Tags

Type your tag names separated by a space and hit enter

Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies.
Am J Clin Nutr. 2012 Mar; 95(3):713-25.AJ

Abstract

BACKGROUND

Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited.

OBJECTIVE

We investigated these associations in a pooled analysis of 18 cohort studies.

DESIGN

Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model.

RESULTS

α-Carotene, β-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): α-carotene (0.87; 95% CI: 0.78, 0.97), β-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): α-carotene (1.04; 95% CI: 0.99, 1.09), β-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for β-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend ≤ 0.05). Nonsignificant associations were observed for lycopene intake. The associations were largely not appreciably modified by several breast cancer risk factors. Nonsignificant associations were observed for PR-positive and PR-negative breast cancer.

CONCLUSIONS

Intakes of α-carotene, β-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, but not ER+, breast cancer. However, the results need to be interpreted with caution because it is unclear whether the observed association is real or due to other constituents in the same food sources.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. pooling@hsphsun2.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22277553

Citation

Zhang, Xuehong, et al. "Carotenoid Intakes and Risk of Breast Cancer Defined By Estrogen Receptor and Progesterone Receptor Status: a Pooled Analysis of 18 Prospective Cohort Studies." The American Journal of Clinical Nutrition, vol. 95, no. 3, 2012, pp. 713-25.
Zhang X, Spiegelman D, Baglietto L, et al. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. Am J Clin Nutr. 2012;95(3):713-25.
Zhang, X., Spiegelman, D., Baglietto, L., Bernstein, L., Boggs, D. A., van den Brandt, P. A., Buring, J. E., Gapstur, S. M., Giles, G. G., Giovannucci, E., Goodman, G., Hankinson, S. E., Helzlsouer, K. J., Horn-Ross, P. L., Inoue, M., Jung, S., Khudyakov, P., Larsson, S. C., Lof, M., ... Smith-Warner, S. A. (2012). Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. The American Journal of Clinical Nutrition, 95(3), 713-25. https://doi.org/10.3945/ajcn.111.014415
Zhang X, et al. Carotenoid Intakes and Risk of Breast Cancer Defined By Estrogen Receptor and Progesterone Receptor Status: a Pooled Analysis of 18 Prospective Cohort Studies. Am J Clin Nutr. 2012;95(3):713-25. PubMed PMID: 22277553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. AU - Zhang,Xuehong, AU - Spiegelman,Donna, AU - Baglietto,Laura, AU - Bernstein,Leslie, AU - Boggs,Deborah A, AU - van den Brandt,Piet A, AU - Buring,Julie E, AU - Gapstur,Susan M, AU - Giles,Graham G, AU - Giovannucci,Edward, AU - Goodman,Gary, AU - Hankinson,Susan E, AU - Helzlsouer,Kathy J, AU - Horn-Ross,Pamela L, AU - Inoue,Manami, AU - Jung,Seungyoun, AU - Khudyakov,Polyna, AU - Larsson,Susanna C, AU - Lof,Marie, AU - McCullough,Marjorie L, AU - Miller,Anthony B, AU - Neuhouser,Marian L, AU - Palmer,Julie R, AU - Park,Yikyung, AU - Robien,Kim, AU - Rohan,Thomas E, AU - Ross,Julie A, AU - Schouten,Leo J, AU - Shikany,James M, AU - Tsugane,Shoichiro, AU - Visvanathan,Kala, AU - Weiderpass,Elisabete, AU - Wolk,Alicja, AU - Willett,Walter C, AU - Zhang,Shumin M, AU - Ziegler,Regina G, AU - Smith-Warner,Stephanie A, Y1 - 2012/01/25/ PY - 2012/1/27/entrez PY - 2012/1/27/pubmed PY - 2012/4/10/medline SP - 713 EP - 25 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 3 N2 - BACKGROUND: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. OBJECTIVE: We investigated these associations in a pooled analysis of 18 cohort studies. DESIGN: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. RESULTS: α-Carotene, β-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): α-carotene (0.87; 95% CI: 0.78, 0.97), β-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): α-carotene (1.04; 95% CI: 0.99, 1.09), β-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for β-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend ≤ 0.05). Nonsignificant associations were observed for lycopene intake. The associations were largely not appreciably modified by several breast cancer risk factors. Nonsignificant associations were observed for PR-positive and PR-negative breast cancer. CONCLUSIONS: Intakes of α-carotene, β-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, but not ER+, breast cancer. However, the results need to be interpreted with caution because it is unclear whether the observed association is real or due to other constituents in the same food sources. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22277553/Carotenoid_intakes_and_risk_of_breast_cancer_defined_by_estrogen_receptor_and_progesterone_receptor_status:_a_pooled_analysis_of_18_prospective_cohort_studies_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.014415 DB - PRIME DP - Unbound Medicine ER -