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Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies.

Abstract

BACKGROUND

Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited.

OBJECTIVE

We investigated these associations in a pooled analysis of 18 cohort studies.

DESIGN

Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model.

RESULTS

α-Carotene, β-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): α-carotene (0.87; 95% CI: 0.78, 0.97), β-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): α-carotene (1.04; 95% CI: 0.99, 1.09), β-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for β-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend ≤ 0.05). Nonsignificant associations were observed for lycopene intake. The associations were largely not appreciably modified by several breast cancer risk factors. Nonsignificant associations were observed for PR-positive and PR-negative breast cancer.

CONCLUSIONS

Intakes of α-carotene, β-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, but not ER+, breast cancer. However, the results need to be interpreted with caution because it is unclear whether the observed association is real or due to other constituents in the same food sources.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. pooling@hsphsun2.harvard.edu

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Breast Neoplasms
    Carotenoids
    Female
    Follow-Up Studies
    Humans
    Lutein
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Surveys and Questionnaires
    Xanthophylls
    Young Adult
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22277553

    Citation

    Zhang, Xuehong, et al. "Carotenoid Intakes and Risk of Breast Cancer Defined By Estrogen Receptor and Progesterone Receptor Status: a Pooled Analysis of 18 Prospective Cohort Studies." The American Journal of Clinical Nutrition, vol. 95, no. 3, 2012, pp. 713-25.
    Zhang X, Spiegelman D, Baglietto L, et al. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. Am J Clin Nutr. 2012;95(3):713-25.
    Zhang, X., Spiegelman, D., Baglietto, L., Bernstein, L., Boggs, D. A., van den Brandt, P. A., ... Smith-Warner, S. A. (2012). Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. The American Journal of Clinical Nutrition, 95(3), pp. 713-25. doi:10.3945/ajcn.111.014415.
    Zhang X, et al. Carotenoid Intakes and Risk of Breast Cancer Defined By Estrogen Receptor and Progesterone Receptor Status: a Pooled Analysis of 18 Prospective Cohort Studies. Am J Clin Nutr. 2012;95(3):713-25. PubMed PMID: 22277553.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. AU - Zhang,Xuehong, AU - Spiegelman,Donna, AU - Baglietto,Laura, AU - Bernstein,Leslie, AU - Boggs,Deborah A, AU - van den Brandt,Piet A, AU - Buring,Julie E, AU - Gapstur,Susan M, AU - Giles,Graham G, AU - Giovannucci,Edward, AU - Goodman,Gary, AU - Hankinson,Susan E, AU - Helzlsouer,Kathy J, AU - Horn-Ross,Pamela L, AU - Inoue,Manami, AU - Jung,Seungyoun, AU - Khudyakov,Polyna, AU - Larsson,Susanna C, AU - Lof,Marie, AU - McCullough,Marjorie L, AU - Miller,Anthony B, AU - Neuhouser,Marian L, AU - Palmer,Julie R, AU - Park,Yikyung, AU - Robien,Kim, AU - Rohan,Thomas E, AU - Ross,Julie A, AU - Schouten,Leo J, AU - Shikany,James M, AU - Tsugane,Shoichiro, AU - Visvanathan,Kala, AU - Weiderpass,Elisabete, AU - Wolk,Alicja, AU - Willett,Walter C, AU - Zhang,Shumin M, AU - Ziegler,Regina G, AU - Smith-Warner,Stephanie A, Y1 - 2012/01/25/ PY - 2012/1/27/entrez PY - 2012/1/27/pubmed PY - 2012/4/10/medline SP - 713 EP - 25 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 3 N2 - BACKGROUND: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. OBJECTIVE: We investigated these associations in a pooled analysis of 18 cohort studies. DESIGN: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. RESULTS: α-Carotene, β-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): α-carotene (0.87; 95% CI: 0.78, 0.97), β-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): α-carotene (1.04; 95% CI: 0.99, 1.09), β-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for β-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend ≤ 0.05). Nonsignificant associations were observed for lycopene intake. The associations were largely not appreciably modified by several breast cancer risk factors. Nonsignificant associations were observed for PR-positive and PR-negative breast cancer. CONCLUSIONS: Intakes of α-carotene, β-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, but not ER+, breast cancer. However, the results need to be interpreted with caution because it is unclear whether the observed association is real or due to other constituents in the same food sources. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22277553/Carotenoid_intakes_and_risk_of_breast_cancer_defined_by_estrogen_receptor_and_progesterone_receptor_status:_a_pooled_analysis_of_18_prospective_cohort_studies_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.014415 DB - PRIME DP - Unbound Medicine ER -