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Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination with ω-6/9 lipid emulsions.
JPEN J Parenter Enteral Nutr 2012; 36(5):587-95JJ

Abstract

BACKGROUND

Newborn infants with short bowel syndrome (SBS) represent a high-risk group of developing intestinal failure-associated liver disease (IFALD), which may be fatal. However, infants have a great capacity for intestinal growth and adaptation if IFALD can be prevented or reversed. A major contributing factor to IFALD may be the soybean oil-based intravenous lipid emulsions used since the introduction of parenteral nutrition (PN) 40 years ago.

METHODS

This retrospective study compares the outcome in 20 neonates with SBS treated with parenteral fish oil (Omegaven) in combination with ω-6/9 lipid emulsions (ClinOleic) with the outcome in a historical cohort of 18 patients with SBS who received a soybean oil-based intravenous lipid emulsion (Intralipid).

RESULTS

Median gestational age was 26 weeks in the treatment group and 35.5 weeks in the historical group. All patients were started on PN containing Intralipid that was switched to ClinOleic/Omegaven in the treatment group at a median age of 39 gestational weeks. In the treatment group, direct bilirubin levels were reversed in all 14 survivors with cholestasis (direct bilirubin >50 umol/L). Median time to reversal was 2.9 months. Only 2 patients died of liver failure (10%). In the historical cohort, 6 patients (33%) died of liver failure, and only 2 patients showed normalization of bilirubin levels.

CONCLUSIONS

Parenteral fish oil in combination with ω-6/9 lipid emulsions was associated with improved outcome in premature neonates with SBS. When used instead of traditional soybean-based emulsions, this mixed lipid emulsion may facilitate intestinal adaptation by increasing the IFALD-free period.

Authors+Show Affiliations

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22275330

Citation

Angsten, Gertrud, et al. "Improved Outcome in Neonatal Short Bowel Syndrome Using Parenteral Fish Oil in Combination With Ω-6/9 Lipid Emulsions." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 36, no. 5, 2012, pp. 587-95.
Angsten G, Finkel Y, Lucas S, et al. Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination with ω-6/9 lipid emulsions. JPEN J Parenter Enteral Nutr. 2012;36(5):587-95.
Angsten, G., Finkel, Y., Lucas, S., Kassa, A. M., Paulsson, M., & Lilja, H. E. (2012). Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination with ω-6/9 lipid emulsions. JPEN. Journal of Parenteral and Enteral Nutrition, 36(5), pp. 587-95. doi:10.1177/0148607111430507.
Angsten G, et al. Improved Outcome in Neonatal Short Bowel Syndrome Using Parenteral Fish Oil in Combination With Ω-6/9 Lipid Emulsions. JPEN J Parenter Enteral Nutr. 2012;36(5):587-95. PubMed PMID: 22275330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination with ω-6/9 lipid emulsions. AU - Angsten,Gertrud, AU - Finkel,Yigael, AU - Lucas,Steven, AU - Kassa,Ann-Marie, AU - Paulsson,Mattias, AU - Lilja,Helene Engstrand, Y1 - 2012/01/24/ PY - 2012/1/26/entrez PY - 2012/1/26/pubmed PY - 2013/1/4/medline SP - 587 EP - 95 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 36 IS - 5 N2 - BACKGROUND: Newborn infants with short bowel syndrome (SBS) represent a high-risk group of developing intestinal failure-associated liver disease (IFALD), which may be fatal. However, infants have a great capacity for intestinal growth and adaptation if IFALD can be prevented or reversed. A major contributing factor to IFALD may be the soybean oil-based intravenous lipid emulsions used since the introduction of parenteral nutrition (PN) 40 years ago. METHODS: This retrospective study compares the outcome in 20 neonates with SBS treated with parenteral fish oil (Omegaven) in combination with ω-6/9 lipid emulsions (ClinOleic) with the outcome in a historical cohort of 18 patients with SBS who received a soybean oil-based intravenous lipid emulsion (Intralipid). RESULTS: Median gestational age was 26 weeks in the treatment group and 35.5 weeks in the historical group. All patients were started on PN containing Intralipid that was switched to ClinOleic/Omegaven in the treatment group at a median age of 39 gestational weeks. In the treatment group, direct bilirubin levels were reversed in all 14 survivors with cholestasis (direct bilirubin >50 umol/L). Median time to reversal was 2.9 months. Only 2 patients died of liver failure (10%). In the historical cohort, 6 patients (33%) died of liver failure, and only 2 patients showed normalization of bilirubin levels. CONCLUSIONS: Parenteral fish oil in combination with ω-6/9 lipid emulsions was associated with improved outcome in premature neonates with SBS. When used instead of traditional soybean-based emulsions, this mixed lipid emulsion may facilitate intestinal adaptation by increasing the IFALD-free period. SN - 1941-2444 UR - https://www.unboundmedicine.com/medline/citation/22275330/Improved_outcome_in_neonatal_short_bowel_syndrome_using_parenteral_fish_oil_in_combination_with_ω_6/9_lipid_emulsions_ L2 - https://doi.org/10.1177/0148607111430507 DB - PRIME DP - Unbound Medicine ER -