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Synthesis, structures and urease inhibition studies of copper(II) and nickel(II) complexes with bidentate N,O-donor Schiff base ligands.
J Inorg Biochem. 2012 Mar; 108:22-9.JI

Abstract

Five mononuclear copper(II) and nickel(II) complexes of Schiff base ligands derived from 4-hydroxyphenethylamine and 2-phenylethylamine were synthesized and determined by single crystal X-ray analysis. The crystal structures of these complexes presented the square planar coordination geometry at the metal center. The inhibitory activity of all the obtained complexes was tested in vitro against jack bean urease. It was found that Schiff base copper(II) complexes, namely [Cu(C(15)H(13)BrNO(2))(2)]·2(C(6)H(7)N) (1), [Cu(C(15)H(12)Br(2)NO(2))(2)]·2(DMF) (2), Cu(C(19)H(16)NO(2))(2) (3) and Cu(C(19)H(16)NO)(2) (5), showed strong inhibitory activity against jack bean urease (IC(50)=1.45-3.59 μM), while Schiff base nickel(II) complex, [Ni(C(19)H(16)NO(2))(2)]·2(DMF) (4), exhibited weak inhibitory activity (IC(50)>50 μM). Their structure-activity relationships were further discussed.

Authors+Show Affiliations

School of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430073, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22265835

Citation

Dong, Xiongwei, et al. "Synthesis, Structures and Urease Inhibition Studies of copper(II) and nickel(II) Complexes With Bidentate N,O-donor Schiff Base Ligands." Journal of Inorganic Biochemistry, vol. 108, 2012, pp. 22-9.
Dong X, Li Y, Li Z, et al. Synthesis, structures and urease inhibition studies of copper(II) and nickel(II) complexes with bidentate N,O-donor Schiff base ligands. J Inorg Biochem. 2012;108:22-9.
Dong, X., Li, Y., Li, Z., Cui, Y., & Zhu, H. (2012). Synthesis, structures and urease inhibition studies of copper(II) and nickel(II) complexes with bidentate N,O-donor Schiff base ligands. Journal of Inorganic Biochemistry, 108, 22-9. https://doi.org/10.1016/j.jinorgbio.2011.12.006
Dong X, et al. Synthesis, Structures and Urease Inhibition Studies of copper(II) and nickel(II) Complexes With Bidentate N,O-donor Schiff Base Ligands. J Inorg Biochem. 2012;108:22-9. PubMed PMID: 22265835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, structures and urease inhibition studies of copper(II) and nickel(II) complexes with bidentate N,O-donor Schiff base ligands. AU - Dong,Xiongwei, AU - Li,Yuguang, AU - Li,Zuowen, AU - Cui,Yongming, AU - Zhu,Hailiang, Y1 - 2011/12/29/ PY - 2011/09/08/received PY - 2011/11/25/revised PY - 2011/12/21/accepted PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2012/7/6/medline SP - 22 EP - 9 JF - Journal of inorganic biochemistry JO - J Inorg Biochem VL - 108 N2 - Five mononuclear copper(II) and nickel(II) complexes of Schiff base ligands derived from 4-hydroxyphenethylamine and 2-phenylethylamine were synthesized and determined by single crystal X-ray analysis. The crystal structures of these complexes presented the square planar coordination geometry at the metal center. The inhibitory activity of all the obtained complexes was tested in vitro against jack bean urease. It was found that Schiff base copper(II) complexes, namely [Cu(C(15)H(13)BrNO(2))(2)]·2(C(6)H(7)N) (1), [Cu(C(15)H(12)Br(2)NO(2))(2)]·2(DMF) (2), Cu(C(19)H(16)NO(2))(2) (3) and Cu(C(19)H(16)NO)(2) (5), showed strong inhibitory activity against jack bean urease (IC(50)=1.45-3.59 μM), while Schiff base nickel(II) complex, [Ni(C(19)H(16)NO(2))(2)]·2(DMF) (4), exhibited weak inhibitory activity (IC(50)>50 μM). Their structure-activity relationships were further discussed. SN - 1873-3344 UR - https://www.unboundmedicine.com/medline/citation/22265835/Synthesis_structures_and_urease_inhibition_studies_of_copper_II__and_nickel_II__complexes_with_bidentate_NO_donor_Schiff_base_ligands_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0162-0134(11)00386-2 DB - PRIME DP - Unbound Medicine ER -