent vascular events (HR 1.45; 95%CI 1.13-1.86) compared with the lowest plasma TG quintile (<0.97 mmol/L) after adjustments for age, gender, body mass index, smoking, lipid-lowering medication and low-density lipoprotein-cholesterol. The increased risk associated with increasing plasma TG levels was irrespective of the presence of type 2 diabetes (T2DM), but only present in patients without the metabolic syndrome. Furthermore, the increased risk was particularly present in patients with coronary artery disease (CAD) (HR 1.45; 95%CI 1.02-2.08) and was not modified by other lipid levels (p-value for interaction >0.05). Plasma TG still contributed to vascular risk when other lipid levels were at target level.

CONCLUSIONS

Higher plasma TG levels are associated with increased risk for recurrent vascular events, in particular in CAD patients. This increased risk is independent of the presence of T2DM and the use of lipid-lowering medication and is not modified by other lipid levels.

Authors+Show Affiliations

Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22265582

Citation

van de Woestijne, Anton P., et al. "Plasma Triglyceride Levels Increase the Risk for Recurrent Vascular Events Independent of LDL-cholesterol or NonHDL-cholesterol." International Journal of Cardiology, vol. 167, no. 2, 2013, pp. 403-8.
van de Woestijne AP, Wassink AM, Monajemi H, et al. Plasma triglyceride levels increase the risk for recurrent vascular events independent of LDL-cholesterol or nonHDL-cholesterol. Int J Cardiol. 2013;167(2):403-8.
van de Woestijne, A. P., Wassink, A. M., Monajemi, H., Liem, A. H., Nathoe, H. M., van der Graaf, Y., & Visseren, F. L. (2013). Plasma triglyceride levels increase the risk for recurrent vascular events independent of LDL-cholesterol or nonHDL-cholesterol. International Journal of Cardiology, 167(2), 403-8. https://doi.org/10.1016/j.ijcard.2012.01.008
van de Woestijne AP, et al. Plasma Triglyceride Levels Increase the Risk for Recurrent Vascular Events Independent of LDL-cholesterol or NonHDL-cholesterol. Int J Cardiol. 2013 Jul 31;167(2):403-8. PubMed PMID: 22265582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma triglyceride levels increase the risk for recurrent vascular events independent of LDL-cholesterol or nonHDL-cholesterol. AU - van de Woestijne,Anton P, AU - Wassink,Annemarie M J, AU - Monajemi,Houshang, AU - Liem,An-Ho, AU - Nathoe,Hendrik M, AU - van der Graaf,Yolanda, AU - Visseren,Frank L J, AU - ,, Y1 - 2012/01/21/ PY - 2011/10/07/received PY - 2011/12/23/revised PY - 2012/01/01/accepted PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2014/2/25/medline SP - 403 EP - 8 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 167 IS - 2 N2 - BACKGROUND: Plasma triglyceride (TG) levels are known to confer an increased risk of vascular disease in healthy populations, but data in high-risk patients are scarce. In this study we evaluated the risk on recurrent vascular events conferred by increased plasma TG levels in patients with various clinical manifestations of vascular disease. METHODS: Prospective cohort study of 5731 patients with clinically manifest vascular disease. RESULTS: First new vascular events (myocardial infarction, ischemic stroke, vascular death) occurred in 782 subjects during a median follow-up of 4.9 years (interquartile range 2.5-8.1 years). Patients in the highest plasma TG quintile (>2.24 mmol/L) had a higher risk for recurrent vascular events (HR 1.45; 95%CI 1.13-1.86) compared with the lowest plasma TG quintile (<0.97 mmol/L) after adjustments for age, gender, body mass index, smoking, lipid-lowering medication and low-density lipoprotein-cholesterol. The increased risk associated with increasing plasma TG levels was irrespective of the presence of type 2 diabetes (T2DM), but only present in patients without the metabolic syndrome. Furthermore, the increased risk was particularly present in patients with coronary artery disease (CAD) (HR 1.45; 95%CI 1.02-2.08) and was not modified by other lipid levels (p-value for interaction >0.05). Plasma TG still contributed to vascular risk when other lipid levels were at target level. CONCLUSIONS: Higher plasma TG levels are associated with increased risk for recurrent vascular events, in particular in CAD patients. This increased risk is independent of the presence of T2DM and the use of lipid-lowering medication and is not modified by other lipid levels. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/22265582/Plasma_triglyceride_levels_increase_the_risk_for_recurrent_vascular_events_independent_of_LDL_cholesterol_or_nonHDL_cholesterol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(12)00011-3 DB - PRIME DP - Unbound Medicine ER -