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Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy.
AJR Am J Roentgenol. 2012 Feb; 198(2):W141-5.AA

Abstract

OBJECTIVE

The objective of our study was to assess the incidence of associated malignancy when microscopic radial scars and microscopic intraductal papillomas are encountered at percutaneous biopsy for lesions that otherwise reveal benign histopathology.

MATERIALS AND METHODS

A search of the pathology database for the period from December 14, 2006, through December 21, 2009, identified patients with a microscopic radial scar, a microscopic intraductal papilloma, or both at percutaneous biopsy. Patients whose percutaneous biopsy was performed for a lesion that revealed carcinoma or a high-risk pathology result were excluded to avoid confounding bias, as were patients who had only imaging follow-up. Only patients who underwent surgery solely for the study lesion were included. The lesion type that prompted core biopsy, biopsy guidance and device, sample number, and surgical outcomes were recorded. The incidences of benign, high-risk, and malignant pathology findings from surgery were calculated.

RESULTS

The search revealed 35 patients (18 microscopic radial scars, 17 microscopic papillomas) who underwent surgery solely for the study lesion. Stereotactic guidance was used for 15 (43%); ultrasound, for 12 (34%); and MRI, for eight (23%). At surgery, 12 patients (34%) had high-risk histopathology results and 23 (66%) had benign results. No study lesions were upgraded to malignancy.

CONCLUSION

Our study found no evidence of associated malignancy at surgical excision when microscopic radial scars and microscopic intraductal papillomas were encountered at percutaneous biopsy in patients who otherwise had benign histopathology results; thus, routine imaging follow-up may be performed.

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Authors+Show Affiliations

Lee KA
Breast Imaging, Department of Radiology, Magee-Women's Hospital of the University of Pittsburgh Medical Center, 300 Halket St, Pittsburgh, PA 15213, USA.
Zuley ML
No affiliation info available
Chivukula M
No affiliation info available
Choksi ND
No affiliation info available
Ganott MA
No affiliation info available
Sumkin JH
No affiliation info available

MeSH

Biopsy, NeedleBreast NeoplasmsCicatrixFemaleFollow-Up StudiesHumansIncidenceMammographyMiddle AgedPapilloma, IntraductalRadiography, InterventionalRetrospective StudiesRisk AssessmentUltrasonography, InterventionalUltrasonography, MammaryVacuum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22268203

Citation

Lee, Karen A., et al. "Risk of Malignancy when Microscopic Radial Scars and Microscopic Papillomas Are Found at Percutaneous Biopsy." AJR. American Journal of Roentgenology, vol. 198, no. 2, 2012, pp. W141-5.
Lee KA, Zuley ML, Chivukula M, et al. Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy. AJR Am J Roentgenol. 2012;198(2):W141-5.
Lee, K. A., Zuley, M. L., Chivukula, M., Choksi, N. D., Ganott, M. A., & Sumkin, J. H. (2012). Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy. AJR. American Journal of Roentgenology, 198(2), W141-5. https://doi.org/10.2214/AJR.11.7712
Lee KA, et al. Risk of Malignancy when Microscopic Radial Scars and Microscopic Papillomas Are Found at Percutaneous Biopsy. AJR Am J Roentgenol. 2012;198(2):W141-5. PubMed PMID: 22268203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy. AU - Lee,Karen A, AU - Zuley,Margarita L, AU - Chivukula,Mamatha, AU - Choksi,Neha Desai, AU - Ganott,Marie A, AU - Sumkin,Jules H, PY - 2012/1/24/entrez PY - 2012/1/24/pubmed PY - 2012/4/4/medline SP - W141 EP - 5 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 198 IS - 2 N2 - OBJECTIVE: The objective of our study was to assess the incidence of associated malignancy when microscopic radial scars and microscopic intraductal papillomas are encountered at percutaneous biopsy for lesions that otherwise reveal benign histopathology. MATERIALS AND METHODS: A search of the pathology database for the period from December 14, 2006, through December 21, 2009, identified patients with a microscopic radial scar, a microscopic intraductal papilloma, or both at percutaneous biopsy. Patients whose percutaneous biopsy was performed for a lesion that revealed carcinoma or a high-risk pathology result were excluded to avoid confounding bias, as were patients who had only imaging follow-up. Only patients who underwent surgery solely for the study lesion were included. The lesion type that prompted core biopsy, biopsy guidance and device, sample number, and surgical outcomes were recorded. The incidences of benign, high-risk, and malignant pathology findings from surgery were calculated. RESULTS: The search revealed 35 patients (18 microscopic radial scars, 17 microscopic papillomas) who underwent surgery solely for the study lesion. Stereotactic guidance was used for 15 (43%); ultrasound, for 12 (34%); and MRI, for eight (23%). At surgery, 12 patients (34%) had high-risk histopathology results and 23 (66%) had benign results. No study lesions were upgraded to malignancy. CONCLUSION: Our study found no evidence of associated malignancy at surgical excision when microscopic radial scars and microscopic intraductal papillomas were encountered at percutaneous biopsy in patients who otherwise had benign histopathology results; thus, routine imaging follow-up may be performed. SN - 1546-3141 UR - https://www.unboundmedicine.com/medline/citation/22268203/Risk_of_malignancy_when_microscopic_radial_scars_and_microscopic_papillomas_are_found_at_percutaneous_biopsy_ L2 - https://www.ajronline.org/doi/10.2214/AJR.11.7712 DB - PRIME DP - Unbound Medicine ER -