Tags

Type your tag names separated by a space and hit enter

Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats.
J Toxicol Pathol 2010; 23(4):245-51JT

Abstract

Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study.

Authors+Show Affiliations

Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22272034

Citation

Tago, Yoshiyuki, et al. "Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum Arvense in F344 Rats." Journal of Toxicologic Pathology, vol. 23, no. 4, 2010, pp. 245-51.
Tago Y, Wei M, Ishii N, et al. Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats. J Toxicol Pathol. 2010;23(4):245-51.
Tago, Y., Wei, M., Ishii, N., Kakehashi, A., & Wanibuchi, H. (2010). Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats. Journal of Toxicologic Pathology, 23(4), pp. 245-51. doi:10.1293/tox.23.245.
Tago Y, et al. Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum Arvense in F344 Rats. J Toxicol Pathol. 2010;23(4):245-51. PubMed PMID: 22272034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats. AU - Tago,Yoshiyuki, AU - Wei,Min, AU - Ishii,Naomi, AU - Kakehashi,Anna, AU - Wanibuchi,Hideki, Y1 - 2010/12/16/ PY - 2010/08/23/received PY - 2010/09/02/accepted PY - 2012/1/25/entrez PY - 2012/1/25/pubmed PY - 2012/1/25/medline KW - Equisetum arvense KW - F344 rat KW - NOAEL KW - horsetail KW - toxicity SP - 245 EP - 51 JF - Journal of toxicologic pathology JO - J Toxicol Pathol VL - 23 IS - 4 N2 - Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study. SN - 1881-915X UR - https://www.unboundmedicine.com/medline/citation/22272034/Evaluation_of_the_Subchronic_Toxicity_of_Dietary_Administered_Equisetum_arvense_in_F344_Rats_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0914-9198&volume=23&issue=4&spage=245 DB - PRIME DP - Unbound Medicine ER -