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Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of vitiligo: a randomized controlled trial.
Dermatology. 2011; 223(4):343-8.D

Abstract

BACKGROUND

Limited data are available about the use of 308-nm monochromatic excimer light (MEL) and localized 311-nm narrow-band ultraviolet B (NB-UVB) in the treatment of vitiligo. The aim of this study was to evaluate the efficacy of 308-nm MEL versus localized 311-nm NB-UVB in vitiligo patients.

METHODS

Eleven patients participated in this prospective intrapatient placebo-controlled randomized trial. In each patient, 3 lesions were selected and treated with NB-UVB, MEL and placebo during 24 sessions, respectively. Repigmentation was evaluated clinically and by objective surface measurement.

RESULTS

Twenty percent of the lesions treated with NB-UVB achieved repigmentation scores above 50%. None of the lesions treated with MEL achieved a repigmentation higher than 50% after 24 sessions.

CONCLUSION

Localized 311-nm NB-UVB is effective in the treatment of vitiligo. It should be considered for localized vitiligo as it is easily accessible. In this study the efficacy of localized 311-nm NB-UVB was superior to 308-nm MEL.

Authors+Show Affiliations

Department of Dermatology, Ghent University Hospital, Ghent, Belgium. evelien.verhaeghe@ugent.beNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22269666

Citation

Verhaeghe, E, et al. "Intrapatient Comparison of 308-nm Monochromatic Excimer Light and Localized Narrow-band UVB Phototherapy in the Treatment of Vitiligo: a Randomized Controlled Trial." Dermatology (Basel, Switzerland), vol. 223, no. 4, 2011, pp. 343-8.
Verhaeghe E, Lodewick E, van Geel N, et al. Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of vitiligo: a randomized controlled trial. Dermatology (Basel). 2011;223(4):343-8.
Verhaeghe, E., Lodewick, E., van Geel, N., & Lambert, J. (2011). Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of vitiligo: a randomized controlled trial. Dermatology (Basel, Switzerland), 223(4), 343-8. https://doi.org/10.1159/000335272
Verhaeghe E, et al. Intrapatient Comparison of 308-nm Monochromatic Excimer Light and Localized Narrow-band UVB Phototherapy in the Treatment of Vitiligo: a Randomized Controlled Trial. Dermatology (Basel). 2011;223(4):343-8. PubMed PMID: 22269666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of vitiligo: a randomized controlled trial. AU - Verhaeghe,E, AU - Lodewick,E, AU - van Geel,N, AU - Lambert,J, Y1 - 2012/01/24/ PY - 2011/09/09/received PY - 2011/11/22/accepted PY - 2012/1/25/entrez PY - 2012/1/25/pubmed PY - 2012/7/18/medline SP - 343 EP - 8 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 223 IS - 4 N2 - BACKGROUND: Limited data are available about the use of 308-nm monochromatic excimer light (MEL) and localized 311-nm narrow-band ultraviolet B (NB-UVB) in the treatment of vitiligo. The aim of this study was to evaluate the efficacy of 308-nm MEL versus localized 311-nm NB-UVB in vitiligo patients. METHODS: Eleven patients participated in this prospective intrapatient placebo-controlled randomized trial. In each patient, 3 lesions were selected and treated with NB-UVB, MEL and placebo during 24 sessions, respectively. Repigmentation was evaluated clinically and by objective surface measurement. RESULTS: Twenty percent of the lesions treated with NB-UVB achieved repigmentation scores above 50%. None of the lesions treated with MEL achieved a repigmentation higher than 50% after 24 sessions. CONCLUSION: Localized 311-nm NB-UVB is effective in the treatment of vitiligo. It should be considered for localized vitiligo as it is easily accessible. In this study the efficacy of localized 311-nm NB-UVB was superior to 308-nm MEL. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/22269666/Intrapatient_comparison_of_308_nm_monochromatic_excimer_light_and_localized_narrow_band_UVB_phototherapy_in_the_treatment_of_vitiligo:_a_randomized_controlled_trial_ L2 - https://www.karger.com?DOI=10.1159/000335272 DB - PRIME DP - Unbound Medicine ER -