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Familial factors associated with malignant gliomas.
Genet Epidemiol 1990; 7(4):291-301GE

Abstract

Family histories of male patients with histologically confirmed malignant gliomas were compared to family histories of controls (wives). Included were 77 case families with 892 relatives and 77 control families with 719 relatives. Cases had significantly more siblings than controls (P = 0.02), although cases were not preferentially the oldest or the youngest sibs. Odds ratios of two or more were found for mental retardation, Parkinson's disease, and meningitis for the relatives of cases versus controls, but none were statistically significant. The excesses of Parkinson's disease and meningitis were explained by the family of one particularly interesting case containing three relatives with meningitis and two relatives with Parkinson's disease. Noteworthy age-adjusted odds ratios for cancer among relatives of cases compared to relatives of controls were 1.6 (95% confidence interval (CI) = 1.0-2.3) for cancer of any site, 2.4 (95% CI = 0.8-6.1) for breast cancer, and 4.0 (95% CI = 0.6-10.7) for lung cancer. Only the odds ratio for cancer of any site was statistically significant. Overall, 6 of 77 (8%) of cases came from families that included two or more relatives with breast or lung cancer in addition to the proband with malignant glioma. These three cancer sites may form familial clusters worthy of further evaluation in future studies by pedigree and genetic linkage analyses.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco 94143-0560.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2227374

Citation

Wrensch, M R., and G R. Barger. "Familial Factors Associated With Malignant Gliomas." Genetic Epidemiology, vol. 7, no. 4, 1990, pp. 291-301.
Wrensch MR, Barger GR. Familial factors associated with malignant gliomas. Genet Epidemiol. 1990;7(4):291-301.
Wrensch, M. R., & Barger, G. R. (1990). Familial factors associated with malignant gliomas. Genetic Epidemiology, 7(4), pp. 291-301.
Wrensch MR, Barger GR. Familial Factors Associated With Malignant Gliomas. Genet Epidemiol. 1990;7(4):291-301. PubMed PMID: 2227374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial factors associated with malignant gliomas. AU - Wrensch,M R, AU - Barger,G R, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 291 EP - 301 JF - Genetic epidemiology JO - Genet. Epidemiol. VL - 7 IS - 4 N2 - Family histories of male patients with histologically confirmed malignant gliomas were compared to family histories of controls (wives). Included were 77 case families with 892 relatives and 77 control families with 719 relatives. Cases had significantly more siblings than controls (P = 0.02), although cases were not preferentially the oldest or the youngest sibs. Odds ratios of two or more were found for mental retardation, Parkinson's disease, and meningitis for the relatives of cases versus controls, but none were statistically significant. The excesses of Parkinson's disease and meningitis were explained by the family of one particularly interesting case containing three relatives with meningitis and two relatives with Parkinson's disease. Noteworthy age-adjusted odds ratios for cancer among relatives of cases compared to relatives of controls were 1.6 (95% confidence interval (CI) = 1.0-2.3) for cancer of any site, 2.4 (95% CI = 0.8-6.1) for breast cancer, and 4.0 (95% CI = 0.6-10.7) for lung cancer. Only the odds ratio for cancer of any site was statistically significant. Overall, 6 of 77 (8%) of cases came from families that included two or more relatives with breast or lung cancer in addition to the proband with malignant glioma. These three cancer sites may form familial clusters worthy of further evaluation in future studies by pedigree and genetic linkage analyses. SN - 0741-0395 UR - https://www.unboundmedicine.com/medline/citation/2227374/Familial_factors_associated_with_malignant_gliomas_ L2 - https://doi.org/10.1002/gepi.1370070407 DB - PRIME DP - Unbound Medicine ER -