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Disturbed correlation between arterial resistance and pulsatility in glaucoma patients.
Acta Ophthalmol. 2012 May; 90(3):e214-20.AO

Abstract

PURPOSE

(i) To investigate whether pulsatility index (PI) and mean flow velocities (MFV) are altered in glaucoma patients. (ii) To evaluate the significance of PI in retrobulbar autoregulation capacity.

METHODS

Patients with primary open-angle glaucoma (POAG; n = 49), normal tension glaucoma (NTG; n = 62) and healthy controls (n = 48) underwent colour Doppler imaging measurements of the retrobulbar vasculature. Kruskal-Wallis test was used to compare variables between the three diagnostic groups. Restricted cubic splines were used to determine nonlinearities between the resistive index (RI) and PI correlations.

RESULTS

Mean flow velocities (MFV) were lower in both short posterior ciliary arteries (SCPA) and central retinal arteries (CRA) from the two glaucoma groups (p < 0.04 versus healthy controls). No differences were detected in RI or PI in any arteries of the three diagnostic groups (p > 0.08). In healthy individuals, correlations between RI and PI were linear in all arteries. In both POAG and NTG patients, CRA presented a nonlinear curve with a cutpoint at RI 0.77 (p < 0.001) and 0.61 (p = 0.03), respectively, above which the slope increased nearly five- and tenfold (POAG: 1.96 to 10.06; NTG: -0.46-4.06), respectively. A nonlinear correlation in the ophthalmic artery was only observed in NTG patients, with a cutpoint at RI 0.82 (p < 0.001), above which the slope increased from 3.47 to 14.03.

CONCLUSIONS

Glaucoma patients do not present the linear relationships between RI and PI observed in healthy individuals. Their nonlinear relations may be indicative of an altered autoregulation and suggest a possible threshold RI could be determined above which autoregulatory disturbances become more relevant.

Authors+Show Affiliations

Department of Ophthalmology, Centro Hospitalar de Lisboa Central, Portugal.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22268445

Citation

Abegão Pinto, Luís, et al. "Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients." Acta Ophthalmologica, vol. 90, no. 3, 2012, pp. e214-20.
Abegão Pinto L, Vandewalle E, Stalmans I. Disturbed correlation between arterial resistance and pulsatility in glaucoma patients. Acta Ophthalmol. 2012;90(3):e214-20.
Abegão Pinto, L., Vandewalle, E., & Stalmans, I. (2012). Disturbed correlation between arterial resistance and pulsatility in glaucoma patients. Acta Ophthalmologica, 90(3), e214-20. https://doi.org/10.1111/j.1755-3768.2011.02335.x
Abegão Pinto L, Vandewalle E, Stalmans I. Disturbed Correlation Between Arterial Resistance and Pulsatility in Glaucoma Patients. Acta Ophthalmol. 2012;90(3):e214-20. PubMed PMID: 22268445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disturbed correlation between arterial resistance and pulsatility in glaucoma patients. AU - Abegão Pinto,Luís, AU - Vandewalle,Evelien, AU - Stalmans,Ingeborg, Y1 - 2012/01/23/ PY - 2012/1/25/entrez PY - 2012/1/25/pubmed PY - 2012/7/14/medline SP - e214 EP - 20 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 90 IS - 3 N2 - PURPOSE: (i) To investigate whether pulsatility index (PI) and mean flow velocities (MFV) are altered in glaucoma patients. (ii) To evaluate the significance of PI in retrobulbar autoregulation capacity. METHODS: Patients with primary open-angle glaucoma (POAG; n = 49), normal tension glaucoma (NTG; n = 62) and healthy controls (n = 48) underwent colour Doppler imaging measurements of the retrobulbar vasculature. Kruskal-Wallis test was used to compare variables between the three diagnostic groups. Restricted cubic splines were used to determine nonlinearities between the resistive index (RI) and PI correlations. RESULTS: Mean flow velocities (MFV) were lower in both short posterior ciliary arteries (SCPA) and central retinal arteries (CRA) from the two glaucoma groups (p < 0.04 versus healthy controls). No differences were detected in RI or PI in any arteries of the three diagnostic groups (p > 0.08). In healthy individuals, correlations between RI and PI were linear in all arteries. In both POAG and NTG patients, CRA presented a nonlinear curve with a cutpoint at RI 0.77 (p < 0.001) and 0.61 (p = 0.03), respectively, above which the slope increased nearly five- and tenfold (POAG: 1.96 to 10.06; NTG: -0.46-4.06), respectively. A nonlinear correlation in the ophthalmic artery was only observed in NTG patients, with a cutpoint at RI 0.82 (p < 0.001), above which the slope increased from 3.47 to 14.03. CONCLUSIONS: Glaucoma patients do not present the linear relationships between RI and PI observed in healthy individuals. Their nonlinear relations may be indicative of an altered autoregulation and suggest a possible threshold RI could be determined above which autoregulatory disturbances become more relevant. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/22268445/Disturbed_correlation_between_arterial_resistance_and_pulsatility_in_glaucoma_patients_ L2 - https://doi.org/10.1111/j.1755-3768.2011.02335.x DB - PRIME DP - Unbound Medicine ER -