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Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women.
Osteoporos Int 2012; 23(11):2615-24OI

Abstract

Data on the impact of polyunsaturated fatty acid intake on hip fracture risk are inconsistent. We investigated this association in 75,878 women and 46,476 men and did not find a significant role for polyunsaturated fatty acid intake in the prevention of hip fractures.

INTRODUCTION

Polyunsaturated fatty acids (PUFA) are important in the prevention of chronic diseases, but studies of bone health report inconsistent results. Our aim was to investigate the association between dietary PUFA intake and risk of hip fracture in two large prospective cohorts of men and women with long follow-up times and frequently updated dietary data.

METHODS

The study population included 75,878 women and 46,476 men free of osteoporosis at baseline. Dietary intakes were assessed by a food frequency questionnaire at baseline and several times during the follow-up. Multivariable-adjusted Cox proportional hazards models were used to estimate relative risks (RR).

RESULTS

During 24 years of follow-up, we identified 1,051 hip fracture cases due to low or moderate trauma among the women and 529 cases among the men. In the pooled analyses, no statistically significant associations were found between intakes of total PUFA [RR in the highest vs. lowest quintile: 0.99, 95% confidence interval (CI) 0.69, 1.43; p value for trend is =0.83], total n-3 PUFA (RR 0.89, 95% CI 0.75, 1.06; p value for trend is =0.26), total n-6 PUFA (RR 0.99, 95% CI 0.71, 1.38; p value for trend is =0.82), n-6/n-3 PUFA ratio or individual PUFAs, and hip fracture risk. However, in women low intakes of total PUFA, total n-6 PUFA, and linoleic acid were associated with higher risk.

CONCLUSIONS

This study does not support a significant role for PUFA intake in the prevention of hip fractures, although low total PUFA, n-6 PUFA, or linoleic acid intakes may increase the risk in women.

Authors+Show Affiliations

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, 70211, Kuopio, Finland. jyrki.virtanen@uef.fiNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22270860

Citation

Virtanen, J K., et al. "Dietary Intake of Polyunsaturated Fatty Acids and Risk of Hip Fracture in Men and Women." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 23, no. 11, 2012, pp. 2615-24.
Virtanen JK, Mozaffarian D, Willett WC, et al. Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. Osteoporos Int. 2012;23(11):2615-24.
Virtanen, J. K., Mozaffarian, D., Willett, W. C., & Feskanich, D. (2012). Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 23(11), pp. 2615-24. doi:10.1007/s00198-012-1903-3.
Virtanen JK, et al. Dietary Intake of Polyunsaturated Fatty Acids and Risk of Hip Fracture in Men and Women. Osteoporos Int. 2012;23(11):2615-24. PubMed PMID: 22270860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. AU - Virtanen,J K, AU - Mozaffarian,D, AU - Willett,W C, AU - Feskanich,D, Y1 - 2012/01/21/ PY - 2011/10/27/received PY - 2011/11/28/accepted PY - 2012/1/25/entrez PY - 2012/1/25/pubmed PY - 2013/6/12/medline SP - 2615 EP - 24 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 23 IS - 11 N2 - UNLABELLED: Data on the impact of polyunsaturated fatty acid intake on hip fracture risk are inconsistent. We investigated this association in 75,878 women and 46,476 men and did not find a significant role for polyunsaturated fatty acid intake in the prevention of hip fractures. INTRODUCTION: Polyunsaturated fatty acids (PUFA) are important in the prevention of chronic diseases, but studies of bone health report inconsistent results. Our aim was to investigate the association between dietary PUFA intake and risk of hip fracture in two large prospective cohorts of men and women with long follow-up times and frequently updated dietary data. METHODS: The study population included 75,878 women and 46,476 men free of osteoporosis at baseline. Dietary intakes were assessed by a food frequency questionnaire at baseline and several times during the follow-up. Multivariable-adjusted Cox proportional hazards models were used to estimate relative risks (RR). RESULTS: During 24 years of follow-up, we identified 1,051 hip fracture cases due to low or moderate trauma among the women and 529 cases among the men. In the pooled analyses, no statistically significant associations were found between intakes of total PUFA [RR in the highest vs. lowest quintile: 0.99, 95% confidence interval (CI) 0.69, 1.43; p value for trend is =0.83], total n-3 PUFA (RR 0.89, 95% CI 0.75, 1.06; p value for trend is =0.26), total n-6 PUFA (RR 0.99, 95% CI 0.71, 1.38; p value for trend is =0.82), n-6/n-3 PUFA ratio or individual PUFAs, and hip fracture risk. However, in women low intakes of total PUFA, total n-6 PUFA, and linoleic acid were associated with higher risk. CONCLUSIONS: This study does not support a significant role for PUFA intake in the prevention of hip fractures, although low total PUFA, n-6 PUFA, or linoleic acid intakes may increase the risk in women. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/22270860/Dietary_intake_of_polyunsaturated_fatty_acids_and_risk_of_hip_fracture_in_men_and_women_ L2 - https://dx.doi.org/10.1007/s00198-012-1903-3 DB - PRIME DP - Unbound Medicine ER -