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The photopic negative response of the flash electroretinogram in multiple sclerosis.
Invest Ophthalmol Vis Sci. 2012 Mar; 53(3):1315-23.IO

Abstract

PURPOSE

To use the photopic electroretinogram (ERG) to evaluate retinal function in eyes of multiple sclerosis (MS) patients with and without a history of optic neuritis (ON) and to compare the functional and structural status of the inner retina.

METHODS

Full-field ERG responses to brief red flashes (0.04-2.8 cd · s/m²) on a rod-saturating blue background were recorded from 51 MS patients and 33 age-matched control subjects. In patients, perimetry was performed and peripapillary retinal nerve fiber layer thickness (RNFLT) was assessed by optical coherence tomography (OCT) and scanning laser polarimetry (SLP). MS eyes were separated into groups: "ON >6" months (n = 25), "ON <6" months (n = 29), and "no ON" (n = 33) based on positive or negative history of ON and time since the last episode. Thirteen ON<6 eyes were re-evaluated 1 year later.

RESULTS

PhNR amplitudes were lower in ON>6, ON<6, and no-ON eyes (mean ± SD, 17.3 ± 7.6, 16.0 ± 6.5, and 23.8 ± 9.3 μV, respectively), than in control eyes (29.8 ± 6.5 μV; P < 0.001) for a standard stimulus of 1.42 cd · s/m²; a- and b-wave amplitudes were unaffected. PhNR amplitudes correlated with visual fields mean deviation (MD) in ON>6 (r² = 0.43; P < 0.001) and no-ON eyes (r² = 0.10; P < 0.05), with similar results for weaker stimuli. PhNR amplitudes correlated with RNFLT in ON>6 eyes: OCT (r² = 0.52; P < 0.0001) and SLP (r² = 0.51; P < 0.01); and in no-ON eyes, OCT (r² = 0.21; P < 0.01) and SLP (r² = 0.17; P < 0.05). ON<6 amplitudes did not correlate significantly with other measures, but increased after 1 year by 5.1 ± 3.1 μV (P < 0.001), visual fields MD increased by 1.8 ± 2.3 dB (P < 0.05), and RNFL loss persisted.

CONCLUSIONS

Photopic ERG PhNR amplitudes in MS patients are significantly reduced in eyes with and without a history of ON.

Authors+Show Affiliations

College of Optometry, University of Houston, Houston, Texas, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22273726

Citation

Wang, Jing, et al. "The Photopic Negative Response of the Flash Electroretinogram in Multiple Sclerosis." Investigative Ophthalmology & Visual Science, vol. 53, no. 3, 2012, pp. 1315-23.
Wang J, Cheng H, Hu YS, et al. The photopic negative response of the flash electroretinogram in multiple sclerosis. Invest Ophthalmol Vis Sci. 2012;53(3):1315-23.
Wang, J., Cheng, H., Hu, Y. S., Tang, R. A., & Frishman, L. J. (2012). The photopic negative response of the flash electroretinogram in multiple sclerosis. Investigative Ophthalmology & Visual Science, 53(3), 1315-23. https://doi.org/10.1167/iovs.11-8461
Wang J, et al. The Photopic Negative Response of the Flash Electroretinogram in Multiple Sclerosis. Invest Ophthalmol Vis Sci. 2012;53(3):1315-23. PubMed PMID: 22273726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The photopic negative response of the flash electroretinogram in multiple sclerosis. AU - Wang,Jing, AU - Cheng,Han, AU - Hu,Ying-Sheng, AU - Tang,Rosa A, AU - Frishman,Laura J, Y1 - 2012/03/09/ PY - 2012/1/26/entrez PY - 2012/1/26/pubmed PY - 2012/5/9/medline SP - 1315 EP - 23 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 53 IS - 3 N2 - PURPOSE: To use the photopic electroretinogram (ERG) to evaluate retinal function in eyes of multiple sclerosis (MS) patients with and without a history of optic neuritis (ON) and to compare the functional and structural status of the inner retina. METHODS: Full-field ERG responses to brief red flashes (0.04-2.8 cd · s/m²) on a rod-saturating blue background were recorded from 51 MS patients and 33 age-matched control subjects. In patients, perimetry was performed and peripapillary retinal nerve fiber layer thickness (RNFLT) was assessed by optical coherence tomography (OCT) and scanning laser polarimetry (SLP). MS eyes were separated into groups: "ON >6" months (n = 25), "ON <6" months (n = 29), and "no ON" (n = 33) based on positive or negative history of ON and time since the last episode. Thirteen ON<6 eyes were re-evaluated 1 year later. RESULTS: PhNR amplitudes were lower in ON>6, ON<6, and no-ON eyes (mean ± SD, 17.3 ± 7.6, 16.0 ± 6.5, and 23.8 ± 9.3 μV, respectively), than in control eyes (29.8 ± 6.5 μV; P < 0.001) for a standard stimulus of 1.42 cd · s/m²; a- and b-wave amplitudes were unaffected. PhNR amplitudes correlated with visual fields mean deviation (MD) in ON>6 (r² = 0.43; P < 0.001) and no-ON eyes (r² = 0.10; P < 0.05), with similar results for weaker stimuli. PhNR amplitudes correlated with RNFLT in ON>6 eyes: OCT (r² = 0.52; P < 0.0001) and SLP (r² = 0.51; P < 0.01); and in no-ON eyes, OCT (r² = 0.21; P < 0.01) and SLP (r² = 0.17; P < 0.05). ON<6 amplitudes did not correlate significantly with other measures, but increased after 1 year by 5.1 ± 3.1 μV (P < 0.001), visual fields MD increased by 1.8 ± 2.3 dB (P < 0.05), and RNFL loss persisted. CONCLUSIONS: Photopic ERG PhNR amplitudes in MS patients are significantly reduced in eyes with and without a history of ON. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/22273726/The_photopic_negative_response_of_the_flash_electroretinogram_in_multiple_sclerosis_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.11-8461 DB - PRIME DP - Unbound Medicine ER -