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Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days.
Food Chem Toxicol 2012; 50(6):1911-9FC

Abstract

Recently, steps have been taken to further developments toward increasing gamma-linolenic acid (GLA) concentration and lowering costs in plant seed oils using transgenic technology. Through identification and expression of a fungal delta-6 desaturase gene in the high linoleic acid safflower plant, the seeds from this genetic transformation produce oil with >40% GLA (high GLA safflower oil (HGSO)). The aim of the study was to compare the effects of feeding HGSO to a generally recognized as safe source of GLA, borage oil, in a 90 day safety study in rats. Weanling male and female Sprague-Dawley rats were fed a semi-synthetic, fat free, pelleted diet (AIN93G) supplemented with a 10% (wt/wt) oil blend containing HGSO or borage oil, with equivalent GLA levels. Results demonstrated that feeding diets containing HGSO or borage oil for 90 days had similar biologic effects with regard to growth characteristics, body composition, behavior, organ weight and histology, and parameters of hematology and serum biochemistries in both sexes. Metabolism of the primary n-6 fatty acids in plasma and organ phospholipids was similar, despite minor changes in females. We conclude that HGSO is biologically equivalent to borage oil and provides a safe alternative source of GLA in the diet.

Authors+Show Affiliations

Department of Pathology, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237-0507, USA. tsopp@ucmail.uc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22265940

Citation

Tso, Patrick, et al. "Comparison of Growth, Serum Biochemistries and N-6 Fatty Acid Metabolism in Rats Fed Diets Supplemented With High-gamma-linolenic Acid Safflower Oil or Borage Oil for 90 Days." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 50, no. 6, 2012, pp. 1911-9.
Tso P, Caldwell J, Lee D, et al. Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. Food Chem Toxicol. 2012;50(6):1911-9.
Tso, P., Caldwell, J., Lee, D., Boivin, G. P., & DeMichele, S. J. (2012). Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 50(6), pp. 1911-9. doi:10.1016/j.fct.2012.01.001.
Tso P, et al. Comparison of Growth, Serum Biochemistries and N-6 Fatty Acid Metabolism in Rats Fed Diets Supplemented With High-gamma-linolenic Acid Safflower Oil or Borage Oil for 90 Days. Food Chem Toxicol. 2012;50(6):1911-9. PubMed PMID: 22265940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days. AU - Tso,Patrick, AU - Caldwell,Jody, AU - Lee,Dana, AU - Boivin,Gregory P, AU - DeMichele,Stephen J, Y1 - 2012/01/12/ PY - 2011/10/07/received PY - 2012/01/03/revised PY - 2012/01/05/accepted PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2012/10/10/medline SP - 1911 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 50 IS - 6 N2 - Recently, steps have been taken to further developments toward increasing gamma-linolenic acid (GLA) concentration and lowering costs in plant seed oils using transgenic technology. Through identification and expression of a fungal delta-6 desaturase gene in the high linoleic acid safflower plant, the seeds from this genetic transformation produce oil with >40% GLA (high GLA safflower oil (HGSO)). The aim of the study was to compare the effects of feeding HGSO to a generally recognized as safe source of GLA, borage oil, in a 90 day safety study in rats. Weanling male and female Sprague-Dawley rats were fed a semi-synthetic, fat free, pelleted diet (AIN93G) supplemented with a 10% (wt/wt) oil blend containing HGSO or borage oil, with equivalent GLA levels. Results demonstrated that feeding diets containing HGSO or borage oil for 90 days had similar biologic effects with regard to growth characteristics, body composition, behavior, organ weight and histology, and parameters of hematology and serum biochemistries in both sexes. Metabolism of the primary n-6 fatty acids in plasma and organ phospholipids was similar, despite minor changes in females. We conclude that HGSO is biologically equivalent to borage oil and provides a safe alternative source of GLA in the diet. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/22265940/Comparison_of_growth_serum_biochemistries_and_n_6_fatty_acid_metabolism_in_rats_fed_diets_supplemented_with_high_gamma_linolenic_acid_safflower_oil_or_borage_oil_for_90_days_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(12)00010-5 DB - PRIME DP - Unbound Medicine ER -