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Prospective genotyping of human rhinoviruses in children and adults during the winter of 2009-2010.
J Clin Virol. 2012 Apr; 53(4):280-4.JC

Abstract

BACKGROUND

About 100 serotypes of human rhinovirus (HRV), classified into two species, have been identified by 1990. Uncultivable HRV variants have recently been identified and designated a new species. Recent improved diagnosis has led to a re-appraisal of the clinical impact of HRV infections in lower respiratory diseases.

OBJECTIVES

To characterise clinical features in hospitalised patients with positive HRV RNA detection and to determine the distribution of HRV species in respiratory infections diagnosed during the winter of 2009-2010.

STUDY DESIGN

Prospective virus typing was conducted by sequencing the VP4/VP2 genomic regions, and clinical data were collected.

RESULTS

Fifty-eight patients (for 63 respiratory specimens) were included. Phylogenetic analysis identified 52% of HRV species A, 6% of species B and 40% of species C, and revealed the co-circulation of 34 different HRV types during the study period. Three infants had successive infections with two or three different types. Five patients were admitted to an intensive care unit, four of them on arrival. Bronchiolitis, pneumonia and exacerbation of asthma were observed in 34/45 children. Pneumonia and severe exacerbation of chronic lung disease were observed in 8/13 adults, of whom 1, with immunocompromised status, died of multivisceral failure.

CONCLUSIONS

This study underlines the diversity of co-circulating strains and the potential severity of clinical presentations associated with HRV infections.

Authors+Show Affiliations

CHU de Clermont-Ferrand, Laboratoire de Virologie, F-63003 Clermont-Ferrand, France. chenquell@chu-clermontferrand.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22265827

Citation

Henquell, Cécile, et al. "Prospective Genotyping of Human Rhinoviruses in Children and Adults During the Winter of 2009-2010." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 53, no. 4, 2012, pp. 280-4.
Henquell C, Mirand A, Deusebis AL, et al. Prospective genotyping of human rhinoviruses in children and adults during the winter of 2009-2010. J Clin Virol. 2012;53(4):280-4.
Henquell, C., Mirand, A., Deusebis, A. L., Regagnon, C., Archimbaud, C., Chambon, M., Bailly, J. L., Gourdon, F., Hermet, E., Dauphin, J. B., Labbé, A., & Peigue-Lafeuille, H. (2012). Prospective genotyping of human rhinoviruses in children and adults during the winter of 2009-2010. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 53(4), 280-4. https://doi.org/10.1016/j.jcv.2011.10.009
Henquell C, et al. Prospective Genotyping of Human Rhinoviruses in Children and Adults During the Winter of 2009-2010. J Clin Virol. 2012;53(4):280-4. PubMed PMID: 22265827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective genotyping of human rhinoviruses in children and adults during the winter of 2009-2010. AU - Henquell,Cécile, AU - Mirand,Audrey, AU - Deusebis,Anne-Laure, AU - Regagnon,Christel, AU - Archimbaud,Christine, AU - Chambon,Martine, AU - Bailly,Jean-Luc, AU - Gourdon,Florence, AU - Hermet,Eric, AU - Dauphin,Jean-Benoît, AU - Labbé,André, AU - Peigue-Lafeuille,Hélène, Y1 - 2012/01/21/ PY - 2011/07/22/received PY - 2011/09/19/revised PY - 2011/10/18/accepted PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2012/7/6/medline SP - 280 EP - 4 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 53 IS - 4 N2 - BACKGROUND: About 100 serotypes of human rhinovirus (HRV), classified into two species, have been identified by 1990. Uncultivable HRV variants have recently been identified and designated a new species. Recent improved diagnosis has led to a re-appraisal of the clinical impact of HRV infections in lower respiratory diseases. OBJECTIVES: To characterise clinical features in hospitalised patients with positive HRV RNA detection and to determine the distribution of HRV species in respiratory infections diagnosed during the winter of 2009-2010. STUDY DESIGN: Prospective virus typing was conducted by sequencing the VP4/VP2 genomic regions, and clinical data were collected. RESULTS: Fifty-eight patients (for 63 respiratory specimens) were included. Phylogenetic analysis identified 52% of HRV species A, 6% of species B and 40% of species C, and revealed the co-circulation of 34 different HRV types during the study period. Three infants had successive infections with two or three different types. Five patients were admitted to an intensive care unit, four of them on arrival. Bronchiolitis, pneumonia and exacerbation of asthma were observed in 34/45 children. Pneumonia and severe exacerbation of chronic lung disease were observed in 8/13 adults, of whom 1, with immunocompromised status, died of multivisceral failure. CONCLUSIONS: This study underlines the diversity of co-circulating strains and the potential severity of clinical presentations associated with HRV infections. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/22265827/Prospective_genotyping_of_human_rhinoviruses_in_children_and_adults_during_the_winter_of_2009_2010_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(11)00427-6 DB - PRIME DP - Unbound Medicine ER -