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Comparison of different glomerular filtration methods in the elderly: which formula provides better estimates?
Ren Fail. 2012; 34(4):435-41.RF

Abstract

OBJECTIVES

Technetium-99m diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) is an ideal radioisotopic method having a high correlation with inulin clearance for the determination of glomerular filtration rate (GFR). Different formulas like creatinine clearance (CrCl) in 24 h urine samples, Cockroft-Gault formula (CGF), and modification of diet in renal disease (MDRD) are being used to come up with an estimate. In this study, we compared (99m)Tc-DTPA with the formulas mentioned above in an attempt to best identify the method that would yield the nearly ideal GFR estimates in the elderly.

MATERIALS AND METHODS

In 76 patients who were admitted to our clinic, we measured 24 h urine volume (V), urine creatinine (Ucr), and serum creatinine (Scr) levels together with CrCl, Scr, serum urea (Su), and albumin (Alb) levels. By using coefficients identified for age, gender, and race, we calculated modification of diet in renal disease 1 (MDRD1). Different from MDRD1, we calculated modification of diet in renal disease 2 (MDRD2) that does not include Su and Alb parameters and formulas like CGF that include Scr, age, gender, and weight parameters to come up with GFR levels. All patients underwent (99m)Tc-DTPA procedure.

RESULTS

The mean of the GFR values measured by (99m)Tc-DTPA was 54.3 ± 19.9. The means of GFR values calculated by CrCl, MDRD1, MDRD2, and CGF were 58.0 ± 30.5, 60.9 ± 22.1, 54.4 ± 20.1, and 57.9 ± 22.4, respectively. GFR as measured by (99m)Tc-DTPA showed statistically significant correlations with the results of other methods (p < 0.001 for all methods). The most significant correlation was with MDRD1.

CONCLUSION

MDRD1 can be used for next to ideal and accurate predictions of GFR in the elderly in the daily practice.

Authors+Show Affiliations

Department of Geriatric Medicine, School of Medicine, Ankara University, Ankara, Turkey. sevgidursun06@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22268784

Citation

Aras, Sevgi, et al. "Comparison of Different Glomerular Filtration Methods in the Elderly: Which Formula Provides Better Estimates?" Renal Failure, vol. 34, no. 4, 2012, pp. 435-41.
Aras S, Varli M, Uzun B, et al. Comparison of different glomerular filtration methods in the elderly: which formula provides better estimates? Ren Fail. 2012;34(4):435-41.
Aras, S., Varli, M., Uzun, B., Atli, T., Keven, K., & Turgay, M. (2012). Comparison of different glomerular filtration methods in the elderly: which formula provides better estimates? Renal Failure, 34(4), 435-41. https://doi.org/10.3109/0886022X.2011.654168
Aras S, et al. Comparison of Different Glomerular Filtration Methods in the Elderly: Which Formula Provides Better Estimates. Ren Fail. 2012;34(4):435-41. PubMed PMID: 22268784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of different glomerular filtration methods in the elderly: which formula provides better estimates? AU - Aras,Sevgi, AU - Varli,Murat, AU - Uzun,Burcu, AU - Atli,Teslime, AU - Keven,Kenan, AU - Turgay,Murat, Y1 - 2012/01/24/ PY - 2012/1/25/entrez PY - 2012/1/25/pubmed PY - 2012/8/29/medline SP - 435 EP - 41 JF - Renal failure JO - Ren Fail VL - 34 IS - 4 N2 - OBJECTIVES: Technetium-99m diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) is an ideal radioisotopic method having a high correlation with inulin clearance for the determination of glomerular filtration rate (GFR). Different formulas like creatinine clearance (CrCl) in 24 h urine samples, Cockroft-Gault formula (CGF), and modification of diet in renal disease (MDRD) are being used to come up with an estimate. In this study, we compared (99m)Tc-DTPA with the formulas mentioned above in an attempt to best identify the method that would yield the nearly ideal GFR estimates in the elderly. MATERIALS AND METHODS: In 76 patients who were admitted to our clinic, we measured 24 h urine volume (V), urine creatinine (Ucr), and serum creatinine (Scr) levels together with CrCl, Scr, serum urea (Su), and albumin (Alb) levels. By using coefficients identified for age, gender, and race, we calculated modification of diet in renal disease 1 (MDRD1). Different from MDRD1, we calculated modification of diet in renal disease 2 (MDRD2) that does not include Su and Alb parameters and formulas like CGF that include Scr, age, gender, and weight parameters to come up with GFR levels. All patients underwent (99m)Tc-DTPA procedure. RESULTS: The mean of the GFR values measured by (99m)Tc-DTPA was 54.3 ± 19.9. The means of GFR values calculated by CrCl, MDRD1, MDRD2, and CGF were 58.0 ± 30.5, 60.9 ± 22.1, 54.4 ± 20.1, and 57.9 ± 22.4, respectively. GFR as measured by (99m)Tc-DTPA showed statistically significant correlations with the results of other methods (p < 0.001 for all methods). The most significant correlation was with MDRD1. CONCLUSION: MDRD1 can be used for next to ideal and accurate predictions of GFR in the elderly in the daily practice. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/22268784/Comparison_of_different_glomerular_filtration_methods_in_the_elderly:_which_formula_provides_better_estimates L2 - https://www.tandfonline.com/doi/full/10.3109/0886022X.2011.654168 DB - PRIME DP - Unbound Medicine ER -