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Byrsonima intermedia A. Juss.: gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models.
J Ethnopharmacol. 2012 Mar 27; 140(2):203-12.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

An ethnopharmacological survey indicated that the leaves of Byrsonima intermedia A. Juss. (Malpighiaceae), a medicinal species commonly found in the Brazilian Cerrado, can be used against gastroduodenal disorders, such as gastric ulcers and diarrhea.

AIM OF THE STUDY

The objective of this study was to evaluate the effects of a methanolic extract of Byrsonima intermedia (MBI) leaves on gastric and duodenal ulcers and to assess the antimicrobial and antidiarrheal effects of this extract.

MATERIAL AND METHODS

The anti-ulcerogenic effect of MBI was investigated with different ulcerogenic agents in rodents (mice and rats), including non-steroidal anti-inflammatory drug (NSAID), HCl/ethanol, pyloric ligature, absolute ethanol, cysteamine and ischemia-reperfusion. The gastroprotective effect of MBI was assessed by analysing the volume of gastric juice, pH, total acidity, mucus, NO, sulfhydryl compound, vanilloid receptor, glutathione (GSH) levels, and myeloperoxidase (MPO) activity in the gastric and duodenal mucosa. The gastric and duodenal healing effects of MBI were also evaluated during 7 or 14 days of treatment. The antidiarrheal action (measured by intestinal motility and diarrhea induced by castor oil) and anti-bacterial action of MBI against Staphylococcus aureus, Escherichia coli and Helicobacter pylori were also evaluated by microdilution methods.

RESULTS

The phytochemical profile from MBI indicated the presence of phenolic acids, flavan-3-ols, oligomeric proanthocyanidins, and flavonoids. MBI (500mg/kg, p.o.) significantly inhibited totally gastric and duodenal lesions (69%) and healed gastric (49% on 14 days) and duodenal lesions (45% on 7 and 14 days). The MBI exert gastroprotective action by participation of endogenous sulfhydryl compounds, vanilloid receptors and increase in GSH level to effective gastric and duodenal protection. MBI also displayed curative (42%) and preventive (49%) antidiarrheal effects by involvement of opiate receptors and also antimicrobial effects in vitro.

CONCLUSIONS

Byrsonima intermedia leaves present gastroprotective, healing and antidiarrheal activities, supporting previous claims that its traditional use can treat gastrointestinal disorders.

Authors+Show Affiliations

Univ. Estadual Paulista-UNESP - Departamento de Fisiologia, Instituto de Biociências, cp 510, CEP 18618-970, Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22265748

Citation

Santos, Raquel Cássia, et al. "Byrsonima Intermedia A. Juss.: Gastric and Duodenal Anti-ulcer, Antimicrobial and Antidiarrheal Effects in Experimental Rodent Models." Journal of Ethnopharmacology, vol. 140, no. 2, 2012, pp. 203-12.
Santos RC, Kushima H, Rodrigues CM, et al. Byrsonima intermedia A. Juss.: gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models. J Ethnopharmacol. 2012;140(2):203-12.
Santos, R. C., Kushima, H., Rodrigues, C. M., Sannomiya, M., Rocha, L. R., Bauab, T. M., Tamashiro, J., Vilegas, W., & Hiruma-Lima, C. A. (2012). Byrsonima intermedia A. Juss.: gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models. Journal of Ethnopharmacology, 140(2), 203-12. https://doi.org/10.1016/j.jep.2011.12.008
Santos RC, et al. Byrsonima Intermedia A. Juss.: Gastric and Duodenal Anti-ulcer, Antimicrobial and Antidiarrheal Effects in Experimental Rodent Models. J Ethnopharmacol. 2012 Mar 27;140(2):203-12. PubMed PMID: 22265748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Byrsonima intermedia A. Juss.: gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models. AU - Santos,Raquel Cássia, AU - Kushima,Hélio, AU - Rodrigues,Clenilson Martins, AU - Sannomiya,Miriam, AU - Rocha,Lúcia Regina Machado, AU - Bauab,Taís Maria, AU - Tamashiro,Jorge, AU - Vilegas,Wagner, AU - Hiruma-Lima,Clélia Akiko, Y1 - 2012/01/13/ PY - 2011/08/14/received PY - 2011/11/18/revised PY - 2011/12/02/accepted PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2012/8/3/medline SP - 203 EP - 12 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 140 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: An ethnopharmacological survey indicated that the leaves of Byrsonima intermedia A. Juss. (Malpighiaceae), a medicinal species commonly found in the Brazilian Cerrado, can be used against gastroduodenal disorders, such as gastric ulcers and diarrhea. AIM OF THE STUDY: The objective of this study was to evaluate the effects of a methanolic extract of Byrsonima intermedia (MBI) leaves on gastric and duodenal ulcers and to assess the antimicrobial and antidiarrheal effects of this extract. MATERIAL AND METHODS: The anti-ulcerogenic effect of MBI was investigated with different ulcerogenic agents in rodents (mice and rats), including non-steroidal anti-inflammatory drug (NSAID), HCl/ethanol, pyloric ligature, absolute ethanol, cysteamine and ischemia-reperfusion. The gastroprotective effect of MBI was assessed by analysing the volume of gastric juice, pH, total acidity, mucus, NO, sulfhydryl compound, vanilloid receptor, glutathione (GSH) levels, and myeloperoxidase (MPO) activity in the gastric and duodenal mucosa. The gastric and duodenal healing effects of MBI were also evaluated during 7 or 14 days of treatment. The antidiarrheal action (measured by intestinal motility and diarrhea induced by castor oil) and anti-bacterial action of MBI against Staphylococcus aureus, Escherichia coli and Helicobacter pylori were also evaluated by microdilution methods. RESULTS: The phytochemical profile from MBI indicated the presence of phenolic acids, flavan-3-ols, oligomeric proanthocyanidins, and flavonoids. MBI (500mg/kg, p.o.) significantly inhibited totally gastric and duodenal lesions (69%) and healed gastric (49% on 14 days) and duodenal lesions (45% on 7 and 14 days). The MBI exert gastroprotective action by participation of endogenous sulfhydryl compounds, vanilloid receptors and increase in GSH level to effective gastric and duodenal protection. MBI also displayed curative (42%) and preventive (49%) antidiarrheal effects by involvement of opiate receptors and also antimicrobial effects in vitro. CONCLUSIONS: Byrsonima intermedia leaves present gastroprotective, healing and antidiarrheal activities, supporting previous claims that its traditional use can treat gastrointestinal disorders. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22265748/Byrsonima_intermedia_A__Juss_:_gastric_and_duodenal_anti_ulcer_antimicrobial_and_antidiarrheal_effects_in_experimental_rodent_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00875-0 DB - PRIME DP - Unbound Medicine ER -